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Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions
AA. Lamoureux, MJ. Fisher, L. Lemelle, E. Pfaff, P. Amir-Yazdani, C. Kramm, B. De Wilde, B. Kazanowska, C. Hutter, SM. Pfister, D. Sturm, DTW. Jones, D. Orbach, G. Pierron, S. Raskin, A. Drilon, EL. Diamond, G. Harada, M. Zapotocky, J. Zamecnik,...
Language English Country United States
Document type Journal Article
Grant support
P30 CA008748
NCI NIH HHS - United States
R01 CA273224
NCI NIH HHS - United States
R37 CA259260
NCI NIH HHS - United States
1R01CA251591001A1
National Cancer Institute (NCI)
NLK
Freely Accessible Science Journals
from 1995
Open Access Digital Library
from 1995-01-01
Open Access Digital Library
from 1995-01-01
- MeSH
- Child MeSH
- Adult MeSH
- Gene Fusion MeSH
- Oncogene Proteins, Fusion * genetics MeSH
- Glioma * genetics pathology mortality therapy MeSH
- Protein Kinase Inhibitors therapeutic use MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Membrane Glycoproteins MeSH
- Adolescent MeSH
- Young Adult MeSH
- Central Nervous System Neoplasms * genetics therapy mortality pathology MeSH
- Child, Preschool MeSH
- Prognosis MeSH
- Pyrazoles therapeutic use MeSH
- Pyrimidines therapeutic use MeSH
- Receptor, trkA * genetics antagonists & inhibitors MeSH
- Receptor, trkB genetics antagonists & inhibitors MeSH
- Receptor, trkC genetics antagonists & inhibitors MeSH
- Retrospective Studies MeSH
- Aged MeSH
- Neoplasm Grading MeSH
- Treatment Outcome MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
PURPOSE: Tropomyosin receptor kinase (TRK) fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients. EXPERIMENTAL DESIGN: We conducted an international retrospective cohort study of patients with TRK fusion-driven central nervous system tumors. RESULTS: A total of 119 patients were identified. The median age at the time of diagnosis was 4.5 years. The majority were reported to have a histology consistent with a diagnosis of high-grade glioma (HGG; 57.1%) followed by low-grade glioma (LGG; 27.7%). Pediatric patients had a better prognosis, with a median overall survival of 185.5 months compared with 24.8 months in adults (P < 0.0001). Patients with LGG also had a better outcome when compared with HGG (P = 0.0012). The objective response was 68.8% with larotrectinib compared with 38.1% for nontargeted treatment. CONCLUSIONS: Children with LGG had a favorable outcome compared with adult glioma and HGG. TRK inhibitors seem to improve tumor control.
Aga Khan University Hospital Karachi Pakistan
American University of Beirut Medical Center Beirut Lebanon
Arnold Palmer Hospital Orlando Florida
B C Children's Hospital Vancouver British Columbia Canada
Cancer Immunology Program Peter MacCallum Cancer Centre Melbourne Victoria Australia
Children's Cancer Centre Royal Children's Hospital Parkville Victoria Australia
Children's Cancer Institute Lowy Cancer Centre UNSW Sydney Sydney New South Wales Australia
Children's Health Care of Atlanta Emory University School of Medicine Atlanta Georgia
Children's Hospital Los Angeles Los Angeles California
Children's Hospital of Orange County Orange California
Children's Minnesota Minneapolis Minnesota
Children's National Hospital Washington District of Columbia
CHU Hôpital Saint André Bordeaux France
Cliniques Universitaires Saint Luc Brussels Belgium
Department of Neurosciences University of Montreal CHU Sainte Justine Montreal Quebec Canada
Department of Oncology DCCC Brain Tumor Center Rigshospitalet Copenhagen Denmark
Department of Oncology University Children's Hospital Zurich Switzerland
Department of Pediatric Hematology Oncology and BMT Wroclaw Medical University Wroclaw Poland
Department of Pediatrics St Anna Children's Hospital Medical University of Vienna Vienna Austria
Department of Pediatrics University of Minnesota Minneapolis Minnesota
Division of Neurosurgery Children's Hospital of Philadelphia Philadelphia Pennsylvania
Division of Oncology Children's Hospital of Philadelphia Philadelphia Pennsylvania
Division of Pediatric Glioma Research Hopp Children's Cancer Center Heidelberg Germany
Division of Pediatric Hematology and Oncology University Medical Center Göttingen Göttingen Germany
Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy
German Cancer Research Center Heidelberg Germany
Ghent University Hospital Ghent Belgium
Gustave Roussy Cancer Center Université Paris Saclay Villejuif France
Hematology Department Faculty of Medicine King Abdulaziz University Jeddah Saudia Arabia
Hospices Civils de Lyon Lyon France
Hospital for Sick Children Toronto Ontario Canada
Hospital Infantil Universitario Niño Jesús Madrid Spain
Institut Bergonié Bordeaux France
IOP GRAACC UNIFESP Sao Paulo Brasil
IWK Health Centre Halifax Nova Scotia Canada
Kanagawa Children's Medical Center Yokohama Japan
Karolinska University Hospital Stockholm Sweden
Kids Cancer Centre Sydney Children's Hospital Randwick New South Wales Australia
Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College New York New York
Michael Rice Centre for Hematology and Oncology Adelaide South Australia Australia
Monash Children's Hospital Clayton Victoria Australia
Monash University Clayton Victoria Australia
Montreal Children's Hospital Montréal Quebec Canada
Murdoch Children's Research Institute Melbourne Victoria Australia
Nemour Alfred 1 du Pont Hospital for Children Wilmington Delaware
Phoenix Children's Hospital Phoenix Arizona
School of Clinical Medicine UNSW Medicine and Health UNSW Sydney Sydney New South Wales Australia
SIREDO Oncology Center PSL Research University Institut Curie Paris France
South Australia Health and Medical Research Institute Adelaide South Australia Australia
St Anna Children's Cancer Research Institute Vienna Austria
Taipei Medical University Taipei Taiwan
Texas Children's Hospital Houston Texas
The Hudson Institute of Medical Research Clayton Victoria Australia
The Institute of Cancer Research London United Kingdom
University of California San Francisco San Francisco California
University of Michigan Ann Arbor Michigan
References provided by Crossref.org
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