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Comparative analysis of COVID-19-associated venous thromboembolism outcomes: evolution from 2020 to 2021-2022

F. Galeano-Valle, P. Demelo-Rodríguez, R. Alonso-Beato, JM. Pedrajas, JL. Fernández-Reyes, R. Chopard, P. Sadeghipour, J. Hirmerova, B. Bikdeli, M. Monreal, RIETE Investigators

. 2024 ; 57 (7) : 1239-1248. [pub] 20240729

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články, srovnávací studie

Perzistentní odkaz   https://www.medvik.cz/link/bmc25004046
E-zdroje Online Plný text

NLK ProQuest Central od 1998-06-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2011-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 1998-06-01 do Před 1 rokem

Odkazy

PubMed 39078534
DOI 10.1007/s11239-024-03026-6
Knihovny.cz E-zdroje

Patients with COVID-19 are at an increased risk for venous thromboembolism (VTE). With the advent of vaccinations and novel treatments from 2020 through 2022, the landscape of COVID-19 has evolved. Notably, the effects of such interventions on the outcomes of COVID-19-associated VTE have not been thoroughly examined. Data from the RIETE registry were analyzed to evaluate 90-day VTE-related outcomes (all-cause mortality, major bleeding, and VTE recurrences) in patients with COVID-19-associated VTE. We compared the periods before and after the widespread introduction of COVID-19 vaccines: March to December 2020 (pre-vaccine period) and March 2021 to December 2022 (post-vaccine period). Statistical analysis included mixed-effects parametric survival-time models. Among 1,620 patients with COVID-19-associated VTE, most (74.1%) were identified during 2020 period. The analysis revealed a more than two-fold increase in the risk of death within 90 days (adjusted hazard ratio [HR]: 2.27; 95% confidence interval, CI: 1.18-4.38) and major bleeding (adjusted HR: 2.91; 95%CI: 1.08-7.84) for patients from the 2020 period compared to those from the 2021-2022 period. Inpatient subgroup analysis confirmed the observed mortality differences. The frequency of recurrent VTE was low (1.1 vs. 0.7%, respectively), and did not show significant variation between the two periods. Our research provides a comparative perspective on the clinical outcomes of COVID-19-associated VTE before and after the introduction of vaccines. Our findings reveal a significant decrease in the incidence of 90-day mortality and major bleeding in patients with COVID-19-associated VTE in the 2021-2022 period.

Citace poskytuje Crossref.org

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