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RENEB interlaboratory comparison for biological dosimetry based on dicentric chromosome analysis and cobalt-60 exposures higher than 2.5 Gy
M. Bucher, D. Endesfelder, S. Pojtinger, A. Baeyens, JF. Barquinero, C. Beinke, L. Bobyk, E. Gregoire, R. Hristova, JS. Martinez, PK. Meher, M. Milanova, OM. Gil, A. Montoro, J. Moquet, M. Moreno Domene, MJ. Prieto, M. Pujol-Canadell, M. Sun, GI....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, srovnávací studie
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
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od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-12-01
- MeSH
- chromozomální aberace * účinky záření MeSH
- dávka záření MeSH
- laboratoře normy MeSH
- lidé MeSH
- radioizotopy kobaltu * MeSH
- radiometrie * metody MeSH
- vztah dávky záření a odpovědi MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
In previous RENEB interlaboratory comparisons based on the manual scoring of dicentric chromosomes, a tendency for systematic overestimation for doses > 2.5 Gy was found. However, these exercises included only very few doses in the high dose range, and they were heterogeneous in terms of radiation quality and evaluation mode, and comparable only to a limited extent. Here, this presumed deviation was explored by investigating three doses > 2.5 Gy. Blood samples were irradiated (2.56, 3.41 and 4.54 Gy) using a 60Co source and sent to 14 member laboratories of the RENEB network, which performed the dicentric chromosome assay (manual and/or semi-automatic scoring) and reported dose estimates. Most participants provided estimates that agreed very well with the physical reference doses and all provided dose estimates were in the correct clinical category (> 2 Gy). The previously observed tendency for a systematic bias across all laboratories was not confirmed. However, tendencies for systematic underestimation were detected for dose estimations for reference doses given in terms of absorbed dose to blood and for some participants, a laboratory-specific trend of systematic under- or overestimation was observed. The importance of regularly performed quality checks for a broad dose range became obvious to avoid misinterpretation of results.
Bundeswehr Institute of Radiobiology Munich Germany
Radiobiology Department National Centre of Radiobiology and Radiation Protection Sofia Bulgaria
Radiobiology Lab Department of Human Structure and Repair Ghent University Gent Belgium
Citace poskytuje Crossref.org
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