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Association of Diabetic Ketoacidosis at Onset, Diabetes Technology Uptake, and Clinical Outcomes After 1 and 2 Years of Follow-up: A Collaborative Analysis of Pediatric Registries Involving 9,269 Children With Type 1 Diabetes From Nine Countries
K. Dovc, V. Neuman, G. Gita, V. Cherubini, GT. Alonso, M. Fritsch, C. Boettcher, C. de Beaufort, RW. Holl, M. de Bock
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
German Robert Koch Institute
P30-DK116073
NIH, NIDDK
P30 DK116073
NIDDK NIH HHS - United States
J3-4521
Slovenian Research Agency
82DZD14E03
German Center for Diabetes Research
NLK
Free Medical Journals
od 1978
Open Access Digital Library
od 1978-01-01 do Před 6 měsíci
Open Access Digital Library
od 2000-01-01 do Před 6 měsíci
Medline Complete (EBSCOhost)
od 1978-01-01
PubMed
39965057
DOI
10.2337/dc24-2483
Knihovny.cz E-zdroje
- MeSH
- diabetes mellitus 1. typu * epidemiologie komplikace krev MeSH
- diabetická ketoacidóza * epidemiologie MeSH
- dítě MeSH
- glykovaný hemoglobin metabolismus MeSH
- hypoglykemika terapeutické užití MeSH
- inzulin terapeutické užití MeSH
- inzulinové infuzní systémy MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- následné studie MeSH
- předškolní dítě MeSH
- registrace MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Itálie MeSH
- Lucembursko MeSH
- Německo MeSH
- Nový Zéland MeSH
- Rakousko MeSH
- Slovinsko MeSH
- Švýcarsko MeSH
OBJECTIVE: This study examined the association between diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis and long-term glycemic outcomes, insulin requirements, BMI SD score (SDS), and diabetes technology uptake in youth. RESEARCH DESIGN AND METHODS: Data were from nine countries (Austria, Czechia, Germany, Italy, Luxembourg, New Zealand, Slovenia, Switzerland, and U.S. [Colorado]), including youth (0.5-15.9 years) diagnosed with type 1 diabetes in 2019-2020 and followed for 2 years thereafter. Participants were divided into three groups: no DKA, nonsevere, and severe DKA at diagnosis. HbA1c, insulin requirements, BMI SDS, and use of technology, including automated insulin delivery (AID), were assessed. RESULTS: The analysis included 9,269 individuals (54.8% males, mean age 9.0 years). DKA at diagnosis was observed in 34.2% of participants and severe DKA in 12.8%. After 1 year, adjusted mean HbA1c was higher in the severe DKA group (7.41%) compared with nonsevere DKA (7.23%, P = 0.001) and no DKA groups (7.14, P < 0.001), and this difference persisted after 2 years (7.58% vs. 7.38% [P < 0.001] and vs. 7.32% [P < 0.001]). Higher BMI SDS was observed in both DKA groups compared with no DKA. The use of AID was associated with lower HbA1c levels compared with other treatment modalities and moderated differences between DKA groups after 2 years of follow-up (P = 0.072). CONCLUSIONS: Severe and nonsevere DKA at type 1 diabetes diagnosis were both associated with persistently higher HbA1c and higher BMI SDS. AID use diminishes the association of DKA at diagnosis and higher HbA1c over time.
Barbara Davis Center University of Colorado Anschutz Medical Campus Aurora CO
Department of Pediatrics and Adolescent Medicine Medical University Graz Graz Austria
Department of Pediatrics University of Otago Christchurch New Zealand
Department of Women's and Children's Health Salesi Hospital Ancona Italy
Faculty of Science Technology and Medicine University of Luxembourg Esch Belval Luxembourg
Institute of Epidemiology and Medical Biometry Munich Neuherberg Germany
Citace poskytuje Crossref.org
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