Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Number of children and dementia risk: a causal mediation analysis using data from the HUNT study linked with national registries in Norway

T. Mekonnen, V. Skirbekk, E. Zotcheva, B. Engdahl, B. Bratsberg, A. Jugessur, C. Bowen, G. Selbæk, HP. Kohler, JR. Harris, SE. Tom, S. Krokstad, TH. Edwin, Y. Wedatilake, K. Wolfova, D. Kristjansson, Y. Stern, AK. Håberg, BH. Strand

. 2025 ; 25 (1) : 39. [pub] 20250127

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25010176

Grantová podpora
R01 AG069109 NIA NIH HHS - United States
project number 262700. Research Council of Norway
R01AG069109-01 National Institutes of Health (NIH), R01 grant

BACKGROUND: Childlessness, as well as having a high number of children, has been reported to be associated with an elevated risk of dementia compared to having 2-3 children. The mechanisms underlying these relationships are not well understood and may be mediated by different midlife risk factors. We examined the mediating role of various factors on the relationship between the number of children and dementia risk. These factors include socioeconomic factors (e.g., occupational complexity), psychosocial (e.g.., social activities, loneliness, life satisfaction), lifestyle (e.g., smoking, physical inactivity, alcohol intake), and chronic diseases (e.g., obesity, diabetes, depression, hearing impairment and hypertension). METHODS: Using a historic cohort design, we included 9,745 participants born between 1931-48, with a mean age of 78.2 (SD = 6.4) years at the time of cognitive testing in the HUNT4 70 + sub-study (2017-2019). Further measures were obtained through data linkage between information from Statistics Norway and the HUNT1(1984-86), and HUNT2 (1995-97) Surveys. Causal mediation analyses using an inverse odd weighting approach were conducted to decompose the total effect of the number of children (0, 1, or 4 + children vs. 2-3) on the risk of dementia at age 70 + years into direct and indirect effects with mediators assessed at a mean age of 50.7 (SD = 6.4) years. The analyses were adjusted for age, sex, marital status at age 25 years, educational status, and religion assessed during HUNT3 (2006-2008). RESULTS: Overall, 15.7% were diagnosed with dementia. The proportions with dementia by the number of children were 22.3% among those with no children, 21.4% for those with one child, 13% for those with 2-3 children (specifically, 12.6% for those with 2 children and 13.4% for those with 3 children), and 19.9% for those with 4 + children. Compared to the reference group of individuals with 2-3 children, the dementia risk was higher among the groups with no children (relative risk (RR): 1.30, 95% confidence interval (CI) (1.12, 1.51)), those with one child (RR: 1.30, 95% CI (1.14, 1.47)) and those with 4 + children (RR: 1.12, 95% CI (1.01, 1.24)). The elevated risks of dementia were not mediated by the socioeconomic, psychosocial, lifestyle, or chronic diseases related factors that we tested. Sex-stratified analysis showed higher dementia risk for men without children and women with one or 4 + children compared to those with 2-3 children, with similar patterns across sexes. None of the mediators contributed to mediation in either group. None of the mediators appeared to contribute through mediation in either group. CONCLUSIONS: Our findings suggest that the number of children-specifically being childless, having one child, or having four or more children-may influence the risk of dementia. These relationships were not mediated by psychosocial, lifestyle, and socioeconomic factors, or markers of chronic diseases in adulthood considered in this study.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25010176
003      
CZ-PrNML
005      
20250429134950.0
007      
ta
008      
250415s2025 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12883-025-04044-4 $2 doi
035    __
$a (PubMed)39871199
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Mekonnen, Teferi $u Department for Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway. teferimekonnen.yitayew@fhi.no
245    10
$a Number of children and dementia risk: a causal mediation analysis using data from the HUNT study linked with national registries in Norway / $c T. Mekonnen, V. Skirbekk, E. Zotcheva, B. Engdahl, B. Bratsberg, A. Jugessur, C. Bowen, G. Selbæk, HP. Kohler, JR. Harris, SE. Tom, S. Krokstad, TH. Edwin, Y. Wedatilake, K. Wolfova, D. Kristjansson, Y. Stern, AK. Håberg, BH. Strand
520    9_
$a BACKGROUND: Childlessness, as well as having a high number of children, has been reported to be associated with an elevated risk of dementia compared to having 2-3 children. The mechanisms underlying these relationships are not well understood and may be mediated by different midlife risk factors. We examined the mediating role of various factors on the relationship between the number of children and dementia risk. These factors include socioeconomic factors (e.g., occupational complexity), psychosocial (e.g.., social activities, loneliness, life satisfaction), lifestyle (e.g., smoking, physical inactivity, alcohol intake), and chronic diseases (e.g., obesity, diabetes, depression, hearing impairment and hypertension). METHODS: Using a historic cohort design, we included 9,745 participants born between 1931-48, with a mean age of 78.2 (SD = 6.4) years at the time of cognitive testing in the HUNT4 70 + sub-study (2017-2019). Further measures were obtained through data linkage between information from Statistics Norway and the HUNT1(1984-86), and HUNT2 (1995-97) Surveys. Causal mediation analyses using an inverse odd weighting approach were conducted to decompose the total effect of the number of children (0, 1, or 4 + children vs. 2-3) on the risk of dementia at age 70 + years into direct and indirect effects with mediators assessed at a mean age of 50.7 (SD = 6.4) years. The analyses were adjusted for age, sex, marital status at age 25 years, educational status, and religion assessed during HUNT3 (2006-2008). RESULTS: Overall, 15.7% were diagnosed with dementia. The proportions with dementia by the number of children were 22.3% among those with no children, 21.4% for those with one child, 13% for those with 2-3 children (specifically, 12.6% for those with 2 children and 13.4% for those with 3 children), and 19.9% for those with 4 + children. Compared to the reference group of individuals with 2-3 children, the dementia risk was higher among the groups with no children (relative risk (RR): 1.30, 95% confidence interval (CI) (1.12, 1.51)), those with one child (RR: 1.30, 95% CI (1.14, 1.47)) and those with 4 + children (RR: 1.12, 95% CI (1.01, 1.24)). The elevated risks of dementia were not mediated by the socioeconomic, psychosocial, lifestyle, or chronic diseases related factors that we tested. Sex-stratified analysis showed higher dementia risk for men without children and women with one or 4 + children compared to those with 2-3 children, with similar patterns across sexes. None of the mediators contributed to mediation in either group. None of the mediators appeared to contribute through mediation in either group. CONCLUSIONS: Our findings suggest that the number of children-specifically being childless, having one child, or having four or more children-may influence the risk of dementia. These relationships were not mediated by psychosocial, lifestyle, and socioeconomic factors, or markers of chronic diseases in adulthood considered in this study.
650    _2
$a lidé $7 D006801
650    12
$a demence $x epidemiologie $7 D003704
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a senioři $7 D000368
650    _2
$a rizikové faktory $7 D012307
650    12
$a analýza mediace $7 D000081983
650    12
$a registrace $x statistika a číselné údaje $7 D012042
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a kohortové studie $7 D015331
650    _2
$a socioekonomické faktory $7 D012959
650    _2
$a lidé středního věku $7 D008875
650    _2
$a životní styl $7 D008019
650    _2
$a charakteristiky rodiny $7 D005191
651    _2
$a Norsko $x epidemiologie $7 D009664
655    _2
$a časopisecké články $7 D016428
700    1_
$a Skirbekk, Vegard $u Department for Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway $u Norwegian National Centre of Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway $u Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Zotcheva, Ekaterina $u Department for Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway $u Norwegian National Centre of Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway
700    1_
$a Engdahl, Bo $u Department for Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Bratsberg, Bernt $u Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway $u Ragnar Frisch Center for Economic Research, Oslo, Norway
700    1_
$a Jugessur, Astanand $u Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway $u Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
700    1_
$a Bowen, Catherine $u Independent Researcher, Vienna, Austria
700    1_
$a Selbæk, Geir $u Norwegian National Centre of Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway $u Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway $u Faculty of Medicine, University of Oslo, Oslo, Norway
700    1_
$a Kohler, Hans-Peter $u Population Aging Research Center and Department of Sociology, University of Pennsylvania, Philadelphia, PA, USA
700    1_
$a Harris, Jennifer R $u Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Tom, Sarah E $u Department of Neurology, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA $u Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA
700    1_
$a Krokstad, Steinar $u Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology, Trondheim, Norway $u Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
700    1_
$a Edwin, Trine Holt $u Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
700    1_
$a Wedatilake, Yehani $u Norwegian National Centre of Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway
700    1_
$a Wolfova, Katrin $u Department of Neurology, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA $u Department of Epidemiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Kristjansson, Dana $u Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway $u Department of Genetics and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway
700    1_
$a Stern, Yaakov $u Department of Neurology, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA
700    1_
$a Håberg, Asta Kristine $u Department for Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway $u Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway
700    1_
$a Strand, Bjørn Heine $u Department for Physical Health and Aging, Norwegian Institute of Public Health, Oslo, Norway $u Norwegian National Centre of Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway $u Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway
773    0_
$w MED00008195 $t BMC neurology $x 1471-2377 $g Roč. 25, č. 1 (2025), s. 39
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39871199 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250415 $b ABA008
991    __
$a 20250429134946 $b ABA008
999    __
$a ok $b bmc $g 2311515 $s 1247257
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 25 $c 1 $d 39 $e 20250127 $i 1471-2377 $m BMC neurology $n BMC Neurol $x MED00008195
GRA    __
$a R01 AG069109 $p NIA NIH HHS $2 United States
GRA    __
$a project number 262700. $p Research Council of Norway
GRA    __
$a R01AG069109-01 $p National Institutes of Health (NIH), R01 grant
LZP    __
$a Pubmed-20250415

Najít záznam

Citační ukazatele

Možnosti archivace