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Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity
J. Vagner, P. Kocna, V. Krchnak
Language English Country United States
Grant support
IZ707
MZ0
CEP Register
PubMed
1839365
Knihovny.cz E-resources
- MeSH
- Duodenum enzymology drug effects MeSH
- Gliadin pharmacology chemically induced chemistry MeSH
- Chick Embryo MeSH
- Oncogene Proteins, Viral chemistry MeSH
- Peptide Fragments pharmacology chemically induced chemistry MeSH
- In Vitro Techniques MeSH
- Ultrasonics MeSH
- Animals MeSH
- Check Tag
- Chick Embryo MeSH
- Animals MeSH
Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.
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- 009
- AR
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- $a Continuous-flow synthesis of alpha-gliadin peptides in an ultrasonic field and assay of their inhibition of intestinal sucrase activity / $c J. Vagner, P. Kocna, V. Krchnak
- 314 __
- $a Research Institute for Feed Supplements and Veterinary Drugs Prague, CZ
- 520 9_
- $a Three dodecapeptide amides derived from the amino acid sequence of alpha-gliadin and four of their analogues were synthesized by continuous-flow solid-phase multiple peptide synthesis. Ultrasonic field conditions accelerated the coupling reaction without affecting purity. Biological tests of the synthetic fragments showed the relevance of toxicity prediction for preselection of immunogenic alpha-gliadin fragments.
- 650 _2
- $a peptidové fragmenty $x farmakologie $x chemicky indukované $x chemie $7 D010446
- 650 _2
- $a gliadin $x farmakologie $x chemicky indukované $x chemie $7 D005903
- 650 _2
- $a onkogenní proteiny virové $x chemie $7 D009856
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- $a duodenum $x enzymologie $x účinky léků $7 D004386
- 650 _2
- $a aminokyseliny - pořadí
- 650 _2
- $a ultrazvuk $7 D014465
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a kuřecí embryo $7 D002642
- 650 _2
- $a techniky in vitro $7 D066298
- 700 1_
- $a Kocna, Petr, $d 1955- $4 aut $7 jo2003181502
- 700 1_
- $a Krchňák, V. $4 aut
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- $w MED00182796 $t Pept.Res.(USA) $g Roč. 4, č. 5 (1991), S. 284-288 $x 1040-5704
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- $a 3
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- GRA __
- $a IZ707 $p MZ0
