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Integrator complex collapse: A mechanistic route to integrated stress response and disease
B. Valtorta, H. Hanzlikova
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc25015284
- MeSH
- dvouvláknová RNA metabolismus genetika MeSH
- fyziologický stres * MeSH
- lidé MeSH
- neurovývojové poruchy * genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
In a recent Cell article, Baluapuri et al.1 show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
Faculty of Science Charles University Prague Prague 2 128 43 Czech Republic
Institute of Animal Pathology Vetsuisse Faculty University of Bern 3012 Bern Switzerland
Citace poskytuje Crossref.org
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- $a Valtorta, Beatrice $u Laboratory of Genome Dynamics, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague 4 142 20, Czech Republic; Faculty of Science, Charles University in Prague, Prague 2 128 43, Czech Republic
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- $a In a recent Cell article, Baluapuri et al.1 show that loss of the Integrator (INT) complex activates the integrated stress response via double-stranded RNA from incomplete pre-mRNAs, revealing a link to INT-related neurodevelopmental diseases and potential therapeutic targets.
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