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X-chromosome-wide association study for Alzheimer's disease
J. Le Borgne, L. Gomez, S. Heikkinen, N. Amin, S. Ahmad, SH. Choi, J. Bis, B. Grenier-Boley, OG. Rodriguez, L. Kleineidam, J. Young, KP. Tripathi, L. Wang, A. Varma, R. Campos-Martin, S. van der Lee, V. Damotte, I. de Rojas, S. Palmal, EADB,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
RC2 AG036528
NIA NIH HHS - United States
U24 AG021886
NIA NIH HHS - United States
U24 AG072122
NIA NIH HHS - United States
U01 AG032984
NIA NIH HHS - United States
P30 AG066508
NIA NIH HHS - United States
U24 AG041689
NIA NIH HHS - United States
P30 AG072977
NIA NIH HHS - United States
- MeSH
- Alzheimerova nemoc * genetika MeSH
- celogenomová asociační studie metody MeSH
- genetická predispozice k nemoci genetika MeSH
- inaktivace chromozomu X genetika MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé MeSH
- lidské chromozomy X * genetika MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10-8) but identified seven X-chromosome-wide significant loci (P ≤ 1.6 × 10-6). The index variants were common for the Xp22.32, FRMPD4, DMD and Xq25 loci, and rare for the WNK3, PJA1, and DACH2 loci. Overall, this well-powered XWAS found no genetic risk factors for AD on the non-pseudoautosomal region of the X-chromosome, but it identified suggestive signals warranting further investigations.
Alzheimer Research Center and Memory Clinic Andalusian Institute for Neuroscience Málaga Spain
Alzheimer's Centre Reina Sofia CIEN Foundation ISCIII Madrid Spain
Arizona Alzheimer's Consortium Phoenix AZ USA
Banner Alzheimer's Institute Phoenix AZ USA
Boston University and the NHLBI's Framingham Heart Study Boston MA USA
Centro de Biología Molecular Severo Ochoa Madrid Spain
CHU de Bordeaux Pole Santé Publique Bordeaux France
Cleveland Clinic Lou Ruvo Center for Brain Health Cleveland Clinic Cleveland OH USA
Clinic of Neurology UH Alexandrovska Medical University Sofia Sofia Bulgaria
Complex Genetics of Alzheimer's Disease Group VIB Center for Molecular Neurology VIB Antwerp Belgium
Department of Biomedical Sciences University of Antwerp Antwerp Belgium
Department of Biomedical Surgical and Dental Sciences University of Milan Milan Italy
Department of Biostatistics Boston University Boston MA USA
Department of Biostatistics Boston University School of Public Health Boston MA USA
Department of Clinical and Experimental Sciences University of Brescia Brescia Italy
Department of Clinical Biochemistry Copenhagen University Hospital Rigshospitalet Copenhagen Denmark
Department of Clinical Genetics VU University Medical Centre Amsterdam The Netherlands
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Clinical Sciences and Community Health University of Milan 20122 Milan Italy
Department of Epidemiology and Biostatistics Case Western Reserve University Cleveland OH USA
Department of Epidemiology and Population Health Stanford University Stanford CA USA
Department of Epidemiology Boston University Boston MA USA
Department of Epidemiology Erasmus MC Rotterdam The Netherlands
Department of Epidemiology University of Washington Seattle WA USA
Department of Geriatric Psychiatry University Hospital of Psychiatry Zürich Zürich Switzerland
Department of Hematology and Stem Cell Transplant Vito Fazzi Hospital Lecce Italy
Department of Human Genetics University of Pittsburgh Pittsburgh PA USA
Department of Medical and Molecular Genetics Indiana University Indianapolis IN USA
Department of Medicine and Surgery Unit of Neurology University Hospital of Parma Parma Italy
Department of Medicine Boston University Boston MA USA
Department of Medicine Cardiovascular Health Research Unit University of Washington Seattle WA USA
Department of Medicine University of Washington Seattle WA USA
Department of Medicine University of Wisconsin Madison WI USA
Department of Neurobiology and Behavior University of California Irvine Irvine CA USA
Department of Neurological Sciences Rush University Medical Center Chicago IL USA
Department of Neurology Albert Einstein College of Medicine New York NY USA
Department of Neurology and Neurological Sciences Stanford University Stanford CA USA
Department of Neurology Bordeaux University Hospital Bordeaux France
Department of Neurology Boston University Boston MA USA
Department of Neurology Boston University School of Medicine Boston MA USA
Department of Neurology Columbia University New York NY USA
Department of Neurology Emory University Atlanta GA USA
Department of Neurology Erasmus MC Rotterdam The Netherlands
Department of Neurology Hospital Universitario Donostia San Sebastian Spain
Department of Neurology Johns Hopkins University Baltimore MD USA
Department of Neurology Massachusetts General Hospital Harvard Medical School Boston MA USA
Department of Neurology Mayo Clinic Rochester MN USA
Department of Neurology Northwestern University Feinberg School of Medicine Chicago IL USA
Department of Neurology University of Alabama at Birmingham Birmingham AL USA
Department of Neurology University of California Davis Sacramento CA USA
Department of Neurology University of Southern California Los Angeles CA USA
Department of Neurology University of Washington Seattle WA USA
Department of Neurology Washington University St Louis MO USA
Department of Neuroscience Mayo Clinic Jacksonville FL USA
Department of Neuroscience Mount Sinai School of Medicine New York NY USA
Department of Neuroscience Rita Levi Montalcini University of Torino Torino Italy
Department of Neuroscience Università Cattolica del Sacro Cuore Rome Italy
Department of Neurosciences University of California San Diego La Jolla CA USA
Department of Ophthalmology Boston University Boston MA USA
Department of Pathology and Immunology Washington University St Louis MO USA
Department of Pathology Boston University Boston MA USA
Department of Pathology Rush University Medical Center Chicago IL USA
Department of Psychiatry and Psychotherapy University Medical Center Goettingen Goettingen Germany
Department of Psychiatry Mount Sinai School of Medicine New York NY USA
Department of Psychiatry New York University New York NY USA
Department of Psychiatry University of Arizona Phoenix AZ USA
Department of Public Health and Caring Sciences Geriatrics Uppsala University Uppsala Sweden
Department of Public Health Sciences University of Miami Miller School of Medicine Miami FL USA
Department of Radiology Indiana University Indianapolis IN USA
Department of Radiology University of Washington Seattle WA USA
Dr John T Macdonald Foundation Department of Human Genetics University of Miami Miami FL USA
Estudios en Neurociencias y Sistemas Complejos CONICET HEC UNAJ Buenos Aires Argentina
Faculty of Medicine University of Lisbon Lisbon Portugal
Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy
Fundació Docència i Recerca MútuaTerrassa Terrassa Barcelona Spain
Geriatric Research Education and Clinical Center University of Wisconsin Madison WI USA
Geriatric Unit Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico 20122 Milan Italy
German Center for Neurodegenerative Diseases Berlin Germany
German Center for Neurodegenerative Diseases Bonn Germany
German Center for Neurodegenerative Diseases Goettingen Germany
German Center for Neurodegenerative Diseases Magdeburg Germany
German Center for Neurodegenerative Diseases Munich Germany
Gertrude H Sergievsky Center Columbia University New York NY USA
Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases San Antonio TX USA
Institut de Recerca Biomedica de Lleida Lleida Spain
Institute for Regenerative Medicine University of Zürich Zurich Switzerland
Institute for Stroke and Dementia Research University Hospital LMU Munich Munich Germany
Institute for Urban Public Health University Hospital of University Duisburg Essen Essen Germany
Institute of Biomedicine University of Eastern Finland Kuopio Finland
Institute of Clinical Medicine Neurology University of Eastern Finland Kuopio Finland
Institute of Clinical Medicine University of Oslo Oslo Norway
Institute of Neurology Catholic University of the Sacred Heart Rome Italy
Instituto de Investigacion Sanitaria 'Hospital la Paz' Madrid Spain
Instituto de Investigación Sanitaria del Principado de Asturias Oviedo Spain
IRCCS Fondazione Don Carlo Gnocchi Florence Italy
Klinik für Psychiatrie und Psychotherapie Saarbrücken Germany
Krembil Brain Institute University Health Network Toronto ON Canada
Laboratorio de Genética Hospital Universitario Central de Asturias Oviedo Spain
Laboratory of Experimental Neuropsychobiology IRCCS Santa Lucia Foundation Rome Italy
Medical Science Department iBiMED Aveiro Portugal
Michigan Alzheimer's Disease Center Department of Neurology University of Michigan Ann Arbor MI USA
Munich Cluster for Systems Neurology Munich Germany
Neurodegenerative Diseases Unit Fondazione IRCCS Ca' Granda Ospedale Policlinico Milan Italy
Neurogenomics Division Translational Genomics Research Institute Phoenix AZ USA
Neurological Tissue Bank Biobank Hospital Clinic FRCB IDIBAPS Barcelona Spain
Neurology Service Marqués de Valdecilla University Hospital Santander Spain
Neurology Unit IRCCS Fondazione Policlinico Universitario A Gemelli Rome Italy
Neurology Unit San Gerardo Hospital Monza and University of Milano Bicocca Milan Italy
Neuroscience Center Zurich University of Zurich and ETH Zurich Zurich Switzerland
Neurosciences Area Instituto Biodonostia San Sebastian Spain
NORMENT Centre Division of Mental Health and Addiction Oslo University Hospital Oslo Norway
Nuffield Department of Population Health Oxford University Oxford UK
Old Age Psychiatry Department of Psychiatry Lausanne University Hospital Lausanne Switzerland
Program in Cellular Neuroscience Neurodegeneration and Repair Yale University New Haven CT USA
Program in Medical and Population Genetics Broad Institute Cambridge MA USA
Rush Alzheimer's Disease Center Rush University Medical Center Chicago IL USA
The John P Hussman Institute for Human Genomics University of Miami Miami FL USA
Translational Health Sciences Bristol Medical School University of Bristol Bristol UK
UK Dementia Research Institute Cardiff University Cardiff UK
Unidad Mixta de Neurologia Genètica Instituto de Investigación Sanitaria La Fe Valencia Spain
Unitat de Genètica Molecular Institut de Biomedicina de València CSIC Valencia Spain
Unitat Trastorns Cognitius Hospital Universitari Santa Maria de Lleida Lleida Spain
Univ Lille Inserm 1171 CHU Clinical and Research Memory Research Centre of Distalz Lille France
Universidad Autónoma de Madrid Madrid Spain
Université de Paris EA 4468 APHP Hôpital Broca Paris France
Université Paris Saclay CEA Centre National de Recherche en Génomique Humaine 91057 Evry France
University Bordeaux Inserm Bordeaux Population Health Research Center Bordeaux France
University of Miami Miller School of Medicine Miami FL USA
University of Pittsburgh Alzheimer's Disease Research Center Pittsburgh PA USA
Wisconsin Alzheimer's Disease Research Center Madison WI USA
Zurich Center for Integrative Human Physiology University of Zurich Zurich Switzerland
Citace poskytuje Crossref.org
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- 520 9_
- $a Due to methodological reasons, the X-chromosome has not been featured in the major genome-wide association studies on Alzheimer's Disease (AD). To address this and better characterize the genetic landscape of AD, we performed an in-depth X-Chromosome-Wide Association Study (XWAS) in 115,841 AD cases or AD proxy cases, including 52,214 clinically-diagnosed AD cases, and 613,671 controls. We considered three approaches to account for the different X-chromosome inactivation (XCI) states in females, i.e. random XCI, skewed XCI, and escape XCI. We did not detect any genome-wide significant signals (P ≤ 5 × 10-8) but identified seven X-chromosome-wide significant loci (P ≤ 1.6 × 10-6). The index variants were common for the Xp22.32, FRMPD4, DMD and Xq25 loci, and rare for the WNK3, PJA1, and DACH2 loci. Overall, this well-powered XWAS found no genetic risk factors for AD on the non-pseudoautosomal region of the X-chromosome, but it identified suggestive signals warranting further investigations.
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Schneider, Anja $u German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany $u Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany $1 https://orcid.org/0000000195408700
- 700 1_
- $a Dichgans, Martin $u Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany $u German Center for Neurodegenerative Diseases (DZNE), Munich, Germany $u Munich Cluster for Systems Neurology (SyNergy), Munich, Germany $1 https://orcid.org/000000020654387X
- 700 1_
- $a Rujescu, Dan $u Martin-Luther-University Halle-Wittenberg, University Clinic and Outpatient Clinic for Psychiatry, Psychotherapy and Psychosomatics, Halle (Saale), Germany $1 https://orcid.org/000000021432313X
- 700 1_
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- 700 1_
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- 700 1_
- $a Riedel-Heller, Steffi $u Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, 04103, Leipzig, Germany $1 https://orcid.org/0000000343216090
- 700 1_
- $a Hausner, Lucrezia $u Department of Geriatric Psychiatry, Central Institute for Mental Health Mannheim, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany $1 https://orcid.org/0000000190092356
- 700 1_
- $a Molina-Porcel, Laura $u Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic of Barcelona, Fundació Recerca Clinic Barcelona- Institut d'Investigacions Biomèdiques August Pi i Sunyer (FRCB-IDIBAPS), and University of Barcelona, Barcelona, Spain $u Neurological Tissue Bank-Biobank, Hospital Clinic-FRCB-IDIBAPS, Barcelona, Spain $1 https://orcid.org/0000000340688578
- 700 1_
- $a Düzel, Emrah $u German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany $u Institute of Cognitive Neurology and Dementia Research (IKND), Otto-von-Guericke University, Magdeburg, Germany
- 700 1_
- $a Grimmer, Timo $u Center for Cognitive Disorders, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine and Health, Klinikum rechts der Isar, Munich, Germany
- 700 1_
- $a Wiltfang, Jens $u Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany $u German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany $u Medical Science Department, iBiMED, Aveiro, Portugal $1 https://orcid.org/0000000314925330
- 700 1_
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- 700 1_
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- 700 1_
- $a Tegos, Thomas $u 1st Department of Neurology, Medical school, Aristotle University of Thessaloniki, Thessaloniki, Makedonia, Greece
- 700 1_
- $a Scarmeas, Nikolaos $u Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Depatment of Neurology, Columbia University, New York, NY, USA $u 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Sánchez-Valle, Raquel $u Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
- 700 1_
- $a Álvarez, Victoria $u Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain $u Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain $1 https://orcid.org/0000000219162523
- 700 1_
- $a Boada, Mercè $u Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/0000000326173009
- 700 1_
- $a García-González, Pablo $u Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain $1 https://orcid.org/0000000301255403
- 700 1_
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- 700 1_
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- 700 1_
- $a Real, Luis M $u Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain $u Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain $1 https://orcid.org/0000000349327429
- 700 1_
- $a Piñol-Ripoll, Gerard $u Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain $u Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain
- 700 1_
- $a García-Alberca, Jose María $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain $1 https://orcid.org/0000000329516644
- 700 1_
- $a Royo, Jose Luís $u Depatamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain
- 700 1_
- $a Rodriguez-Rodriguez, Eloy $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain $1 https://orcid.org/000000017742677X
- 700 1_
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- 700 1_
- $a de Mendonça, Alexandre $u Faculty of Medicine, University of Lisbon, Lisbon, Portugal
- 700 1_
- $a Mehrabian, Shima $u Clinic of Neurology, UH "Alexandrovska", Medical University-Sofia, Sofia, Bulgaria
- 700 1_
- $a Traykov, Latchezar $u Clinic of Neurology, UH "Alexandrovska", Medical University-Sofia, Sofia, Bulgaria
- 700 1_
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- 700 1_
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- 700 1_
- $a Thomassen, Jesper Qvist $u Department of Clinical Biochemistry, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark $1 https://orcid.org/0000000334849531
- 700 1_
- $a Pijnenburg, Yolande A L $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
- 700 1_
- $a Holstege, Henne $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands $u Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands $1 https://orcid.org/0000000276883087
- 700 1_
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- 700 1_
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- 700 1_
- $a Verhey, Frans $u Maastricht University, Department of Psychiatry & Neuropsychologie, Alzheimer Center Limburg, Maastricht, The Netherlands
- 700 1_
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- 700 1_
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- 700 1_
- $a Papenberg, Goran $u Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden
- 700 1_
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- 700 1_
- $a Boland, Anne $u Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France $1 https://orcid.org/0000000187895676
- 700 1_
- $a Deleuze, Jean-François $u Université Paris-Saclay, CEA, Centre National de Recherche en Génomique Humaine, 91057, Evry, France
- 700 1_
- $a Nicolas, Gael $u Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Department of Genetics and CNRMAJ, F-76000, Rouen, France $1 https://orcid.org/0000000193917800
- 700 1_
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- 700 1_
- $a Pasquier, Florence $u Univ. Lille, Inserm 1171, CHU Clinical and Research Memory Research Centre (CMRR) of Distalz, Lille, France $1 https://orcid.org/0000000198809788
- 700 1_
- $a Hanon, Olivier $u Université de Paris, EA 4468, APHP, Hôpital Broca, Paris, France
- 700 1_
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- 700 1_
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- 700 1_
- $a Popp, Julius $u Old Age Psychiatry, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland $u Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, Zürich, Switzerland $u Institute for Regenerative Medicine, University of Zürich, Zurich, Switzerland
- 700 1_
- $a Ghidoni, Roberta $u Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, 25125, Italy $1 https://orcid.org/0000000276911957
- 700 1_
- $a Galimberti, Daniela $u Neurodegenerative Diseases Unit, Fondazione IRCCS Ca' Granda, Ospedale Policlinico, Milan, Italy $u Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy $1 https://orcid.org/0000000292845953
- 700 1_
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- 700 1_
- $a Mecocci, Patrizia $u Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy $u Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden $1 https://orcid.org/0000000307295246
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Nacmias, Benedetta $u Department of Neuroscience, Psychology, Drug Research and Child Health University of Florence, Florence, Italy $u IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy $1 https://orcid.org/0000000193389040
- 700 1_
- $a Spallazzi, Marco $u Department of Medicine and Surgery, Unit of Neurology, University-Hospital of Parma, Parma, Italy
- 700 1_
- $a Seripa, Davide $u Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Sánchez-Juan, Pascual $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $u Alzheimer's Centre Reina Sofia-CIEN Foundation-ISCIII, Madrid, Spain
- 700 1_
- $a Sleegers, Kristel $u Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium $u Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium $1 https://orcid.org/0000000202832332
- 700 1_
- $a Ingelsson, Martin $u Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden $u Krembil Brain Institute, University Health Network, Toronto, ON, Canada $u Tanz Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, ON, Canada
- 700 1_
- $a Haines, Jonathan $u Department of Population and Quantitative Health Sciences and Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA $1 https://orcid.org/0000000243514728 $7 uk2007404220
- 700 1_
- $a Farrer, Lindsay $u Department of Neurology, Boston University, Boston, MA, USA $u Department of Biostatistics, Boston University, Boston, MA, USA $u Department of Epidemiology, Boston University, Boston, MA, USA $u Department of Medicine (Biomedical Genetics), Boston University, Boston, MA, USA $u Department of Ophthalmology, Boston University, Boston, MA, USA $1 https://orcid.org/0000000155334225
- 700 1_
- $a Mayeux, Richard $u Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA $u Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA $1 https://orcid.org/0000000165199696
- 700 1_
- $a Wang, Li-San $u Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
- 700 1_
- $a Sims, Rebecca $u Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Wales, UK $1 https://orcid.org/0000000238851199
- 700 1_
- $a DeStefano, Anita $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA
- 700 1_
- $a Schellenberg, Gerard D $u Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
- 700 1_
- $a Seshadri, Sudha $u Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, San Antonio, TX, USA $u Boston University and the NHLBI's Framingham Heart Study, Boston, MA, USA $u Department of Neurology, Boston University School of Medicine, Boston, MA, USA $1 https://orcid.org/0000000161352622
- 700 1_
- $a Amouyel, Philippe $u Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France $1 https://orcid.org/000000019088234X
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Pericak-Vance, Margaret $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA $u Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA
- 700 1_
- $a Andreassen, Ole A $u NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway $u Institute of Clinical Medicine, University of Oslo, Oslo, Norway $1 https://orcid.org/0000000244613568
- 700 1_
- $a Van Duijn, Cornelia $u Nuffield Department of Population Health Oxford University, Oxford, UK $u Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands $1 https://orcid.org/0000000223749204
- 700 1_
- $a Hiltunen, Mikko $u Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
- 700 1_
- $a Ruiz, Agustín $u Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain $u CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain $1 https://orcid.org/0000000326332495
- 700 1_
- $a Dupuis, Josée $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA $u Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada $1 https://orcid.org/0000000328713603
- 700 1_
- $a Martin, Eden $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA $u Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA $u University of Miami Miller School of Medicine, Miami, FL, USA
- 700 1_
- $a Lambert, Jean-Charles $u Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France $1 https://orcid.org/0000000308297817
- 700 1_
- $a Kunkle, Brian $u The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA
- 700 1_
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- $a U24 AG072122 $p NIA NIH HHS $2 United States
- GRA __
- $a U01 AG032984 $p NIA NIH HHS $2 United States
- GRA __
- $a P30 AG066508 $p NIA NIH HHS $2 United States
- GRA __
- $a U24 AG041689 $p NIA NIH HHS $2 United States
- GRA __
- $a P30 AG072977 $p NIA NIH HHS $2 United States
- LZP __
- $a Pubmed-20250708
