Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Correlation between glucocorticoid receptor gene variation and responsivity in patients with chronic bronchitis taking oral prednisolone

Mohammed T. Yaseen, Dalia B. Hanna, Ali M. Hadi

. 2025 ; 94 (2) : 48-57. [pub] 20250602

Language English Country Czech Republic

Document type Clinical Study, Research Support, Non-U.S. Gov't

Chronic bronchitis is increasingly reported as a healthcare challenge in clinical settings partially due to the disease's bad prognosis and unresponsiveness to therapy, including the ineffectiveness of glucocorticoids. The ineffectiveness could have a link with genetic polymorphism of receptor genes resulting in inappropriate glucocorticoid pharmacodynamics. We sought to identify the role of gene polymorphism in the response of patients with chronic bronchitis to prednisolone therapy. To do so, a total of 60 newly diagnosed chronic bronchitis patients enrolled in the present study. Prednisolone at a dose of 30mg/day for two weeks was given and respiratory parameters [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC were measured before and after therapy. Blood samples were withdrawn for genetic profiling of genes involved in glucocorticoids pharmacodynamics, including BCII (rs41423247), N363S (rs56149945), and ER22/23EK (rs6189/rs6190) measured for their homozygous versus heterozygous gene splice variants.Results: Gene splice variants for BCII (rs41423247), N363S (rs56149945), and ER22/23EK (rs6189/rs6190) homozygous (73.3%, 98.7%, and 95%) represented a higher percentage than heterozygous (26.7%, 1.7%, and 5%). The respiratory parameters FEV1, FVC, and FEV1/FVC have shown significantly (p<0.05) better values at baseline in homozygous versus heterozygous, correspondingly, the responsiveness to therapy has shown significantly (p<0.05) better values in homozygous versus heterozygous.Conclusion: The study has provided a good template for genetic behaviour toward individualised medicine in our locality providing that these genes could be a cornerstone for discovering issues related to the pharmacodynamics profiling of drugs in clinical settings.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25013056
003      
CZ-PrNML
005      
20250723204456.0
007      
ta
008      
250710s2025 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.31482/mmsl.2024.004 $2 doi
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Yaseen, Mohammed T. $u College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq
245    10
$a Correlation between glucocorticoid receptor gene variation and responsivity in patients with chronic bronchitis taking oral prednisolone / $c Mohammed T. Yaseen, Dalia B. Hanna, Ali M. Hadi
520    3_
$a Chronic bronchitis is increasingly reported as a healthcare challenge in clinical settings partially due to the disease's bad prognosis and unresponsiveness to therapy, including the ineffectiveness of glucocorticoids. The ineffectiveness could have a link with genetic polymorphism of receptor genes resulting in inappropriate glucocorticoid pharmacodynamics. We sought to identify the role of gene polymorphism in the response of patients with chronic bronchitis to prednisolone therapy. To do so, a total of 60 newly diagnosed chronic bronchitis patients enrolled in the present study. Prednisolone at a dose of 30mg/day for two weeks was given and respiratory parameters [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC were measured before and after therapy. Blood samples were withdrawn for genetic profiling of genes involved in glucocorticoids pharmacodynamics, including BCII (rs41423247), N363S (rs56149945), and ER22/23EK (rs6189/rs6190) measured for their homozygous versus heterozygous gene splice variants.Results: Gene splice variants for BCII (rs41423247), N363S (rs56149945), and ER22/23EK (rs6189/rs6190) homozygous (73.3%, 98.7%, and 95%) represented a higher percentage than heterozygous (26.7%, 1.7%, and 5%). The respiratory parameters FEV1, FVC, and FEV1/FVC have shown significantly (p&lt;0.05) better values at baseline in homozygous versus heterozygous, correspondingly, the responsiveness to therapy has shown significantly (p&lt;0.05) better values in homozygous versus heterozygous.Conclusion: The study has provided a good template for genetic behaviour toward individualised medicine in our locality providing that these genes could be a cornerstone for discovering issues related to the pharmacodynamics profiling of drugs in clinical settings.
650    17
$a receptory glukokortikoidů $x genetika $x účinky léků $7 D011965 $2 czmesh
650    17
$a chronická bronchitida $x diagnóza $x genetika $7 D029481 $2 czmesh
650    07
$a glukokortikoidy $x farmakologie $7 D005938 $2 czmesh
650    07
$a prednisolon $x farmakologie $x terapeutické užití $7 D011239 $2 czmesh
650    07
$a polymerázová řetězová reakce $x metody $7 D016133 $2 czmesh
650    07
$a polymorfismus genetický $x genetika $7 D011110 $2 czmesh
650    07
$a protein - isoformy $x genetika $7 D020033 $2 czmesh
650    07
$a respirační funkční testy $x metody $7 D012129 $2 czmesh
650    07
$a lidé $7 D006801 $2 czmesh
655    _7
$a klinická studie $7 D000068397 $2 czmesh
655    _7
$a práce podpořená grantem $7 D013485 $2 czmesh
700    1_
$a Hanna, Dalia B. $u College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq
700    1_
$a Hadi, Ali M. $u College of Pharmacy, University of Basrah, Basrah, Iraq
773    0_
$t Vojenské zdravotnické listy $x 0372-7025 $g Roč. 94, č. 2 (2025), s. 48-57 $w MED00011116
856    41
$u https://mmsl.cz/artkey/mms-202502-0001_correlation-between-glucocorticoid-receptor-gene-variation-and-responsivity-in-patients-with-chronic-bronchitis.php $y plný text volně přístupný
910    __
$a ABA008 $b A 3 $c 1073 $y p $z 0
990    __
$a 20250605 $b ABA008
991    __
$a 20250723204446 $b ABA008
999    __
$a ok $b bmc $g 2358574 $s 1250166
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2025 $b 94 $c 2 $d 48-57 $e 20250602 $i 0372-7025 $m Vojenské zdravotnické listy $x MED00011116
LZP    __
$c NLK193 $d 20250723 $b NLK111 $a Actavia-MED00011116-20250605

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...