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Horizontal mitochondrial transfer in cancer biology: Potential clinical relevance

MV. Berridge, R. Zobalova, S. Boukalova, A. Caicedo, SA. Rushworth, J. Neuzil

. 2025 ; 43 (5) : 803-807. [pub] 20250320

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25015756

Recent research highlights horizontal mitochondrial transfer as a key biological phenomenon linked to cancer onset and progression. The transfer of mitochondria and their genomes between cancer and non-cancer cells shifts our understanding of intercellular gene trafficking, increasing the metabolic fitness of cancer cells and modulating antitumor immune responses. This process not only facilitates tumor progression but also presents potential therapeutic opportunities.

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$a Boukalova, Stepana $u Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic
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$a Caicedo, Andrés $u Escuela de Medicina, Universidad San Francisco de Quito, Quito 170901, Ecuador; Mito-Act Research Consortium, Quito, Ecuador; Universidad San Francisco de Quito, Instituto de Investigaciones en Biomedicina iBiomed, Quito, Ecuador; Universidad San Francisco de Quito Space Front, Quito, Ecuador
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$a Rushworth, Stuart A $u Norwich Medical School, University of East Anglia, Norwich NR4 7UQ, UK
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$a Neuzil, Jiri $u Institute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic; School of Pharmacy and Medical Sciences, Griffith University, Southport, QLD 4222, Australia; Faculty of Science, Charles University, Prague 2 128 00, Czech Republic; First Faculty of Medicine, Charles University, Prague 2 128 00, Czech Republic. Electronic address: jiri.neuzil@ibt.cas.cz
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