OBJECTIVES: This study aims to explore the lasting effects of stress experienced by pregnant women during World War II (WWII) on body and head measurements of their adult daughters. METHODS: The research sample consists of 336 female university students born in Poland between 1925 and 1951. The data include body measurements and socioeconomic information (parental occupation and number of siblings) acquired from questionnaires collected between the 1950s and 1970s. Student's t-test, Mann-Whitney test and Analysis of Variance were used to analyze differences in body measurements between groups of women born before and during the war, as well as the possible influences of socioeconomic variables. RESULTS: The mean measurements of body height, symphysion height, and waist circumference were lower in women conceived and born during the war compared to those born in the pre-war period. In contrast, the mean measurements of biacromial (shoulder) width, trunk length, and three head dimensions were higher in women conceived and born during the war. Additionally, the number of siblings appeared to be a significant factor that may have influenced the body measurements of women in both groups. For instance, a higher number of living siblings, particularly sisters, was associated with reduced body dimensions, such as body height and waist circumference, while a greater number of deceased siblings was linked to an increase in certain body dimensions. CONCLUSION: The results suggest that war-related prenatal conditions may have influenced the postnatal growth and development of women conceived and born during the war. Notably, the direction of these changes varied, which indicates that the growth response to the war-related conditions was a complex adaptation, reflecting both positive and negative changes in different body parts, rather than a uniform pattern of growth suppression.

• MeSH
• 2. světová válka * MeSH
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• psychický stres MeSH
• socioekonomické faktory MeSH
• těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Polsko MeSH

Publikace obsahuje úplné znění aktuálních českých zákonů a předpisů, které se zaměřují na cestovní náhrady a odměňování v zaměstnání. Určeno odborné veřejnosti.

• Klíčová slova
• pracovní právo,
• MeSH
• cestování ekonomika   zákonodárství a právo   MeSH
• kompenzace a odškodnění zákonodárství a právo   MeSH
• mzdy a přídavky zákonodárství a právo   MeSH
• podnikání zákonodárství a právo   MeSH
• zaměstnanost zákonodárství a právo   MeSH
• Geografické názvy
• Česká republika MeSH

• Konspekt
• Právo
• NLK Obory
• právo, zákonodárství
• ekonomie, ekonomika, ekonomika zdravotnictví
• NLK Publikační typ
• zákony
• právní předpisy

OBJECTIVES: Olfactory dysfunction (OD) is common and carries significant personal and societal burden. Accurate assessment is necessary for good clinical and research practice but is highly dependent on the assessment technique used. Current practice with regards to UK/international clinical assessment is unknown. We aimed to capture current clinical practice, with reference to contemporaneously available guidelines. We further aimed to compare UK to international practice. DESIGN: Anonymous online questionnaire with cross-sectional non-probability sampling. Subgroup analysis according to subspeciality training in rhinology ('rhinologists' and 'non-rhinologists') was performed, with geographical comparisons only made according to subgroup. PARTICIPANTS: ENT surgeons who assess olfaction. RESULTS: Responses were received from 465 clinicians (217 from UK and 17 countries total). Country-specific response rate varied, with the lowest rate being obtained from Japan (1.4%) and highest from Greece (72.5%). Most UK clinicians do not perform psychophysical smell testing during any of the presented clinical scenarios-though rhinologists did so more often than non-rhinologists. The most frequent barriers to testing related to service provision (e.g., time/funding limitations). Whilst there was variability in practice, in general, international respondents performed psychophysical testing more frequently than those from the UK. Approximately 3/4 of all respondents said they would like to receive training in psychophysical smell testing. Patient reported outcome measures were infrequently used in the UK/internationally. More UK respondents performed diagnostic MRI scanning than international respondents. CONCLUSIONS: To our knowledge, this is the most comprehensive UK-based, and only international survey of clinical practice in the assessment of OD. We present recommendations to improve practice, including increased education and funding for psychophysical smell testing. We hope this will promote accurate and reliable olfactory assessment, as is the accepted standard in other sensory systems.

• MeSH
• čich * fyziologie   MeSH
• hodnocení výsledků péče pacientem MeSH
• lidé MeSH
• poruchy čichu * diagnóza   MeSH
• průřezové studie MeSH
• průzkumy a dotazníky MeSH
• stupeň vzdělání MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Although there is growing evidence of the association between gender and early diagnosis of preclinical Alzheimer's disease, little attention has been given to the enrolment ratio of men and women in clinical trials and data reporting. METHODS: This study aims to analyze gender differences in sociodemographic factors associated with the willingness to participate in clinical trials and undergo specific procedures in the context of an Alzheimer's disease prevention research cohort. 2544 cognitively unimpaired participants from the ALFA parent cohort (age 45-75 years) of the Barcelonaβeta Brain Research Center were contacted through a structured phone call to determine their willingness to participate in Alzheimer's disease clinical trials and undergo trial-related procedures (magnetic resonance imaging, lumbar puncture, positron emission tomography, and cognitive assessment). Sociodemographic data on education, occupational attainment, civil and caregiver status were gathered. Stepwise logistic regression models were performed in order to study the interaction between gender and sociodemographic factors in the willingness to participate in clinical trials and to undergo clinical trial-related procedures. RESULTS: 1,606 out of the 2,544 participants were women (63.1%). Women were significantly younger and had lower educational attainment compared with men. In addition, women were more likely to be caregivers, single and unemployed. Women showed a significantly lower willingness than men to participate in a clinical trial (p = 0.003) and to undergo a lumbar puncture (p < 0.001). Single women were less willing to participate in clinical trials than single men (p = 0.041). Regarding clinical trial-related procedures, women with higher years of education were significantly less willing to undergo a lumbar puncture (p = 0.031). CONCLUSION: We found gender differences regarding the sociodemographic factors that predict the willingness to participate in clinical trials and to undergo clinical trial-related procedures. Our results highlight the urgent need to design recruitment strategies accounting for gender-related factors, particularly those related to marital status and education.

• MeSH
• Alzheimerova nemoc * psychologie   MeSH
• klinické zkoušky jako téma * psychologie   MeSH
• kohortové studie MeSH
• lidé středního věku MeSH
• lidé MeSH
• pohlavní dimorfismus MeSH
• senioři MeSH
• sexuální faktory MeSH
• stupeň vzdělání MeSH
• výběr pacientů MeSH
• zapojení pacienta psychologie   statistika a číselné údaje   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Non-formal adult education and learning (NAE) is widely recognized as enhancing the quality of life and promoting active aging. Despite the empirically demonstrated benefits, older adults rank among one of the populations participating the least in NAE. Although several studies have highlighted the negative effect of aging on involvement in NAE, factors causing long-term changes in participation have not been explored directly. As a result, the significance of microsocial characteristics and their transformation over time has been overlooked. This article explores key microsocial factors leading to non/participation in NAE among adults aged 50 to 69 years along with changes in these factors for the 14-year period of 2006 to 2019. The research was conducted using the Czech Republic's Labor Force Survey dataset (N = 114,345). The results show that all microsocial factors play an essential role in determining participation in NAE, thus a strong relationship between the social origins (cumulative disadvantage) of older adults and their participation was confirmed. In addition, the impact of most factors has proved consistent over time, not strengthening since 2009. One exception was level of education, which showed a rapid increase in participation in NAE in the respondents who identified themselves as low-educated.

• MeSH
• geriatrie * výchova   MeSH
• kvalita života * MeSH
• lidé MeSH
• senioři MeSH
• stárnutí MeSH
• stupeň vzdělání MeSH
• zaměstnanost MeSH
• zapojení do společnosti MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH

BACKGROUND: Persisting cancer-related fatigue impairs health-related quality of life (HRQoL) and social reintegration in patients with Hodgkin's lymphoma (HL). The GHSG HD18 trial established treatment de-escalation for advanced-stage HL guided by positron emission tomography after two cycles (PET-2) as new standard. Here, we investigate the impact of treatment de-escalation on long-term HRQoL, time to recovery from fatigue (TTR-F), and time to return to work (TTR-W). PATIENTS AND METHODS: Patients received European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and life situation questionnaires at baseline, interim, end of treatment, and yearly follow-up. TTR-F was defined as time from the end of chemotherapy until the first fatigue score <30. TTR-W was analyzed in previously working or studying patients and measured from the end of treatment until the first documented work or education. We compared duration of treatment on TTR-F and TTR-W using Cox proportional hazards regression adjusted for confounding variables. RESULTS: HRQoL questionnaires at baseline were available in 1632 (83.9%) of all randomized patients. Overall, higher baseline fatigue and age were significantly associated with longer TTR-F and TTR-W and male sex with shorter TTR-W. Treatment reduction from eight to four chemotherapy cycles led to a significantly shorter TTR-F [hazard ratio (HR) 1.41, P = 0.008] and descriptively shorter TTR-W (HR 1.24, P = 0.084) in PET-2-negative patients. Reduction from six to four cycles led to non-significant but plausible intermediate accelerations. The addition of rituximab caused significantly slower TTR-F (HR 0.70, P = 0.0163) and TTR-W (HR 0.64, P = 0.0017) in PET-2-positive patients. HRQoL at baseline and age were the main determinants of 2-year HRQoL. CONCLUSIONS: Individualized first-line treatment in patients with advanced-stage HL considerably shortens TTR-F and TTR-W in PET-2-negative patients. Our results support the use of response-adapted shortened treatment duration for patients with HL.

• MeSH
• Hodgkinova nemoc * patologie   MeSH
• kvalita života MeSH
• lidé MeSH
• návrat do práce MeSH
• přežívající MeSH
• protokoly antitumorózní kombinované chemoterapie terapeutické užití   MeSH
• únava etiologie   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• kognice MeSH
• lidé MeSH
• metafyzické vztahy mezi duší a tělem MeSH
• náboženství a psychologie MeSH
• sociální změna MeSH
• spiritualita MeSH
• umělá inteligence MeSH
• vědomí * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

The antibiotic resistance genes (ARGs) limit the susceptibility of bacteria to antimicrobials, representing a problem of high importance. Current research on the presence of ARGs in microorganisms focuses mainly on humans, livestock, hospitals, or wastewater. However, the spectrum of ARGs in the dust resistome in workplaces and households has gone relatively unexplored. This pilot study aimed to analyze resistome in indoor dust samples from participants' workplaces (a pediatric hospital, a maternity hospital, and a research center) and households and compare two different approaches to the ARGs analysis; high-throughput quantitative PCR (HT-qPCR) and whole metagenome shotgun sequencing (WMGS). In total, 143 ARGs were detected using HT-qPCR, with ARGs associated with the macrolides, lincosamides, and streptogramin B (MLSB) phenotype being the most abundant, followed by MDR (multi-drug resistance) genes, and genes conferring resistance to aminoglycosides. A higher overall relative quantity of ARGs was observed in indoor dust samples from workplaces than from households, with the pediatric hospital being associated with the highest relative quantity of ARGs. WMGS analysis revealed 36 ARGs, of which five were detected by both HT-qPCR and WMGS techniques. Accordingly, the efficacy of the WMGS approach to detect ARGs was lower than that of HT-qPCR. In summary, our pilot data revealed that indoor dust in buildings where people spend most of their time (workplaces, households) can be a significant source of antimicrobial-resistant microorganisms, which may potentially pose a health risk to both humans and animals.

• MeSH
• antibakteriální látky farmakologie   MeSH
• Bacteria genetika   izolace a purifikace   účinky léků   klasifikace   MeSH
• bakteriální geny genetika   MeSH
• bakteriální léková rezistence genetika   MeSH
• charakteristiky rodiny MeSH
• kvantitativní polymerázová řetězová reakce MeSH
• lidé MeSH
• metagenom MeSH
• mikrobiologie vzduchu MeSH
• pilotní projekty MeSH
• prach * analýza   MeSH
• pracoviště * MeSH
• vysoce účinné nukleotidové sekvenování MeSH
• znečištění vzduchu ve vnitřním prostředí MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Soudní lékař se často setkává s diagnózou otřesu mozku, respektive lehkého mozkového poranění (mTBI). Dřívější koncept mozkové komoce (otřesu mozku) jako funkční a plně reverzibilní klinické jednotky je nutno považovat za překonaný, neboť otřes mozku může vést k prokazatelným strukturálním změnám mozku. Proto se doporučuje od používání pojmu „otřes mozku“ či „komoce“ co nejdříve upustit. Protože jsou ale tyto termíny v klinické praxi mnohde stále používány a neexistuje jednoznačné kritérium, jak odlišit komoci od mTBI, je pragmatické tyto pojmy považovat za synonyma, což platí i pro tento článek. Soudní lékař v souvislosti s mTBI řeší zpravidla tři otázky: diagnóza zranění, závažnost zranění a mechanizmus a způsob vzniku zranění. Měl by vždy zvážit, zda ke klinikem diagnostikovanému mTBI skutečně došlo, k tomu může využít konzultaci s neurologem. Pokud ano, jde vždy o poruchu zdraví, může ale jít i o těžké zranění. Ze statistiky ÚZIS vyplývá, že průměrná doba léčení je u otřesu mozku delší než dosud akceptované 2–3 týdny. Postkomoční syndrom je relativně častou komplikací otřesu mozku. Adresa pro korespondenci: doc. MUDr. František Vorel, CSc., Soudnělékařské oddělení Nemocnice České Budějovice, a.s. B. Němcové 54, 370 01 České Budějovice tel. 602 430 152, e-mail vorel.frantisek@nemcb.cz Delivered: March 1, 2024 Accepted: April 1, 2024

The forensic physician is often faced with the diagnosis of concussion or mild traumatic brain injury (mTBI). The earlier concept of cerebral concussion as a functional and fully reversible clinical entity must be considered obsolete, as concussion can lead to demonstrable structural changes in the brain. It is therefore recommended that the use of the term ‘concussion’ be abandoned as soon as possible. However, as these terms are still used in clinical practice in many places and there is no clear criterion to distinguish concussion from mTBI, it is pragmatic to consider these terms as synonyms. The forensic physician typically addresses three issues in the context of mTBI: the diagnosis of the injury, the severity of the injury, and the mechanism and mode of injury. He or she should always consider whether the clinician-diagnosed mTBI actually occurred, and may use consultation with a neurologist to do so. If so, it is always a medical disorder, but it may also be a severe injury. Statistics from the Institute of Health Information and Statistics (IHIS) show that the average period of incapacity for concussion is 39 days for people aged 20-65, which is longer than the previously accepted 2-3 weeks. The average period of incapacity for work for men and women is not statistically different. However, it increases with age, by almost one day for each year of age between 20 and 65 years. Post-concussion syndrome is a relatively common complication of concussion.

• MeSH
• komoce mozku * diagnóza   etiologie   MeSH
• lidé MeSH
• postkomoční syndrom diagnóza   patologie   MeSH
• pracovní neschopnost statistika a číselné údaje   MeSH
• stupeň závažnosti nemoci MeSH
• traumatické poranění mozku * diagnóza   etiologie   MeSH
• výzkum MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

Publikace obsahuje rozhovor, který se zaměřuje na vztahy mezi matkou a synem a na transgender osoby a otázky identity a tranzice. Určeno široké veřejnosti.

• Klíčová slova
• tranzice,
• MeSH
• dějiny 20. století MeSH
• dějiny 21. století MeSH
• genderová identita MeSH
• matky psychologie   MeSH
• nukleární rodina MeSH
• péče potvrzující pohlaví MeSH
• psychologie MeSH
• transgender osoby * psychologie   MeSH
• výchova dítěte MeSH
• vztahy mezi matkou a dítětem MeSH
• Check Tag
• dějiny 20. století MeSH
• dějiny 21. století MeSH
• Publikační typ
• rozhovory MeSH
• Geografické názvy
• Česká republika MeSH

• Konspekt
• Vývojová psychologie. Individuální psychologie
• NLK Obory
• psychologie, klinická psychologie
• sociologie

• O autorovi
• Suchý, Adam, 1974- Autorita
• Vernerová, Alena Autorita