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Minimal residual disease detection for acute lymphoblastic leukaemia in peripheral blood-Are we there yet
J. Trka, E. Fronkova
Language English Country England, Great Britain
Document type Journal Article
PubMed
39529365
DOI
10.1111/bjh.19888
Knihovny.cz E-resources
- MeSH
- Precursor Cell Lymphoblastic Leukemia-Lymphoma * blood diagnosis genetics MeSH
- Humans MeSH
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma diagnosis blood genetics MeSH
- Neoplasm, Residual * diagnosis MeSH
- High-Throughput Nucleotide Sequencing * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Can peripheral blood be used to detect residual disease in acute lymphoblastic leukaemia (ALL) when we increase the sensitivity of the method used? Bendig et al. found that a larger amount of material and the use of next-generation sequencing (NGS) detects MRD in peripheral blood in up to half of patients with B-cell precursor ALL (BCP-ALL) where routine examination was negative. However, a negative result does not exclude the presence of residual disease and thus still limits the use of peripheral blood. Commentary on: Bendig et al. Next-generation sequencing and high DNA input identify previously missed measurable residual disease in peripheral blood of B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 2025; 206:353-356.
References provided by Crossref.org
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