Disappearance of haemopoietic stem cells from blood after hydroxyurea
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
305368
Knihovny.cz E-zdroje
- MeSH
- faktory stimulující kolonie krev MeSH
- hematopoetické kmenové buňky účinky léků MeSH
- hydroxymočovina aplikace a dávkování farmakologie MeSH
- injekce intraperitoneální MeSH
- myši MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- faktory stimulující kolonie MeSH
- hydroxymočovina MeSH
Haemopoietic stem cells were examined in the blood of mice which had been injected with hydroxyurea. It was observed that the amount of CFU in the blood quickly decreased and after higher doses of hydroxyurea CFU completely disappeared from blood. Since CFU are rather resistant to the killing effect of hydroxyurea, it is assumed that the observed effect is caused either by an interference of hydroxyurea (due to its effect on the blood-forming tissues) with the migration of CFU into blood or by stimulating the removal og CFU from blood.