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Minimal residual disease detection for acute lymphoblastic leukaemia in peripheral blood-Are we there yet
J. Trka, E. Fronkova
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
PubMed
39529365
DOI
10.1111/bjh.19888
Knihovny.cz E-zdroje
- MeSH
- akutní lymfatická leukemie * krev diagnóza genetika MeSH
- lidé MeSH
- pre-B-buněčná leukemie diagnóza krev genetika MeSH
- reziduální nádor * diagnóza MeSH
- vysoce účinné nukleotidové sekvenování * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Can peripheral blood be used to detect residual disease in acute lymphoblastic leukaemia (ALL) when we increase the sensitivity of the method used? Bendig et al. found that a larger amount of material and the use of next-generation sequencing (NGS) detects MRD in peripheral blood in up to half of patients with B-cell precursor ALL (BCP-ALL) where routine examination was negative. However, a negative result does not exclude the presence of residual disease and thus still limits the use of peripheral blood. Commentary on: Bendig et al. Next-generation sequencing and high DNA input identify previously missed measurable residual disease in peripheral blood of B-cell precursor acute lymphoblastic leukaemia. Br J Haematol 2025; 206:353-356.
Citace poskytuje Crossref.org
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