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Durable left ventricular assist devices following temporary circulatory support on a microaxial flow pump with and without extracorporeal life support
D. Lewin, SV. Rojas, M. Billion, AL. Meyer, I. Netuka, J. Kooij, M. Pieri, A. Loforte, MK. Szymanski, CH. Moeller, P. Akhyari, K. Jawad, I. Krasivskyi, B. Schmack, G. Färber, M. Medina, A. Haneya, D. Zimpfer, G. Nersesian, M. Oezkur, I....
Status neindexováno Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2020
PubMed Central
od 2020
ROAD: Directory of Open Access Scholarly Resources
od 2020
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Circulatory support with a catheter-based microaxial flow pump (mAFP) plays a major role in the treatment of severe cardiogenic shock. In most patients who fail to recover while on temporary mechanical circulatory support (tMCS) and who are not eligible for heart transplantation, durable left ventricular assist device (dLVAD) implantation is usually considered a reliable option. This study aimed to describe the outcome of dLVAD therapy following mAFP support and to identify predictors of mortality. METHODS: This was a retrospective analysis of data from a multicenter registry on patients who underwent dLVAD implantation following tMCS with a mAFP between January 2017 and October 2022 (n = 332) from 19 European centers. RESULTS: Patients were supported with an Impella 5.5 (n = 92), 5.0 (n = 153) or CP (n = 87) and were transitioned to a HeartWare HVAD (n = 128) or Heartmate 3 (n = 204) during the same period. One hundred and twenty-five patients (39.2%) also required extracorporeal life support before and/or during mAFP therapy. The 30-day and 1-year survival were 87.8% and 71.1%, respectively. The following risk factors for 1-year mortality were identified: age (odds ratio [OR], 1.02), specifically age over 55 years (OR, 1.09), body mass index >30 kg/m2 (OR, 2.2), female sex (OR for male sex, 0.43), elevated total bilirubin (OR, 1.12), and low platelet count (OR, 0.996). CONCLUSIONS: Based on the identified risk factors, a risk score for estimating 1-year mortality was calculated to optimize patient selection for dLVAD implantation.
Department of Anesthesia and Intensive Care IRCCS San Raffaele Scientific Institute Milan Italy
Department of Cardiac and Vascular Surgery University of Mainz Mainz Germany
Department of Cardiac Surgery Heidelberg University Hospital Heidelberg Germany
Department of Cardiac Surgery Leipzig Heart Center Leipzig Germany
Department of Cardiac Surgery Schüchtermann Clinic Bad Rothenfelde Germany
Department of Cardiac Surgery University Hospitals Leuven Leuven Belgium
Department of Cardiac Surgery University of Essen Essen Germany
Department of Cardiology University Medical Center Utrecht Utrecht The Netherlands
Department of Cardiothoracic and Vascular Surgery Deutsches Herzzentrum der Charité Berlin Germany
Department of Cardiothoracic Surgery Jena University Hospital Jena Germany
Department of Cardiothoracic Surgery Rigshospitalet Copenhagen Denmark
Department of Cardiothoracic Surgery University Hospital Cologne Cologne Germany
Department of Cardiothoracic Surgery University Hospital RTWH Aachen Aachen Germany
Department of Cardiovascular Surgery Charité Universitätsmedizin Berlin Berlin Germany
Department of Cardiovascular Surgery University Heart Center Hamburg Hamburg Germany
Department of Cardiovascular Surgery University Hospital Duesseldorf Duesseldorf Germany
Department of Cardiovascular Surgery University Hospital Schleswig Holstein Kiel Germany
Department of Surgical Sciences University of Turin Turin Italy
Division of Cardiac Surgery Department of Surgery Medical University of Vienna Vienna Austria
German Center for Cardiovascular Research Berlin Germany
Heart and Diabetes Center Bad Oeynhausen North Rhine Westphalia Germany
Institute of Clinical and Experimental Medicine Prague Czech Republic
Citace poskytuje Crossref.org
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- $a Durable left ventricular assist devices following temporary circulatory support on a microaxial flow pump with and without extracorporeal life support / $c D. Lewin, SV. Rojas, M. Billion, AL. Meyer, I. Netuka, J. Kooij, M. Pieri, A. Loforte, MK. Szymanski, CH. Moeller, P. Akhyari, K. Jawad, I. Krasivskyi, B. Schmack, G. Färber, M. Medina, A. Haneya, D. Zimpfer, G. Nersesian, M. Oezkur, I. Djordjevic, D. Saeed, J. Stein, AO. Kraaijeveld, F. Gustafsson, M. Scandroglio, B. Meyns, S. Hofmann, J. Belohlavek, JF. Gummert, P. Lanmueller, AM. Bernhardt, EV. Potapov
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- $a BACKGROUND: Circulatory support with a catheter-based microaxial flow pump (mAFP) plays a major role in the treatment of severe cardiogenic shock. In most patients who fail to recover while on temporary mechanical circulatory support (tMCS) and who are not eligible for heart transplantation, durable left ventricular assist device (dLVAD) implantation is usually considered a reliable option. This study aimed to describe the outcome of dLVAD therapy following mAFP support and to identify predictors of mortality. METHODS: This was a retrospective analysis of data from a multicenter registry on patients who underwent dLVAD implantation following tMCS with a mAFP between January 2017 and October 2022 (n = 332) from 19 European centers. RESULTS: Patients were supported with an Impella 5.5 (n = 92), 5.0 (n = 153) or CP (n = 87) and were transitioned to a HeartWare HVAD (n = 128) or Heartmate 3 (n = 204) during the same period. One hundred and twenty-five patients (39.2%) also required extracorporeal life support before and/or during mAFP therapy. The 30-day and 1-year survival were 87.8% and 71.1%, respectively. The following risk factors for 1-year mortality were identified: age (odds ratio [OR], 1.02), specifically age over 55 years (OR, 1.09), body mass index >30 kg/m2 (OR, 2.2), female sex (OR for male sex, 0.43), elevated total bilirubin (OR, 1.12), and low platelet count (OR, 0.996). CONCLUSIONS: Based on the identified risk factors, a risk score for estimating 1-year mortality was calculated to optimize patient selection for dLVAD implantation.
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