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Increased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment
K. Bolsewig, EAJ. Willemse, P. Sánchez-Juan, A. Rábano, M. Martínez, JD. Doecke, G. Bellomo, L. Vermunt, D. Alcolea, S. Halbgebauer, S. In 't Veld, N. Mattsson-Carlgren, K. Veverova, CJ. Fowler, L. Boonkamp, M. Koel-Simmelink, Z. Hussainali, DN....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie
Grantová podpora
R21 AG056974
NIA NIH HHS - United States
RF1 AG056850
NIA NIH HHS - United States
RF1 AG061566
NIA NIH HHS - United States
860197
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- biologické markery * krev mozkomíšní mok MeSH
- demence s Lewyho tělísky * farmakoterapie krev mozkomíšní mok MeSH
- DOPA-dekarboxylasa * metabolismus MeSH
- dopaminové látky terapeutické užití MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- Parkinsonova nemoc * farmakoterapie krev mozkomíšní mok MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
DOPA Decarboxylase (DDC) has been proposed as a cerebrospinal fluid (CSF) biomarker with increased concentrations in Lewy body disorders (LBDs) and highest levels in patients receiving dopaminergic treatment. Here we evaluate plasma DDC, measured by proximity extension assay, and the effect of dopaminergic treatment in three independent LBD (with a focus on dementia with Lewy bodies (DLB) and Parkinson's disease (PD)) cohorts: an autopsy-confirmed cohort (n = 71), a large multicenter, cross-dementia cohort (n = 1498) and a longitudinal cohort with detailed treatment information (n = 66, median follow-up time[IQR] = 4[4, 4] years). Plasma DDC was not altered between different LBDs and other disease groups or controls in absence of treatment. DDC levels increased over time in PD, being significantly associated to higher dosages of dopaminergic treatment. This emphasizes the need to consider treatment effect when analyzing plasma DDC, and suggests that plasma DDC, in contrast to CSF DDC, is of limited use as a diagnostic biomarker for LBD, but could be valuable for treatment monitoring.
Alzheimer's Centre Reina Sofia CIEN Foundation ISCIII Madrid Spain
Amsterdam Neuroscience Neurodegeneration program Amsterdam UMC Amsterdam The Netherlands
Australian E Health Research Centre CSIRO Herston QLD Australia
Barcelonaβeta Brain Research Center Pasqual Maragall Foundation Barcelona Spain
Clinical Memory Research Unit Lund University Lund Sweden
Department of Clinical Research University Hospital Basel University of Basel Basel Switzerland
Department of Neurology Alzheimer Center Amsterdam Amsterdam UMC Amsterdam The Netherlands
Department of Neurology University Hospital and University of Basel Basel Switzerland
Department of Neurology University Hospital Ulm Ulm Germany
Florey Institute The University of Melbourne Melbourne VIC Australia
German Center for Neurodegenerative Diseases Ulm Germany
Hospital del Mar Research Institute Barcelona Spain
Neurology Clinic Skåne University Hospital Lund Sweden
Wallenberg Center for Molecular Medicine Lund University Lund Sweden
Citace poskytuje Crossref.org
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