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Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels
A. Filipova, M. Tomko, K. Ondacova, L. Dubiel-Hoppanova, N. Chmúrčiaková, L. Cmarko, RN. Stringer, N. Weiss, L. Lacinova
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
2/0081/22
VEGA
2/0081/22
VEGA
2/0081/22
VEGA
2/0081/22
VEGA
2/0081/22
VEGA
START/MED/054
Charles University
START/MED/054
Charles University
START/MED/054
Charles University
START/MED/054
Charles University
NLK
BioMedCentral
od 2008-12-01
BioMedCentral Open Access
od 2008
Directory of Open Access Journals
od 2008
Free Medical Journals
od 2008
PubMed Central
od 2008
Europe PubMed Central
od 2008
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2008-01-01
Open Access Digital Library
od 2008-01-01
Medline Complete (EBSCOhost)
od 2009-01-13
Health & Medicine (ProQuest)
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2008
Springer Nature OA/Free Journals
od 2008-12-01
- MeSH
- hipokampus * cytologie účinky léků MeSH
- homocystein * farmakologie MeSH
- iontové kanály * genetika metabolismus MeSH
- krysa rodu rattus MeSH
- kultivované buňky MeSH
- neurony * účinky léků metabolismus cytologie MeSH
- potkani Sprague-Dawley MeSH
- regulace genové exprese * účinky léků MeSH
- vápník metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of exposing cultured rat hippocampal neurons to Hcy concentrations corresponding to mild, moderate, and severe hyperhomocysteinemia. A short 24-hour exposure had minimal effects, whereas prolonged exposure up to 14 days moderately enhanced hippocampal excitability without altering the gene expression of voltage-dependent calcium, sodium, or potassium channels or intracellular calcium levels. These findings suggest that Hcy-induced changes in neuronal excitability may contribute to neuropathologies associated with hyperhomocysteinemia.
Citace poskytuje Crossref.org
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