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Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants
SR. McWhinney, C. Abé, M. Alda, F. Benedetti, E. Bøen, C. Del Mar Bonnin, T. Borgers, K. Brosch, EJ. Canales-Rodríguez, DM. Cannon, U. Dannlowski, AM. Diaz-Zuluaga, LMF. Dietze, T. Elvsåshagen, LT. Eyler, JM. Fullerton, JM. Goikolea, J....
Language English Country England, Great Britain
Document type Journal Article, Meta-Analysis
NLK
ProQuest Central
from 2001-01-01
Nursing & Allied Health Database (ProQuest)
from 2001-01-01
Health & Medicine (ProQuest)
from 2001-01-01
Psychology Database (ProQuest)
from 2001-01-01
- MeSH
- Bipolar Disorder * pathology diagnostic imaging MeSH
- Adult MeSH
- Body Mass Index * MeSH
- Middle Aged MeSH
- Humans MeSH
- Magnetic Resonance Imaging * MeSH
- Cerebral Cortex * diagnostic imaging pathology MeSH
- Obesity * pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
BACKGROUND: Obesity is highly prevalent and disabling, especially in individuals with severe mental illness including bipolar disorders (BD). The brain is a target organ for both obesity and BD. Yet, we do not understand how cortical brain alterations in BD and obesity interact. METHODS: We obtained body mass index (BMI) and MRI-derived regional cortical thickness, surface area from 1231 BD and 1601 control individuals from 13 countries within the ENIGMA-BD Working Group. We jointly modeled the statistical effects of BD and BMI on brain structure using mixed effects and tested for interaction and mediation. We also investigated the impact of medications on the BMI-related associations. RESULTS: BMI and BD additively impacted the structure of many of the same brain regions. Both BMI and BD were negatively associated with cortical thickness, but not surface area. In most regions the number of jointly used psychiatric medication classes remained associated with lower cortical thickness when controlling for BMI. In a single region, fusiform gyrus, about a third of the negative association between number of jointly used psychiatric medications and cortical thickness was mediated by association between the number of medications and higher BMI. CONCLUSIONS: We confirmed consistent associations between higher BMI and lower cortical thickness, but not surface area, across the cerebral mantle, in regions which were also associated with BD. Higher BMI in people with BD indicated more pronounced brain alterations. BMI is important for understanding the neuroanatomical changes in BD and the effects of psychiatric medications on the brain.
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Neurology Division of Clinical Neuroscience Oslo University Hospital Oslo Norway
Department of Neurology Institute of Clinical Medicine University of Oslo Oslo Norway
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry and Psychotherapy Philipps University Marburg Marburg Germany
Department of Psychiatry and Psychotherapy University Hospital Bonn Bonn Germany
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Erasmus University Medical Center Rotterdam The Netherlands
Department of Psychiatry Jena University Hospital Friedrich Schiller University Jena Jena Germany
Department of Psychiatry University of California San Diego La Jolla CA USA
Department of Psychiatry University of Münster Münster Germany
Desert Pacific MIRECC VA San Diego Healthcare San Diego CA USA
FIDMAG Germanes Hospitalàries Research Foundation Barcelona Spain
Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain
Institute for Translational Neuroscience University of Münster Münster Germany
Institute of Clinical Medicine University of Oslo Oslo Norway
Institute of Psychiartry King's College Londen London UK
Laureate Institute for Brain Research Tulsa OK USA
National Institute of Mental Health Klecany Czech Republic
Neuroscience Institute University of Cape Town Cape Town South Africa
Neuroscience Research Australia Randwick NSW Australia
Oxley College of Health Sciences The University of Tulsa Tulsa OK USA
Research Group Instituto de Alta Tecnología Médica Ayudas diagnósticas SURA Medellin Colombia
School of Medical Sciences University of New South Wales Sydney NSW Australia
School of Psychiatry University of New South Wales Sydney NSW Australia
UCLA Center for Neurobehavioral Genetics Los Angeles CA USA
University of British Columbia Vancouver BC Canada
Vita Salute San Raffaele University Milan Italy
West Region Institute of Mental Health Singapore Singapore
Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore
References provided by Crossref.org
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- $a Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants / $c SR. McWhinney, C. Abé, M. Alda, F. Benedetti, E. Bøen, C. Del Mar Bonnin, T. Borgers, K. Brosch, EJ. Canales-Rodríguez, DM. Cannon, U. Dannlowski, AM. Diaz-Zuluaga, LMF. Dietze, T. Elvsåshagen, LT. Eyler, JM. Fullerton, JM. Goikolea, J. Goltermann, D. Grotegerd, BCM. Haarman, T. Hahn, FM. Howells, M. Ingvar, N. Jahanshad, TTJ. Kircher, A. Krug, RT. Kuplicki, M. Landén, H. Lemke, B. Liberg, C. Lopez-Jaramillo, UF. Malt, FM. Martyn, E. Mazza, C. McDonald, G. McPhilemy, S. Meier, S. Meinert, T. Meller, EMT. Melloni, PB. Mitchell, L. Nabulsi, I. Nenadic, N. Opel, RA. Ophoff, BJ. Overs, JK. Pfarr, JA. Pineda-Zapata, E. Pomarol-Clotet, J. Raduà, J. Repple, M. Richter, KG. Ringwald, G. Roberts, A. Ross, R. Salvador, J. Savitz, S. Schmitt, PR. Schofield, K. Sim, DJ. Stein, F. Stein, HS. Temmingh, K. Thiel, SI. Thomopoulos, NEM. van Haren, C. Vargas, E. Vieta, A. Vreeker, L. Waltemate, LN. Yatham, CRK. Ching, OA. Andreassen, PM. Thompson, T. Hajek, ENIGMA Bipolar Disorder Working Group
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