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The time has come for revising the rules of clozapine blood monitoring in Europe. A joint expert statement from the European Clozapine Task Force
H. Verdoux, RA. Bittner, A. Hasan, M. Qubad, E. Wagner, A. Lepetit, M. Arrojo-Romero, C. Bachmann, M. Beex-Oosterhuis, J. Bogers, A. Celofiga, D. Cohen, D. de Berardis, M. de Hert, C. de Las Cuevas, BH. Ebdrup, KN. Fountoulakis, D. Guinart, D....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 1991
PubMed Central
od 2020
ROAD: Directory of Open Access Scholarly Resources
od 1991
- MeSH
- agranulocytóza * chemicky indukované MeSH
- antipsychotika * terapeutické užití škodlivé účinky MeSH
- klozapin * terapeutické užití škodlivé účinky krev MeSH
- lidé MeSH
- monitorování léčiv * metody normy MeSH
- poradní výbory MeSH
- refrakterní schizofrenie farmakoterapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
The European Clozapine Task Force is a group of psychiatrists and pharmacologists practicing in 18 countries under European Medicines Agency (EMA) regulation, who are deeply concerned about the underuse of clozapine in European countries. Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia, a large proportion of them do not have access to this treatment. Concerns about clozapine-induced agranulocytosis and stringent blood monitoring rules are major barriers to clozapine prescribing and use. There is a growing body of evidence that the incidence of clozapine-induced agranulocytosis is very low after the first year of treatment. Maintaining lifelong monthly blood monitoring after this period contributes to unjustified discontinuation of clozapine. We leverage recent and replicated evidence on the long-term safety of clozapine to call for the revision and updating of the EMA's blood monitoring rules, thus aiming to overcome this major barrier to clozapine prescribing and use. We believe the time has come for relaxing the rules without increasing the risks for people using clozapine in Europe.
ACPPA Group Francheville France
Amsterdam Neuroscience Research Institutes Amsterdam The Netherlands
Antwerp Health Law and Ethics Chair University of Antwerp Antwerp Belgium
Center for Psychopharmacology Diakonhjemmet Hospital Oslo Norway
Centre for Biomedical Network Research on Rare Diseases Instituto de Salud Carlos 3 Madrid Spain
Department of Affective Disorders Aarhus University Hospital Psychiatry Aarhus Denmark
Department of Child and Adolescent Psychiatry Ulm University Ulm Germany
Department of Clinical and Experimental Medicine University of Messina Messina Italy
Department of Clinical Medicine Aarhus University Aarhus Denmark
Department of Forensic Psychiatry University of Eastern Finland Niuvanniemi Hospital Kuopio Finland
Department of Hospital Pharmacy Albert Schweitzer Hospital Dordrecht The Netherlands
Department of Psychiatry 3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Psychiatry Amsterdam UMC Amsterdam The Netherlands
Department of Psychiatry and Psychological Medicine University Hospital Centre Zagreb Zagreb Croatia
Department of Psychiatry Hôpital Universitaire de Bruxelles Bruxelles Belgium
Department of Psychiatry Medical University of Gdańsk Gdańsk Poland
Department of Psychiatry School of Medicine University of Zagreb Zagreb Croatia
Department of Psychiatry St Vincent's Hospital Fairview Dublin Ireland
Department of Psychiatry St Vincent's University Hospital Dublin Ireland
Department of Psychiatry University College Dublin Dublin Ireland
Department of Psychiatry University Medical Centre Maribor Maribor Slovenia
Dutch Clozapine Collaboration Group Alkmaar The Netherlands
DZPG Partner Site Munich Augsburg Germany
Esdege Reigersdaal Heerhugowaard The Netherlands
Faculty of Dental Medicine and Health Josip Juraj Strossmayer University of Osijek Osijek Croatia
Galician Public Foundation of Genomic Medicine Santiago de Compostela Spain
Genomic Medicine Group CIMUS University of Santiago de Compostela Santiago de Compostela Spain
GGZ inGeest Mental Health Care Amsterdam The Netherlands
Hospices Civils de Lyon Hôpital des Charpennes Villeurbanne France
Hospital Universitario de Canarias Tenerife Spain
Institut de Salut Mental Hospital del Mar Barcelona Spain
Institut des Sciences Cognitives Marc Jeannerod CNRS Bron France
Leuven Brain Institute Katholieke Universiteit Leuven Leuven Belgium
Mental Health Centre Glostrup Copenhagen University Hospital Copenhagen Denmark
Mental Health Organization Rivierduinen Leiden The Netherlands
Mental Health Services Noord Holland Noord Alkmaar The Netherlands
Mental Health Services Noord Holland Noord Schagen The Netherlands
National Institute of Mental Health Klecany Czech Republic
Neuroscience Center University of Helsinki Helsinki Finland
NHS Department of Mental Health G Mazzini Hospital Teramo Italy
Nyírő Gyula National Institute of Psychiatry and Addictions Budapest Hungary
Pharmacogenomics and Drug Discovery Santiago de Compostela Spain
Programa Recerca en Salut Mental Hospital del Mar Research Institute CIBERSAM Barcelona Spain
Saint John of God Hospital Stillorgan Co Dublin Dublin Ireland
School of Pharmacy University of Eastern Finland Kuopio Finland
The Donald and Barbara Zucker School of Medicine Northwell Health New York NY USA
University Psychiatric Center Katholieke Universiteit Leuven Kortenberg Belgium
Citace poskytuje Crossref.org
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