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Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson's disease
J. Rusz, P. Dusek, T. Tykalova, M. Novotny, V. Illner, M. Simek, T. Kouba, P. Kryze, D. Zogala, E. Ruzicka, M. Sousa, A. Jorge, T. Nef, P. Krack
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 1944-07-01 do Před 6 měsíci
Nursing & Allied Health Database (ProQuest)
od 1944-07-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 1944-07-01 do Před 6 měsíci
Psychology Database (ProQuest)
od 1944-07-01 do Před 6 měsíci
PubMed
39288960
DOI
10.1136/jnnp-2024-334297
Knihovny.cz E-zdroje
- MeSH
- bazální ganglia * patofyziologie diagnostické zobrazování MeSH
- dysartrie patofyziologie diagnostické zobrazování etiologie MeSH
- funkční lateralita * fyziologie MeSH
- jednofotonová emisní výpočetní tomografie MeSH
- lidé středního věku MeSH
- lidé MeSH
- Parkinsonova nemoc * patofyziologie diagnostické zobrazování komplikace MeSH
- proteiny přenášející dopamin přes plazmatickou membránu metabolismus MeSH
- putamen diagnostické zobrazování metabolismus patofyziologie MeSH
- řeč * fyziologie MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere. METHODS: Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT). RESULTS: From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01). CONCLUSION: Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.
ARTORG Center for Biomedical Engineering Research University of Bern Bern Switzerland
Movement Disorders Center Department of Neurology University Hospital of Bern Bern Switzerland
Citace poskytuje Crossref.org
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- $a Rusz, Jan $u Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic rusz.mz@gmail.com $u Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic $1 https://orcid.org/0000000210363054 $7 xx0093732
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