55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. They are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. T4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.

Annotation

for hematodermic CD4/CD56 neoplasm use LYMPHOMA, NON-HODGKIN

DUI

D015704 MeSH Browser

CUI

M0024088

Previous indexing

Antigens, Differentiation, T-Lymphocyte (1988-1989); Antigens, Surface (1979-1987); Receptors, Antigen, T-Cell (1980-1989); Receptors, Virus (1979-1989)

History note

2018 (1989); use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1989

Public note

2018; see ANTIGENS, CD4 1990-2017 and ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1989