Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer

AP. Goncharov, C. Dicusari Elissaiou, E. Ben Aharon Farzalla, G. Akhvlediani, N. Vashakidze, G. Kharaishvili

. 2025 ; 57 (1) : 2474175. [pub] 20250515

Language English Country England, Great Britain

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc25015080

From tumorigenesis to the establishment of local or metastatic high-grade tumours, an integral part of the cellular lifespan relies on various signalling pathways. Particular pathways that allow cells to proliferate by creating a network of new blood vessels have been documented, whereas other pathways are primarily involved with a migration to distant body parts, partially through the process of epithelial-mesenchymal transition (EMT). This review will discuss the different signalling pathways, such as TGF-β, Cripto-1, Wnt pathways, Hedgehog, Notch and NF-κB pathways, and how they promote tumour initiation and progression by influencing diverse cellular processes and EMT in general and in benign and malignant prostate tumours. This review will discuss only the critical pathways. Therefore, many other types of signalling pathways which are related to prostate cancer will not be discussed. Possibilities for further investigation will be mentioned, as many underlying mechanisms involved in these pathways have potential as targets in future tumour therapy. This review will also introduce some novel clinical trials relating to the inhibition of signalling pathways and their clinical outcomes.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25015080
003      
CZ-PrNML
005      
20250731090742.0
007      
ta
008      
250708s2025 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1080/07853890.2025.2474175 $2 doi
035    __
$a (PubMed)40372974
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Goncharov, Aviv Philip $u Department of Clinical and Molecular Pathology, Palacky University, Olomouc, Czech Republic $u Department of Oncology, University Hospital, Olomouc, Czech Republic $1 https://orcid.org/0009000118113535
245    10
$a Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer / $c AP. Goncharov, C. Dicusari Elissaiou, E. Ben Aharon Farzalla, G. Akhvlediani, N. Vashakidze, G. Kharaishvili
520    9_
$a From tumorigenesis to the establishment of local or metastatic high-grade tumours, an integral part of the cellular lifespan relies on various signalling pathways. Particular pathways that allow cells to proliferate by creating a network of new blood vessels have been documented, whereas other pathways are primarily involved with a migration to distant body parts, partially through the process of epithelial-mesenchymal transition (EMT). This review will discuss the different signalling pathways, such as TGF-β, Cripto-1, Wnt pathways, Hedgehog, Notch and NF-κB pathways, and how they promote tumour initiation and progression by influencing diverse cellular processes and EMT in general and in benign and malignant prostate tumours. This review will discuss only the critical pathways. Therefore, many other types of signalling pathways which are related to prostate cancer will not be discussed. Possibilities for further investigation will be mentioned, as many underlying mechanisms involved in these pathways have potential as targets in future tumour therapy. This review will also introduce some novel clinical trials relating to the inhibition of signalling pathways and their clinical outcomes.
650    _2
$a lidé $7 D006801
650    12
$a nádory prostaty $x patologie $x metabolismus $x terapie $x farmakoterapie $7 D011471
650    _2
$a mužské pohlaví $7 D008297
650    12
$a signální transdukce $x fyziologie $7 D015398
650    _2
$a epitelo-mezenchymální tranzice $x fyziologie $7 D058750
650    _2
$a transformující růstový faktor beta $x metabolismus $7 D016212
650    _2
$a proteiny hedgehog $x metabolismus $7 D053823
650    _2
$a NF-kappa B $x metabolismus $7 D016328
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Dicusari Elissaiou, Constantinos $u Department of Clinical and Molecular Pathology, Palacky University, Olomouc, Czech Republic
700    1_
$a Ben Aharon Farzalla, Elad $u Department of Clinical and Molecular Pathology, Palacky University, Olomouc, Czech Republic
700    1_
$a Akhvlediani, Giorgi $u Faculty of Medicine, Georgian-American University, Tbilisi, Georgia $u American Hospital in Tbilisi, Tbilisi, Georgia $u Faculty of Medicine, University of Georgia, Tbilisi, Georgia
700    1_
$a Vashakidze, Nino $u Department of Clinical and Molecular Pathology, Palacky University, Olomouc, Czech Republic
700    1_
$a Kharaishvili, Gvantsa $u Department of Human Morphology and Pathology, Medical Faculty, David Tvildiani Medical University, Tbilisi, Georgia $u Department of Clinical and Molecular Pathology, University Hospital, Olomouc, Czech Republic $1 https://orcid.org/0000000336186145
773    0_
$w MED00009195 $t Annals of medicine $x 1365-2060 $g Roč. 57, č. 1 (2025), s. 2474175
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40372974 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250708 $b ABA008
991    __
$a 20250731090736 $b ABA008
999    __
$a ok $b bmc $g 2366146 $s 1252205
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 57 $c 1 $d 2474175 $e 20250515 $i 1365-2060 $m Annals of medicine $n Ann Med $x MED00009195
LZP    __
$a Pubmed-20250708

Find record

Citation metrics

Archiving options