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Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer
S. Selvi, CM. Real, M. Gentiluomo, K. Balounova, K. Vokacova, A. Cumova, B. Mohlenikova-Duchonova, C. Rizzato, E. Halasova, L. Vodickova, B. Smolkova, K. Hemminki, D. Campa, P. Vodicka
Language English Country England, Great Britain
Document type Journal Article, Review
- MeSH
- Carcinoma, Pancreatic Ductal * genetics pathology MeSH
- Epigenesis, Genetic MeSH
- Telomere Homeostasis * genetics MeSH
- Humans MeSH
- Pancreatic Neoplasms * genetics pathology MeSH
- Genomic Instability * MeSH
- DNA Repair MeSH
- DNA Damage * MeSH
- Telomere * genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent genomic instability in cancer cells. The latter comprises a) DNA damage response and DNA repair mechanisms, b) DNA replication and mitosis, c) epigenetic regulation, and d) telomere maintenance. In our review we addressed the above aspects in relation to the most abundant and severe form of PC, pancreatic ductal adenocarcinoma (PDAC). In summary, the interactions between the DNA damage response, telomere homeostasis and mitotic regulation are not comprehensively understood at present, including the epigenetic factors entering the trait of genomic stability maintenance. In addition, the complexity of telomere homeostasis in relation to PDAC risk, prognosis and prediction also warrants further investigations.
Department of Biology University of Pisa Pisa 56123 Italy
Department of Oncology Olomouc University Hospital Zdravotniku 248 7 Olomouc 77900 Czech Republic
Department of Physiology Faculty of Science Charles University Prague Czech Republic
Division of Cancer Epidemiology German Cancer Research Center Heidelberg FRG 69120 Germany
References provided by Crossref.org
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- $a Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent genomic instability in cancer cells. The latter comprises a) DNA damage response and DNA repair mechanisms, b) DNA replication and mitosis, c) epigenetic regulation, and d) telomere maintenance. In our review we addressed the above aspects in relation to the most abundant and severe form of PC, pancreatic ductal adenocarcinoma (PDAC). In summary, the interactions between the DNA damage response, telomere homeostasis and mitotic regulation are not comprehensively understood at present, including the epigenetic factors entering the trait of genomic stability maintenance. In addition, the complexity of telomere homeostasis in relation to PDAC risk, prognosis and prediction also warrants further investigations.
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