Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Relationship between gliadin peptide structure and their effect on the fetal chick duodenum

P. Kocna, T. Mothes, V. Krchnak

. 1991 ; Roč. 192 (č. 2) : S. 116-119.

Jazyk angličtina Země Německo

Perzistentní odkaz   https://www.medvik.cz/link/bmc92004940

Grantová podpora
IZ707 MZ0 CEP - Centrální evidence projektů

The tendency to form a beta-turn in alpha-gliadin was estimated using the B-cell determinant prediction program based on the Chou and Fasman probability of beta-turn formation. Six sequences possessing a high probability of beta-turn formation were found. A statistically high agreement was found between these six sequences and three areas in alpha-gliadin with the occurrence of Pro-Ser-Gln-Gln sequence which has recently been considered responsible for toxicity in coeliac disease. By means of solid-phase synthesis seven peptides were obtained covering the above-mentioned regions. Their toxicity was tested using the fetal chick duodenum. The results support the suggestion that peptides containing the sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro may be involved in the pathogenesis of coeliac disease.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc92004940
003      
CZ-PrNML
005      
20140113113734.0
008      
920500s1991 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1007/bf01202623 $2 doi
035    __
$a (PubMed)2014713
040    __
$a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Kocna, Petr, $d 1955- $4 aut $7 jo2003181502 $u Laboratory of Gastroenterology, Faculty of General Medicine, Charles University, Prague, Czechoslovakia.
245    10
$a Relationship between gliadin peptide structure and their effect on the fetal chick duodenum / $c P. Kocna, T. Mothes, V. Krchnak
314    __
$a Charles University. Faculty of General Medicine. Laboratory of Gastroenterology Prague, CZ
520    9_
$a The tendency to form a beta-turn in alpha-gliadin was estimated using the B-cell determinant prediction program based on the Chou and Fasman probability of beta-turn formation. Six sequences possessing a high probability of beta-turn formation were found. A statistically high agreement was found between these six sequences and three areas in alpha-gliadin with the occurrence of Pro-Ser-Gln-Gln sequence which has recently been considered responsible for toxicity in coeliac disease. By means of solid-phase synthesis seven peptides were obtained covering the above-mentioned regions. Their toxicity was tested using the fetal chick duodenum. The results support the suggestion that peptides containing the sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro may be involved in the pathogenesis of coeliac disease.
590    __
$a bohemika - dle Pubmed
650    02
$a celiakie $x etiologie $7 D002446
650    02
$a duodenum $x embryologie $x účinky léků $7 D004386
650    12
$a gliadin $x chemie $x toxicita $7 D005903
650    02
$a molekulární sekvence - údaje $7 D008969
650    12
$a zvířata $7 D000818
650    02
$a kuřecí embryo $7 D002642
700    1_
$a Mothes, T. $4 aut
700    1_
$a Krchňák, V. $4 aut
700    1_
$a Fric, P. $4 aut
773    0_
$w MED00004800 $t Zeitschrift für Lebensmittel-Untersuchung und -Forschung $g Roč. 192, č. 2 (1991), S. 116-119 $x 0044-3026 $p Z Lebensm Unters Forsch
773    0_
$p Z Lebensm Unters Forsch $g 192(2):116-9, 1991 Feb $x 0044-3026
910    __
$a ABA008 $b x $y 4 $z 0
990    __
$a 20060427 $b ABA008
991    __
$a 20140113114437 $b ABA008
999    __
$a ok $b bmc $g 347397 $s 193337
BAS    __
$a 3
BMC    __
$a 1991 $b Roč. 192 $c č. 2 $d S. 116-119 $i 0044-3026 $m Zeitschrift für Lebensmittel-Untersuchung und -Forschung $x MED00004800
GRA    __
$a IZ707 $p MZ0
LZP    __
$a 2011-B
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace