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Enhancing therapeutic reasoning: key insights and recommendations for education in prescribing

MG. Hartjes, MC. Richir, Y. Cazaubon, EM. Donker, E. van Leeuwen, R. Likic, YM. Pers, JD. Piët, F. De Ponti, W. Raasch, F. van Rosse, J. Rychlícková, EJ. Sanz, M. Schwaninger, SM. Wallerstedt, TPGM. de Vries, MA. van Agtmael, J. Tichelaar, EACPT...

. 2024 ; 24 (1) : 1360. [pub] 20241126

Language English Country England, Great Britain

Document type Journal Article, Review

BACKGROUND: Despite efforts to improve undergraduate clinical pharmacology & therapeutics (CPT) education, prescribing errors are still made regularly. To improve CPT education and daily prescribing, it is crucial to understand how therapeutic reasoning works. Therefore, the aim of this study was to gain insight into the therapeutic reasoning process. METHODS: A narrative literature review has been performed for literature on cognitive psychology and diagnostic and therapeutic reasoning. RESULTS: Based on these insights, The European Model of Therapeutic Reasoning has been developed, building upon earlier models and insights from cognitive psychology. In this model, it can be assumed that when a diagnosis is made, a primary, automatic response as to what to prescribe arises based on pattern recognition via therapy scripts (type 1 thinking). At some point, this response may be evaluated by the reflective mind (using metacognition). If it is found to be incorrect or incomplete, an alternative response must be formulated through a slower, more analytical and deliberative process, known as type 2 thinking. Metacognition monitors the reasoning process and helps a person to form new therapy scripts after they have chosen an effective therapy. Experienced physicians have more and richer therapy scripts, mostly based on experience and enabling conditions, instead of textbook knowledge, and therefore their type 1 response is more often correct. CONCLUSION: Because of the important role of metacognition in therapeutic reasoning, more attention should be paid to metacognition in CPT education. Both trainees and teachers should be aware of the possibility to monitor and influence these cognitive processes. Further research is required to investigate the applicability of these insights and the adaptability of educational approaches to therapeutic reasoning.

Clinical Immunology and Osteoarticular Diseases Therapeutic Unit Lapeyronie University Hospital Montpellier France

Department of Fundamental and Applied Medical Sciences Unit of Clinical Pharmacology Ghent University C Heymanslaan 10 9000 Ghent Belgium

Department of Hospital Pharmacy University Medical Center Rotterdam MC Rotterdam The Netherlands

Department of Internal Medicine Unit Pharmacotherapy Amsterdam UMC Vrije Universiteit De Boelelaan 1117 1081 HV Amsterdam The Netherlands

Department of Medical and Surgical Sciences Pharmacology Unit Alma Mater Studiorum University of Bologna Via Zamboni 33 40126 Bologna Italy

Department of Pharmacology Faculty of Medicine Masaryk University Brno Czech Republic

Department of Pharmacology Montpellier University Hospital Avenue du Doyen Gaston Giraud 34090 Montpellier France

Department of Pharmacology Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

Department of Surgery University Medical Center Utrecht Heidelberglaan 100 3584 CX Utrecht The Netherlands

Institute of Experimental and Clinical Pharmacology and Toxicology University of Lübeck Lübeck Germany

Interprofessional Collaboration and Medication Safety Faculty of Health Sports and Social Work InHolland University of Applied Sciences Pina Bauschplein 4 1095PN Amsterdam The Netherlands

IRMB University Montpellier INSERM CHU Montpellier Montpellier France

Pathogenesis and Control of Chronic and Emerging Infections INSERM University Montpellier 34090 Montpellier France

Research and Expertise Centre in Pharmacotherapy Education De Boelelaan 1117 1081 HV Amsterdam The Netherlands

School of Health Science Universidad de La Laguna and Hospital Universitario de Canarias Santa Cruz de Tenerife Calle Padre Herrera S N 38200 La Laguna Tenerife Spain

Unit of Clinical Pharmacology Department of Internal Medicine University Hospital Centre Zagreb and University of Zagreb School of Medicine 12 Kišpatićeva St 10 000 Zagreb Croatia

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