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Recovery of mucosal-associated invariant T cells after myeloablative chemotherapy and autologous peripheral blood stem cell transplantation
J. Novak, J. Dobrovolny, J. Brozova, L. Novakova, T. Kozak,
Jazyk angličtina Země Itálie
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 2002-05-01 do 2018-12-31
Medline Complete (EBSCOhost)
od 2003-05-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2002-05-01 do 2018-12-31
- MeSH
- autologní transplantace metody MeSH
- C-reaktivní protein metabolismus MeSH
- cytarabin aplikace a dávkování farmakologie MeSH
- hematologické nádory krev imunologie terapie MeSH
- karmustin aplikace a dávkování farmakologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- MAIT buňky účinky léků metabolismus MeSH
- melfalan aplikace a dávkování farmakologie MeSH
- myeloablativní agonisté aplikace a dávkování farmakologie MeSH
- podofylotoxin aplikace a dávkování farmakologie MeSH
- příprava pacienta k transplantaci metody MeSH
- protokoly protinádorové kombinované chemoterapie aplikace a dávkování farmakologie MeSH
- transplantace periferních kmenových buněk metody MeSH
- věkové faktory MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Immune reconstitution after high-dose chemotherapy and stem cell transplantation plays a key role in restoring immunocompetence including defense against infection, immune regulation, and onco-immune surveillance. In this work, we examined the recovery of mucosal-associated invariant T (MAIT) cells, recently discovered innate-like T cells, after various types of myeloablative chemotherapy and autologous peripheral blood stem cell transplantation in 29 patients. We show that MAIT cells are relatively resistant to myeloablative conditioning. The median amount of MAIT cells rises to 43 % around day +30 and is sustained through further measurements on days +60 and +100. Moreover, MAIT cell recovery reaches 100 % of pre-treatment values in 33 % of patients already by day +60. The only factor affecting recovery of MAIT cells is age, younger age being associated with earlier MAIT cell recovery. The pre-treatment quantity of MAIT cells carries a prognostic impact on the early post-transplantation course. Patients with high levels of MAIT cells pre-treatment have significantly lower peak CRP levels (79.45 vs. 150 mg/L) post-treatment, reflecting a clinical trend of less severe infectious complications (less febrile days and less days on intravenous antibiotics). Altogether these data suggest that a high proportion of MAIT cells survive myeloablative chemotherapy and maintain their capacity to fight against infections probably on mucosal surfaces.
Citace poskytuje Crossref.org
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- $a Novak, Jan $u Department of Immunology, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. novakjan@centrum.cz. Department of Internal Medicine and Haematology, 3rd Faculty of Medicine, Charles University in Prague and Faculty Hospital Kralovske Vinohrady, Srobarova 50, 100 34, Prague 10, Czech Republic. novakjan@centrum.cz.
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- $a Immune reconstitution after high-dose chemotherapy and stem cell transplantation plays a key role in restoring immunocompetence including defense against infection, immune regulation, and onco-immune surveillance. In this work, we examined the recovery of mucosal-associated invariant T (MAIT) cells, recently discovered innate-like T cells, after various types of myeloablative chemotherapy and autologous peripheral blood stem cell transplantation in 29 patients. We show that MAIT cells are relatively resistant to myeloablative conditioning. The median amount of MAIT cells rises to 43 % around day +30 and is sustained through further measurements on days +60 and +100. Moreover, MAIT cell recovery reaches 100 % of pre-treatment values in 33 % of patients already by day +60. The only factor affecting recovery of MAIT cells is age, younger age being associated with earlier MAIT cell recovery. The pre-treatment quantity of MAIT cells carries a prognostic impact on the early post-transplantation course. Patients with high levels of MAIT cells pre-treatment have significantly lower peak CRP levels (79.45 vs. 150 mg/L) post-treatment, reflecting a clinical trend of less severe infectious complications (less febrile days and less days on intravenous antibiotics). Altogether these data suggest that a high proportion of MAIT cells survive myeloablative chemotherapy and maintain their capacity to fight against infections probably on mucosal surfaces.
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