-
Je něco špatně v tomto záznamu ?
External validation of an algorithm to personalize nerve sparing approaches during robot-assisted radical prostatectomy in men with unilateral high-risk prostate cancer
L. Rodriguez-Sanchez, A. Martini, J. Zhuang, H. Guo, P. Rajwa, Q. Mandoorah, L. Haiquel, SF. Shariat, G. Gandaglia, M. Valerio, G. Marra, Young Academic Urologists Working Group on Prostate Cancer of the European Association of Urology
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, validační studie
- MeSH
- algoritmy * MeSH
- hodnocení rizik metody MeSH
- léčba šetřící orgány * metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory prostaty * chirurgie patologie MeSH
- nomogramy MeSH
- prostata chirurgie inervace patologie MeSH
- prostatektomie * metody MeSH
- roboticky asistované výkony * metody MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- validační studie MeSH
Limited evidence exists about preserving neurovascular bundles during radical prostatectomy (RP) for high-risk prostate cancer (HRPCa) patients. Hence, we validated an existing algorithm predicting contralateral extraprostatic extension (cEPE) risk in unilateral high-risk cases. This algorithm aims to assist in determining the suitability of unilateral nerve-sparing RP. Among 264 patients, 48 (18%) had cEPE. The risk of cECE varied: 8%, 17.2%, and 30.8% for the low, intermediate, and high-risk groups, respectively. Despite a higher risk of cECE among individuals classified as low-risk in the development group compared to the validation group, our algorithm's superiority over always/never nerve-sparing RP was reaffirmed by decision curve analysis. Therefore, we conclude that bilateral excision may not always be justified in men with unilateral HRPCa. Instead, decisions can be based on our suggested nomogram.
Department of Urology 2nd Faculty of Medicine Charles University Prague Czech Republic
Department of Urology Comprehensive Cancer Center Medical University of Vienna Vienna Austria
Department of Urology Geneva University Hospital Geneva Switzerland
Department of Urology Institut Mutualiste Montsouris Paris France
Department of Urology Medical University of Silesia Zabrze Poland
Department of Urology San Giovanni Battista Hospital University of Turin Turin Italy
Department of Urology University of Texas Southwestern Dallas TX USA
Department of Urology Weill Cornell Medical College New York NY USA
Hourani Center for Applied Scientific Research Al Ahliyya Amman University Amman Jordan
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25009780
- 003
- CZ-PrNML
- 005
- 20250429134945.0
- 007
- ta
- 008
- 250415s2025 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41391-023-00779-8 $2 doi
- 035 __
- $a (PubMed)38177256
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Rodriguez-Sanchez, Lara $u Department of Urology, Institut Mutualiste Montsouris, Paris, France. lara.rodriguez-sanchez@imm.fr $1 https://orcid.org/0000000169392645
- 245 10
- $a External validation of an algorithm to personalize nerve sparing approaches during robot-assisted radical prostatectomy in men with unilateral high-risk prostate cancer / $c L. Rodriguez-Sanchez, A. Martini, J. Zhuang, H. Guo, P. Rajwa, Q. Mandoorah, L. Haiquel, SF. Shariat, G. Gandaglia, M. Valerio, G. Marra, Young Academic Urologists Working Group on Prostate Cancer of the European Association of Urology
- 520 9_
- $a Limited evidence exists about preserving neurovascular bundles during radical prostatectomy (RP) for high-risk prostate cancer (HRPCa) patients. Hence, we validated an existing algorithm predicting contralateral extraprostatic extension (cEPE) risk in unilateral high-risk cases. This algorithm aims to assist in determining the suitability of unilateral nerve-sparing RP. Among 264 patients, 48 (18%) had cEPE. The risk of cECE varied: 8%, 17.2%, and 30.8% for the low, intermediate, and high-risk groups, respectively. Despite a higher risk of cECE among individuals classified as low-risk in the development group compared to the validation group, our algorithm's superiority over always/never nerve-sparing RP was reaffirmed by decision curve analysis. Therefore, we conclude that bilateral excision may not always be justified in men with unilateral HRPCa. Instead, decisions can be based on our suggested nomogram.
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a nádory prostaty $x chirurgie $x patologie $7 D011471
- 650 12
- $a prostatektomie $x metody $7 D011468
- 650 12
- $a algoritmy $7 D000465
- 650 12
- $a roboticky asistované výkony $x metody $7 D065287
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a léčba šetřící orgány $x metody $7 D059351
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a nomogramy $7 D049451
- 650 _2
- $a prostata $x chirurgie $x inervace $x patologie $7 D011467
- 650 _2
- $a hodnocení rizik $x metody $7 D018570
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a validační studie $7 D023361
- 700 1_
- $a Martini, Alberto $u Division of Oncology/Unit of Urology, Soldera Prostate Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy $u Vita-Salute San Raffaele University, Milan, Italy
- 700 1_
- $a Zhuang, Junlong $u Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu, PR China
- 700 1_
- $a Guo, Hongqiao $u Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing, Jiangsu, PR China
- 700 1_
- $a Rajwa, Pawel $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria $u Department of Urology, Medical University of Silesia, Zabrze, Poland $1 https://orcid.org/0000000340736584
- 700 1_
- $a Mandoorah, Qusay $u Department of Urology, Institut Mutualiste Montsouris, Paris, France
- 700 1_
- $a Haiquel, Luciano $u Department of Urology, Institut Mutualiste Montsouris, Paris, France
- 700 1_
- $a Shariat, Shahrokh F $u Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria $u Department of Urology, Weill Cornell Medical College, New York, NY, USA $u Department of Urology, Second Faculty of Medicine, Charles University, Prague, Czech Republic $u Department of Urology, University of Texas Southwestern, Dallas, TX, USA $u Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan
- 700 1_
- $a Gandaglia, Giorgio $u Division of Oncology/Unit of Urology, Soldera Prostate Cancer Lab, URI, IRCCS Ospedale San Raffaele, Milan, Italy
- 700 1_
- $a Valerio, Massimo $u Department of Urology, Geneva University Hospital, Geneva, Switzerland
- 700 1_
- $a Marra, Giancarlo $u Department of Urology, San Giovanni Battista Hospital, University of Turin, Turin, Italy
- 710 2_
- $a Young Academic Urologists Working Group on Prostate Cancer of the European Association of Urology
- 773 0_
- $w MED00008064 $t Prostate cancer and prostatic diseases $x 1476-5608 $g Roč. 28, č. 1 (2025), s. 223-225
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/38177256 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250415 $b ABA008
- 991 __
- $a 20250429134941 $b ABA008
- 999 __
- $a ok $b bmc $g 2311268 $s 1246861
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 28 $c 1 $d 223-225 $e 20240104 $i 1476-5608 $m Prostate cancer and prostatic diseases $n Prostate Cancer Prostatic Dis $x MED00008064
- LZP __
- $a Pubmed-20250415
