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An update on diagnosis and treatments of childhood interstitial lung diseases

H. Marczak, K. Krenke, M. Griese, J. Carlens, E. Seidl, C. Gilbert, N. Emiralioglu, A. Torrent-Vernetta, B. Willemse, R. Epaud, C. Delestrain, C. Louvrier, V. Koucký, N. Nathan, ERS CRC chILD-EU group

. 2025 ; 21 (2) : 250004. [pub] 20250513

Status not-indexed Language English Country England, Great Britain

Document type Journal Article, Review

Childhood interstitial lung diseases (chILDs) are rare and heterogeneous disorders associated with significant morbidity and mortality. The clinical presentation of chILD typically includes chronic or recurrent respiratory signs and symptoms with diffuse radiographic abnormalities on chest imaging. Diagnosis requires a structured, multi-step approach. Treatment options are limited, with disease-specific therapies available only in selected cases and management relying primarily on supportive care. Awareness of chILDs has been steadily increasing. New diagnoses, advanced diagnostic tests, and novel treatments are emerging each year, highlighting the importance of collaborative, multidisciplinary teams in providing comprehensive care for children and families affected by these complex conditions. On behalf of the European Respiratory Society Clinical Research Collaboration for chILD (ERS CRC chILD-EU), this review provides an updated overview of the diagnostic approach and management strategies for chILDs.

Centre Hospitalier Intercommunal de Créteil Service de Pédiatrie Générale Centre de référence des maladies respiratoires rares Créteil France

Centro de Investigación Biomédica en Red de Enfermedades Raras Madrid Spain

Clinic for Pediatric Pneumology Hannover Medical School Hannover Germany

Department of Molecular Genetics Armand Trousseau Hospital Assistance Publique Hôpitaux de Paris Paris France

Department of Paediatric Pneumology Dr von Hauner Children's Hospital German Centre for Lung Research University of Munich Munich Germany

Department of Paediatrics 2nd Faculty of Medicine Charles University and University Hospital Motol Prague Czech Republic

Department of Pediatric Pneumology and Allergy Medical University of Warsaw Warsaw Poland

Department of Pediatric Pulmonology and Pediatric Allergology Beatrix Children's Hospital University of Groningen University Medical Center Groningen Groningen The Netherlands

Department of Pediatric Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey

Division of Respiratory Medicine University Children's Hospital Zurich Zurich Switzerland

Institute of Population Health University of Liverpool Liverpool UK

Laboratory of Childhood Genetic Diseases Inserm UMR_S933 Sorbonne University Armand Trousseau Hospital Paris France

Pediatric Allergy and Pulmonology Section Department of Pediatrics Vall d'Hebron Hospital Universitari Vall d'Hebron Barcelona Hospital Campus Universitat Autònoma de Barcelona Barcelona Spain

Pediatric Pulmonology Department and Reference centre for rare lung diseases RespiRare Armand Trousseau Hospital Assistance Publique Hôpitaux de Paris Paris France

University Paris Est Créteil INSERM IMRB Créteil France

References provided by Crossref.org

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$a Childhood interstitial lung diseases (chILDs) are rare and heterogeneous disorders associated with significant morbidity and mortality. The clinical presentation of chILD typically includes chronic or recurrent respiratory signs and symptoms with diffuse radiographic abnormalities on chest imaging. Diagnosis requires a structured, multi-step approach. Treatment options are limited, with disease-specific therapies available only in selected cases and management relying primarily on supportive care. Awareness of chILDs has been steadily increasing. New diagnoses, advanced diagnostic tests, and novel treatments are emerging each year, highlighting the importance of collaborative, multidisciplinary teams in providing comprehensive care for children and families affected by these complex conditions. On behalf of the European Respiratory Society Clinical Research Collaboration for chILD (ERS CRC chILD-EU), this review provides an updated overview of the diagnostic approach and management strategies for chILDs.
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