Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Avian Models for Human Carcinogenesis-Recent Findings from Molecular and Clinical Research

J. Niebora, K. Data, D. Domagała, M. Józkowiak, S. Barrett, T. Norizadeh Abbariki, A. Bryja, M. Kulus, S. Woźniak, H. Ziemak, H. Piotrowska-Kempisty, P. Antosik, D. Bukowska, P. Mozdziak, P. Dzięgiel, B. Kempisty

. 2024 ; 13 (21) : . [pub] 20241030

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc25003763

Grant support
NC7082 National Institute of Food and Agriculture

Birds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, as it enabled the discovery of oncogenes. Furthermore, studies on avian viruses provided initial insights into Kaposi's sarcoma and EBV-induced diseases. However, the role of birds in human carcinogenesis extends beyond the realm of virology research. Utilization of CAM, the chorioallantoic membrane, an easily accessible extraembryonic tissue with rich vasculature, has enabled studies on tumor-induced angiogenesis and metastasis and the efficient screening of potential anti-cancer compounds. Also, the chick embryo alone is an effective preclinical in vivo patient-derived xenograft model, which is important for the development of personalized therapies. Furthermore, adult birds may also closely resemble human oncogenesis, as evidenced by the laying hen, which is the only animal model of a spontaneous form of ovarian cancer. Avian models may create an interesting alternative compared with mammalian models, enabling the creation of a relatively cost-effective and easy-to-maintain platform to address key questions in cancer biology.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003763
003      
CZ-PrNML
005      
20250206104702.0
007      
ta
008      
250121s2024 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/cells13211797 $2 doi
035    __
$a (PubMed)39513904
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Niebora, Julia $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland
245    10
$a Avian Models for Human Carcinogenesis-Recent Findings from Molecular and Clinical Research / $c J. Niebora, K. Data, D. Domagała, M. Józkowiak, S. Barrett, T. Norizadeh Abbariki, A. Bryja, M. Kulus, S. Woźniak, H. Ziemak, H. Piotrowska-Kempisty, P. Antosik, D. Bukowska, P. Mozdziak, P. Dzięgiel, B. Kempisty
520    9_
$a Birds, especially the chick and hen, have been important biomedical research models for centuries due to the accessibility of the avian embryo and the early discovery of avian viruses. Comprehension of avian tumor virology was a milestone in basic cancer research, as was that of non-viral genesis, as it enabled the discovery of oncogenes. Furthermore, studies on avian viruses provided initial insights into Kaposi's sarcoma and EBV-induced diseases. However, the role of birds in human carcinogenesis extends beyond the realm of virology research. Utilization of CAM, the chorioallantoic membrane, an easily accessible extraembryonic tissue with rich vasculature, has enabled studies on tumor-induced angiogenesis and metastasis and the efficient screening of potential anti-cancer compounds. Also, the chick embryo alone is an effective preclinical in vivo patient-derived xenograft model, which is important for the development of personalized therapies. Furthermore, adult birds may also closely resemble human oncogenesis, as evidenced by the laying hen, which is the only animal model of a spontaneous form of ovarian cancer. Avian models may create an interesting alternative compared with mammalian models, enabling the creation of a relatively cost-effective and easy-to-maintain platform to address key questions in cancer biology.
650    _2
$a zvířata $7 D000818
650    _2
$a lidé $7 D006801
650    12
$a karcinogeneze $x patologie $x genetika $7 D063646
650    12
$a modely nemocí na zvířatech $7 D004195
650    _2
$a nádory $x patologie $x genetika $7 D009369
650    _2
$a kuřecí embryo $7 D002642
650    _2
$a ptáci $7 D001717
650    _2
$a kur domácí $7 D002645
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Data, Krzysztof $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0000000290185357
700    1_
$a Domagała, Dominika $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0009000852207851
700    1_
$a Józkowiak, Małgorzata $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland $u Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland
700    1_
$a Barrett, Saoirse $u Human Clinical Embryology & Assisted Conception, School of Medicine, University of Dundee, Dundee DD1 4HN, UK
700    1_
$a Norizadeh Abbariki, Tannaz $u Flyblast BV, 2020 Antwerp, Belgium
700    1_
$a Bryja, Artur $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0000000243388119
700    1_
$a Kulus, Magdalena $u Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland $1 https://orcid.org/0000000310985627
700    1_
$a Woźniak, Sławomir $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland $1 https://orcid.org/0000000274507993
700    1_
$a Ziemak, Hanna $u Veterinary Clinic of the Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
700    1_
$a Piotrowska-Kempisty, Hanna $u Department of Toxicology, Poznan University of Medical Sciences, 60-631 Poznan, Poland $u Department of Basic and Preclinical Science, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
700    1_
$a Antosik, Paweł $u Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
700    1_
$a Bukowska, Dorota $u Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland
700    1_
$a Mozdziak, Paul $u Prestage Department of Poultry Science, North Carolina State University, Raleigh, NC 27695, USA $u Physiology Graduate Faculty, North Carolina State University, Raleigh, NC 27695, USA $1 https://orcid.org/0000000215753123
700    1_
$a Dzięgiel, Piotr $u Division of Histology and Embryology, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland
700    1_
$a Kempisty, Bartosz $u Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 50-368 Wroclaw, Poland $u Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland $u Physiology Graduate Faculty, North Carolina State University, Raleigh, NC 27695, USA $u Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, 601 77 Brno, Czech Republic
773    0_
$w MED00194911 $t Cells $x 2073-4409 $g Roč. 13, č. 21 (2024)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39513904 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104657 $b ABA008
999    __
$a ok $b bmc $g 2263505 $s 1239770
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 13 $c 21 $e 20241030 $i 2073-4409 $m Cells $n Cells $x MED00194911
GRA    __
$a NC7082 $p National Institute of Food and Agriculture
LZP    __
$a Pubmed-20250121

Find record

Citation metrics

Archiving options