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Relationship between gliadin peptide structure and their effect on the fetal chick duodenum

P. Kocna, T. Mothes, V. Krchnak

. 1991 ; Roč. 192 (č. 2) : S. 116-119.

Jazyk angličtina Země Německo

Perzistentní odkaz   https://www.medvik.cz/link/bmc92004940

Grantová podpora
IZ707 MZ0 CEP - Centrální evidence projektů

The tendency to form a beta-turn in alpha-gliadin was estimated using the B-cell determinant prediction program based on the Chou and Fasman probability of beta-turn formation. Six sequences possessing a high probability of beta-turn formation were found. A statistically high agreement was found between these six sequences and three areas in alpha-gliadin with the occurrence of Pro-Ser-Gln-Gln sequence which has recently been considered responsible for toxicity in coeliac disease. By means of solid-phase synthesis seven peptides were obtained covering the above-mentioned regions. Their toxicity was tested using the fetal chick duodenum. The results support the suggestion that peptides containing the sequences Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro may be involved in the pathogenesis of coeliac disease.

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