Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia

CM. Weise, A. Engel, M. Polyakova, Q. Wu, K. Mueller, S. Herzig, R. Jech, J. Diehl-Schmid, L. Riedl, S. Anderl-Straub, J. Kornhuber, K. Fassbender, J. Wiltfang, K. Fliessbach, J. Prudlo, M. Synofzik, A. Danek, M. Otto, ML. Schroeter, FTLD...

. 2024 ; 16 (1) : 237. [pub] 20241026

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25003789

Grant support
FTLDc 01GI1007A German Federal Ministry of Education and Research
FTLDc 01GI1007A German Federal Ministry of Education and Research
FTLDc 01GI1007A German Federal Ministry of Education and Research
01ED2008A EU Joint Program-Neurodegenerative Diseases networks Genfi-Prox
01EW2008 EU Moodmarker program
D.3830 Foundation of the state Baden-Württemberg
D.5009 Boehringer Ingelheim Ulm University BioCenter
D.2468 Fondation Thierry Latran
SCHR 774/5-1 Deutsche Forschungsgemeinschaft
project TelDem eHealthSax Initiative of the Sächsische Aufbaubank

Behavioral variant frontotemporal dementia (bvFTD) is characterized by profound and early deficits in social cognition (SC) and executive functions (EF). To date it remains unclear whether deficits of the respective cognitive domains are based on the degeneration of distinct brain regions. In 103 patients with a diagnosis of bvFTD (possible/probable/definite: N = 40/58/5) from the frontotemporal lobar degeneration (FTLD) consortium Germany cohort (age 62.5±9.4 years, gender 38 female/65 male) we applied multimodal structural imaging, i.e. voxel-based morphometry, cortical thickness (CTH) and networks of structural covariance via source based morphometry. We cross-sectionally investigated associations with performance in a modified Reading the Mind in the Eyes Test (RMET; reflective of theory of mind - ToM) and five different tests reflective of EF (i.e. Hamasch-Five-Point Test, semantic and phonemic Fluency, Trail Making Test, Stroop interference). Finally, we investigated the conjunction of RMET correlates with functional networks commonly associated with SC respectively ToM and EF as extracted meta-analytically within the Neurosynth database. RMET performance was mainly associated with gray matter volume (GMV) and CTH within temporal and insular cortical regions and less within the prefrontal cortex (PFC), whereas EF performance was mainly associated with prefrontal regions (GMV and CTH). Overlap of RMET and EF associations was primarily located within the insula, adjacent subcortical structures (i.e. putamen) and the dorsolateral PFC (dlPFC). These patterns were more pronounced after adjustment for the respective other cognitive domain. Corroborative results were obtained in analyses of structural covariance networks. Overlap of RMET with meta-analytically extracted functional networks commonly associated with SC, ToM and EF was again primarily located within the temporal and insular region and the dlPFC. In addition, on a meta-analytical level, strong associations were found for temporal cortical RMET correlates with SC and ToM in particular. These data indicate a temporo-frontal dissociation of bvFTD related disturbances of ToM and EF, with atrophy of the anterior temporal lobe being critically involved in ToM deficits. The consistent overlap within the insular cortex may be attributable to the multimodal and integrative role of this region in socioemotional and cognitive processing.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25003789
003      
CZ-PrNML
005      
20250206104714.0
007      
ta
008      
250121s2024 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s13195-024-01596-4 $2 doi
035    __
$a (PubMed)39462381
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Weise, Christopher M $u Department of Neurology, Halle University Medical Center, Halle (Saale), Germany. Christopher.weise@uk-halle.de
245    10
$a Dissecting neural correlates of theory of mind and executive functions in behavioral variant frontotemporal dementia / $c CM. Weise, A. Engel, M. Polyakova, Q. Wu, K. Mueller, S. Herzig, R. Jech, J. Diehl-Schmid, L. Riedl, S. Anderl-Straub, J. Kornhuber, K. Fassbender, J. Wiltfang, K. Fliessbach, J. Prudlo, M. Synofzik, A. Danek, M. Otto, ML. Schroeter, FTLD Consortium Germany
520    9_
$a Behavioral variant frontotemporal dementia (bvFTD) is characterized by profound and early deficits in social cognition (SC) and executive functions (EF). To date it remains unclear whether deficits of the respective cognitive domains are based on the degeneration of distinct brain regions. In 103 patients with a diagnosis of bvFTD (possible/probable/definite: N = 40/58/5) from the frontotemporal lobar degeneration (FTLD) consortium Germany cohort (age 62.5±9.4 years, gender 38 female/65 male) we applied multimodal structural imaging, i.e. voxel-based morphometry, cortical thickness (CTH) and networks of structural covariance via source based morphometry. We cross-sectionally investigated associations with performance in a modified Reading the Mind in the Eyes Test (RMET; reflective of theory of mind - ToM) and five different tests reflective of EF (i.e. Hamasch-Five-Point Test, semantic and phonemic Fluency, Trail Making Test, Stroop interference). Finally, we investigated the conjunction of RMET correlates with functional networks commonly associated with SC respectively ToM and EF as extracted meta-analytically within the Neurosynth database. RMET performance was mainly associated with gray matter volume (GMV) and CTH within temporal and insular cortical regions and less within the prefrontal cortex (PFC), whereas EF performance was mainly associated with prefrontal regions (GMV and CTH). Overlap of RMET and EF associations was primarily located within the insula, adjacent subcortical structures (i.e. putamen) and the dorsolateral PFC (dlPFC). These patterns were more pronounced after adjustment for the respective other cognitive domain. Corroborative results were obtained in analyses of structural covariance networks. Overlap of RMET with meta-analytically extracted functional networks commonly associated with SC, ToM and EF was again primarily located within the temporal and insular region and the dlPFC. In addition, on a meta-analytical level, strong associations were found for temporal cortical RMET correlates with SC and ToM in particular. These data indicate a temporo-frontal dissociation of bvFTD related disturbances of ToM and EF, with atrophy of the anterior temporal lobe being critically involved in ToM deficits. The consistent overlap within the insular cortex may be attributable to the multimodal and integrative role of this region in socioemotional and cognitive processing.
650    _2
$a lidé $7 D006801
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    12
$a frontotemporální demence $x patologie $x diagnostické zobrazování $x patofyziologie $x psychologie $7 D057180
650    12
$a exekutivní funkce $x fyziologie $7 D056344
650    12
$a teorie mysli $x fyziologie $7 D056345
650    _2
$a lidé středního věku $7 D008875
650    _2
$a senioři $7 D000368
650    12
$a magnetická rezonanční tomografie $7 D008279
650    12
$a neuropsychologické testy $7 D009483
650    _2
$a průřezové studie $7 D003430
650    _2
$a sociální kognice $7 D000083282
650    _2
$a mozek $x diagnostické zobrazování $x patologie $7 D001921
655    _2
$a časopisecké články $7 D016428
700    1_
$a Engel, Annerose $u Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany $u Clinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany
700    1_
$a Polyakova, Maryna $u Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
700    1_
$a Wu, Qiong $u Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
700    1_
$a Mueller, Karsten $u Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
700    1_
$a Herzig, Sabine $u Clinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany
700    1_
$a Jech, Robert $u Department of Neurology, Charles University in Prague, 1st Faculty of Medicine and General University Hospital in Prague, Prague, Czech Republic
700    1_
$a Diehl-Schmid, Janine $u Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany $u Clinical Center for Psychiatry, Psychotherapy, Psychosomatic Medicine, Geriatrics and Neurology, kbo-Inn-Salzach-Klinikum, Wasserburg/Inn, Germany
700    1_
$a Riedl, Lina $u Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany
700    1_
$a Anderl-Straub, Sarah $u Department of Neurology, University of Ulm, Ulm, Germany
700    1_
$a Kornhuber, Johannes $u Department of Psychiatry and Psychotherapy, University of Friedrich-Alexander-Erlangen, Erlangen, Germany
700    1_
$a Fassbender, Klaus $u Department of Neurology, Saarland University Hospital Homburg, Homburg, Germany
700    1_
$a Wiltfang, Jens $u Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany $u German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
700    1_
$a Fliessbach, Klaus $u German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany $u Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany
700    1_
$a Prudlo, Johannes $u German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany $u Department of Neurology, Rostock University Medical Center, Rostock, Germany
700    1_
$a Synofzik, Matthis $u German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany $u Department of Neurodegenerative Diseases, Center of Neurology, Hertie Institute for Clinical Brain Research, Tübingen, Germany
700    1_
$a Danek, Adrian $u Department of Neurology, Ludwig-Maximilians-University Munich, München, Germany
700    1_
$a Otto, Markus $u Department of Neurology, Halle University Medical Center, Halle (Saale), Germany
700    1_
$a Schroeter, Matthias L $u Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany $u Clinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, Germany
710    2_
$a FTLD Consortium Germany
773    0_
$w MED00172451 $t Alzheimer's research & therapy $x 1758-9193 $g Roč. 16, č. 1 (2024), s. 237
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39462381 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250121 $b ABA008
991    __
$a 20250206104709 $b ABA008
999    __
$a ok $b bmc $g 2263519 $s 1239796
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 16 $c 1 $d 237 $e 20241026 $i 1758-9193 $m Alzheimer's research & therapy $n Alzheimers Res Ther $x MED00172451
GRA    __
$a FTLDc 01GI1007A $p German Federal Ministry of Education and Research
GRA    __
$a FTLDc 01GI1007A $p German Federal Ministry of Education and Research
GRA    __
$a FTLDc 01GI1007A $p German Federal Ministry of Education and Research
GRA    __
$a 01ED2008A $p EU Joint Program-Neurodegenerative Diseases networks Genfi-Prox
GRA    __
$a 01EW2008 $p EU Moodmarker program
GRA    __
$a D.3830 $p Foundation of the state Baden-Württemberg
GRA    __
$a D.5009 $p Boehringer Ingelheim Ulm University BioCenter
GRA    __
$a D.2468 $p Fondation Thierry Latran
GRA    __
$a SCHR 774/5-1 $p Deutsche Forschungsgemeinschaft
GRA    __
$a project TelDem $p eHealthSax Initiative of the Sächsische Aufbaubank
LZP    __
$a Pubmed-20250121

Find record

Citation metrics

Archiving options