• Je něco špatně v tomto záznamu ?

Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence

H. Wang, Q. You, B. Kang, H. Jing, Z. Shi, S. Krizkova, Z. Heger, V. Adam, X. Chen, N. Li

. 2024 ; 36 (49) : e2406590. [pub] 20241015

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25003217

Grantová podpora
0701320001 Young Elite Scientists Sponsorship Program by Tianjin
0402080005 Major Special Projects
2020YFC1512304 National Key R&D Program of China
NUHSRO/2020/133/Startup/08 National University of Singapore
NUHSRO/2023/008/NUSMed/TCE/LOA National University of Singapore
NUHSRO/2021/034/TRP/09/Nanomedicine National University of Singapore
MOH-001388-00 National Medical Research Council
MOH-001041 National Medical Research Council
CG21APR1005 National Medical Research Council
NRF-000352-00 National Research Foundation
23-04740 M Czech Science Foundation
82273873 National Natural Science Foundation of China
31971106 National Natural Science Foundation of China
81372124 National Natural Science Foundation of China
MOE-000387-00 Singapore Ministry of Education

Hepatic fibrosis progresses concomitantly with a variety of biomechanical alternations, especially increased liver stiffness. These biomechanical alterations have long been considered as pathological consequences. Recently, growing evidence proposes that these alternations result in the fibrotic biomechanical microenvironment, which drives the activation of hepatic stellate cells (HSCs). Here, an inorganic ascorbic acid-oxidase (AAO) mimicking nanozyme loaded with liquiritigenin (LQ) is developed to trigger remodeling of the fibrotic biomechanical microenvironment. The AAO mimicking nanozyme is able to consume intracellular ascorbic acid, thereby impeding collagen I deposition by reducing its availability. Simultaneously, LQ inhibits the transcription of lysyl oxidase like 2 (LOXL2), thus impeding collagen I crosslinking. Through its synergistic activities, the prepared nanosystem efficiently restores the fibrotic biomechanical microenvironment to a near-normal physiological condition, promoting the quiescence of HSCs and regression of fibrosis. This strategy of remodeling the fibrotic biomechanical microenvironment, akin to "pulling the rug out from under", effectively treats hepatic fibrosis in mice, thereby highlighting the importance of tissue biomechanics and providing a potential approach to improve hepatic fibrosis treatment.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003217
003      
CZ-PrNML
005      
20250206104156.0
007      
ta
008      
250121s2024 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1002/adma.202406590 $2 doi
035    __
$a (PubMed)39410721
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Wang, Haobo $u Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
245    10
$a Pulling the Rug Out from Under: Biomechanical Microenvironment Remodeling for Induction of Hepatic Stellate Cell Quiescence / $c H. Wang, Q. You, B. Kang, H. Jing, Z. Shi, S. Krizkova, Z. Heger, V. Adam, X. Chen, N. Li
520    9_
$a Hepatic fibrosis progresses concomitantly with a variety of biomechanical alternations, especially increased liver stiffness. These biomechanical alterations have long been considered as pathological consequences. Recently, growing evidence proposes that these alternations result in the fibrotic biomechanical microenvironment, which drives the activation of hepatic stellate cells (HSCs). Here, an inorganic ascorbic acid-oxidase (AAO) mimicking nanozyme loaded with liquiritigenin (LQ) is developed to trigger remodeling of the fibrotic biomechanical microenvironment. The AAO mimicking nanozyme is able to consume intracellular ascorbic acid, thereby impeding collagen I deposition by reducing its availability. Simultaneously, LQ inhibits the transcription of lysyl oxidase like 2 (LOXL2), thus impeding collagen I crosslinking. Through its synergistic activities, the prepared nanosystem efficiently restores the fibrotic biomechanical microenvironment to a near-normal physiological condition, promoting the quiescence of HSCs and regression of fibrosis. This strategy of remodeling the fibrotic biomechanical microenvironment, akin to "pulling the rug out from under", effectively treats hepatic fibrosis in mice, thereby highlighting the importance of tissue biomechanics and providing a potential approach to improve hepatic fibrosis treatment.
650    12
$a jaterní hvězdicovité buňky $x metabolismus $x cytologie $x účinky léků $7 D055166
650    _2
$a zvířata $7 D000818
650    _2
$a myši $7 D051379
650    12
$a jaterní cirhóza $x farmakoterapie $x metabolismus $x patologie $7 D008103
650    12
$a kyselina askorbová $x farmakologie $x metabolismus $x chemie $7 D001205
650    _2
$a biomechanika $7 D001696
650    _2
$a buněčné mikroprostředí $x účinky léků $7 D060833
650    _2
$a flavanony $x farmakologie $x chemie $7 D044950
650    _2
$a lidé $7 D006801
650    _2
$a kolagen typu I $x metabolismus $7 D024042
655    _2
$a časopisecké články $7 D016428
700    1_
$a You, Qing $u Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119074, Singapore $u Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore
700    1_
$a Kang, Bei $u Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
700    1_
$a Jing, Huaqing $u Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
700    1_
$a Shi, Zhiyuan $u Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
700    1_
$a Krizkova, Sona $u Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, CZ-61300, Czech Republic
700    1_
$a Heger, Zbynek $u Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, CZ-61300, Czech Republic $u Center of Advanced Innovation Technologies, Faculty of Materials Science and Technology, VSB - Technical University of Ostrava, Ostrava, CZ-708 00, Czech Republic $1 https://orcid.org/0000000239157270 $7 xx0276759
700    1_
$a Adam, Vojtech $u Department of Chemistry and Biochemistry, Mendel University in Brno, Brno, CZ-61300, Czech Republic
700    1_
$a Chen, Xiaoyuan $u Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore, 119074, Singapore $u Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117599, Singapore $u Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore $u Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore, 138673, Singapore $1 https://orcid.org/0000000296220870 $7 xx0166544
700    1_
$a Li, Nan $u Tianjin Key Laboratory of Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, 300072, China
773    0_
$w MED00006520 $t Advanced materials $x 1521-4095 $g Roč. 36, č. 49 (2024), s. e2406590
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39410721 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104151 $b ABA008
999    __
$a ok $b bmc $g 2263145 $s 1239224
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 36 $c 49 $d e2406590 $e 20241015 $i 1521-4095 $m Advanced materials $n Adv Mater $x MED00006520
GRA    __
$a 0701320001 $p Young Elite Scientists Sponsorship Program by Tianjin
GRA    __
$a 0402080005 $p Major Special Projects
GRA    __
$a 2020YFC1512304 $p National Key R&D Program of China
GRA    __
$a NUHSRO/2020/133/Startup/08 $p National University of Singapore
GRA    __
$a NUHSRO/2023/008/NUSMed/TCE/LOA $p National University of Singapore
GRA    __
$a NUHSRO/2021/034/TRP/09/Nanomedicine $p National University of Singapore
GRA    __
$a MOH-001388-00 $p National Medical Research Council
GRA    __
$a MOH-001041 $p National Medical Research Council
GRA    __
$a CG21APR1005 $p National Medical Research Council
GRA    __
$a NRF-000352-00 $p National Research Foundation
GRA    __
$a 23-04740 M $p Czech Science Foundation
GRA    __
$a 82273873 $p National Natural Science Foundation of China
GRA    __
$a 31971106 $p National Natural Science Foundation of China
GRA    __
$a 81372124 $p National Natural Science Foundation of China
GRA    __
$a MOE-000387-00 $p Singapore Ministry of Education
LZP    __
$a Pubmed-20250121

Najít záznam

Citační ukazatele

Možnosti archivace