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Liposomy a jejich osud v kůži
[Liposomes and their fate in the skin]
Libuše Mardešičová, J. Schramlová, K. Blažek
Jazyk čeština Země Česko
Digitální knihovna NLK
Zdroj
- MeSH
- fagocytóza MeSH
- farmakokinetika MeSH
- fyziologie kůže MeSH
- králíci MeSH
- kůže anatomie a histologie MeSH
- léčivé přípravky aplikace a dávkování MeSH
- liposomy farmakokinetika terapeutické užití MeSH
- morčata MeSH
- velikost částic MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- morčata MeSH
- zvířata MeSH
To test liposome penetration through the skin the authors used liposomes with encapsulated protein G with gold conjugate in a gel vehicle. Skin specimens were taken 2, 4, 24,48 and 72 hours after application and were examined histologically and by electron microscopy. The findings indicate that the passage through the skin depends above all on liposome size. Liposomes with a diameter of 600 nm penetrate easily through the skin while liposomes with a diameter above 1000 nm remain in the stratum corneum. The main penetration of liposomes takes place along hair follicles as indicated by a larger amount of free liposomes in the corium of furred guinea pigs.
Liposomes and their fate in the skin
Liposomy a jejich osud v kůži = Liposomes and their fate in the skin /
Liposomes and their fate in the skin /
Lit: 21
Bibliografie atd.Souhrn en
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- $a To test liposome penetration through the skin the authors used liposomes with encapsulated protein G with gold conjugate in a gel vehicle. Skin specimens were taken 2, 4, 24,48 and 72 hours after application and were examined histologically and by electron microscopy. The findings indicate that the passage through the skin depends above all on liposome size. Liposomes with a diameter of 600 nm penetrate easily through the skin while liposomes with a diameter above 1000 nm remain in the stratum corneum. The main penetration of liposomes takes place along hair follicles as indicated by a larger amount of free liposomes in the corium of furred guinea pigs.
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