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Diagnosis of Alzheimer's Disease in Clinical Practice: Time to Incorporate Biomarkers
M. Vyhnalek, M. Laczó, J. Laczó
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
PubMed
39269843
DOI
10.3233/jad-240660
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc * diagnóza MeSH
- atrofie patologie MeSH
- biologické markery * MeSH
- hipokampus patologie diagnostické zobrazování MeSH
- lidé MeSH
- mozek patologie diagnostické zobrazování metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Hippocampal dysfunction is associated with early clinical signs of Alzheimer's disease (AD). Due to the limited availability or invasiveness of current biomarkers, the AD diagnosis is usually based on cognitive assessment and structural brain imaging. The recent study by Lalive and colleagues examined the specificity of brain morphometry for the AD diagnosis in a memory clinic cohort with hippocampal-type amnestic syndrome. The results indicate that memory deficits and hippocampal atrophy are similar in AD and non-AD patients, highlighting their low diagnostic specificity. These findings challenge the traditional AD diagnosis and underscore the need for biomarkers to differentiate specific neuropathological entities.
Citace poskytuje Crossref.org
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