-
Something wrong with this record ?
Metabolomics and proteomics in pheochromocytoma and paraganglioma: Translating biochemistry and biology to bedside
J. Petrak, SG. Tevosian, S. Richter, HK. Ghayee
Language English Country Netherlands
Document type Journal Article
- MeSH
- Pheochromocytoma * metabolism diagnosis MeSH
- Humans MeSH
- Metabolomics * methods MeSH
- Adrenal Gland Neoplasms * metabolism diagnosis MeSH
- Paraganglioma * metabolism diagnosis MeSH
- Proteomics * methods MeSH
- Translational Research, Biomedical MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
The complexity of omes - the key cellular ensembles (genome and epigenome, transcriptome, proteome, and metabolome) - is becoming increasingly understood in terms of big-data analysis, the omics. Amongst these, proteomics provides a global description of quantitative and qualitative alterations of protein expression (or protein abundance in body fluids) in response to physiologic or pathologic processes while metabolomics offers a functional portrait of the physiological state by quantifying metabolite abundances in biological samples. Here, we summarize how different techniques of proteomic and metabolic analysis can be used to define key biochemical characteristics of pheochromocytomas/paragangliomas (PPGL). The significance of omics in understanding features of PPGL biology that might translate to improved diagnosis and treatment will be highlighted.
BIOCEV 1st Faculty of Medicine Charles University Vestec Czech Republic
Department of Physiological Sciences University of Florida Gainesville FL USA
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25003260
- 003
- CZ-PrNML
- 005
- 20250206104216.0
- 007
- ta
- 008
- 250121s2024 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.beem.2024.101935 $2 doi
- 035 __
- $a (PubMed)39299859
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Petrak, Jiri $u BIOCEV, First Faculty of Medicine, Charles University, Vestec, Czech Republic. Electronic address: jpetr@lf1.cuni.cz
- 245 10
- $a Metabolomics and proteomics in pheochromocytoma and paraganglioma: Translating biochemistry and biology to bedside / $c J. Petrak, SG. Tevosian, S. Richter, HK. Ghayee
- 520 9_
- $a The complexity of omes - the key cellular ensembles (genome and epigenome, transcriptome, proteome, and metabolome) - is becoming increasingly understood in terms of big-data analysis, the omics. Amongst these, proteomics provides a global description of quantitative and qualitative alterations of protein expression (or protein abundance in body fluids) in response to physiologic or pathologic processes while metabolomics offers a functional portrait of the physiological state by quantifying metabolite abundances in biological samples. Here, we summarize how different techniques of proteomic and metabolic analysis can be used to define key biochemical characteristics of pheochromocytomas/paragangliomas (PPGL). The significance of omics in understanding features of PPGL biology that might translate to improved diagnosis and treatment will be highlighted.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a nádory nadledvin $x metabolismus $x diagnóza $7 D000310
- 650 12
- $a metabolomika $x metody $7 D055432
- 650 12
- $a paragangliom $x metabolismus $x diagnóza $7 D010235
- 650 12
- $a feochromocytom $x metabolismus $x diagnóza $7 D010673
- 650 12
- $a proteomika $x metody $7 D040901
- 650 _2
- $a translační biomedicínský výzkum $7 D057170
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Tevosian, Sergei G $u Department of Physiological Sciences, University of Florida, Gainesville, FL, USA
- 700 1_
- $a Richter, Susan $u Institute of Clinical Chemistry and Laboratory Medicine, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
- 700 1_
- $a Ghayee, Hans K $u Department of Medicine, Division of Endocrinology & Metabolism, Malcom Randall VA Medical Center, University of Florida, Gainesville, FL, USA. Electronic address: hans.ghayee@medicine.ufl.edu
- 773 0_
- $w MED00013220 $t Baillière's best practice & research. Clinical endocrinology & metabolism $x 1878-1594 $g Roč. 38, č. 6 (2024), s. 101935
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39299859 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250121 $b ABA008
- 991 __
- $a 20250206104212 $b ABA008
- 999 __
- $a ok $b bmc $g 2263173 $s 1239267
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 38 $c 6 $d 101935 $e 20240905 $i 1878-1594 $m Baillière's best practice & research. Clinical endocrinology & metabolism $n Best Pract Res Clin Endocrinol Metab $x MED00013220
- LZP __
- $a Pubmed-20250121
