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The microelectrode array technique - a crucial tool for studying excitable tissue disorders and drug testing: an update on recent advances
A. Angelovski, M. Bébarová
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
- MeSH
- elektrofyziologické jevy MeSH
- lidé MeSH
- mikroelektrody * MeSH
- preklinické hodnocení léčiv metody přístrojové vybavení MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The microelectrode array (MEA) is an electronic device composed of a varying number of microelectrodes used to detect the extracellular field potential generated by excitable tissues. This technology allows for the measurement of electrical activity without damaging the cell membrane during recording. MEA offers a better way of getting long-term recordings and observing different cellular activities than the invasive patch clamp technique. Recent research demonstrates that MEA technology enables scientists to detect both cellular and subcellular events, allowing them to study cellular properties and reactions across different experimental conditions and even to identify distinct ion currents and their impact on cellular electrophysiology. The paper reviews the historical development of MEA technology along with its modern applications for electrophysiological research. The future advancement of MEA technology will improve our knowledge about neuronal and cardiac excitability and expand its use to additional electrically active tissues, advancing research in pharmacology, neuroscience, cardiology, and other fields.
Citace poskytuje Crossref.org
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- $a Angelovski, Andrijana $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; First Department of Neurology, Faculty of Medicine and St. Anne's University Hospital, Masaryk University, Brno, Czech Republic
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- $a The microelectrode array (MEA) is an electronic device composed of a varying number of microelectrodes used to detect the extracellular field potential generated by excitable tissues. This technology allows for the measurement of electrical activity without damaging the cell membrane during recording. MEA offers a better way of getting long-term recordings and observing different cellular activities than the invasive patch clamp technique. Recent research demonstrates that MEA technology enables scientists to detect both cellular and subcellular events, allowing them to study cellular properties and reactions across different experimental conditions and even to identify distinct ion currents and their impact on cellular electrophysiology. The paper reviews the historical development of MEA technology along with its modern applications for electrophysiological research. The future advancement of MEA technology will improve our knowledge about neuronal and cardiac excitability and expand its use to additional electrically active tissues, advancing research in pharmacology, neuroscience, cardiology, and other fields.
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- $a Bébarová, Markéta $u Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; First Department of Neurology, Faculty of Medicine and St. Anne's University Hospital, Masaryk University, Brno, Czech Republic. Electronic address: mbebar@med.muni.cz
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