The aim of our study was to reveal whether acute methamphetamine (MA) administration changes the sensitivity to seizures induced by N-methyl-D-aspartate (NMDA) in prenatally MA-exposed adult rats. Adult rats with respect to sex and female estrous cycle (prenatally MA-exposed, prenatally saline-exposed, and controls) were divided into groups with acute MA (1 mg/kg) or without acute drug administration (saline injection). Intraperitoneal administration of 250 mg/kg of NMDA was used as a seizure model. The present study demonstrated that both prenatal MA and prenatal saline exposure decreased the latency to onset of stereotypy and clonic-tonic seizures. Acute MA administration decreased latency to onset of stereotypic behavior in all groups, while increased latency to onset of clonic-tonic seizures in prenatally saline-exposed rats. The duration of NMDA seizures was longer after acute MA administration relative to animals without acute MA pretreatment in both control groups. In addition, males displayed decreased susceptibility to NMDA-induced seizures relative to females regardless of their estrous cycle. Our study suggests that acute MA exposure changes susceptibility to NMDA-induced seizures in respect of prenatal exposure and sex. However, it seems that the effect of prenatal exposure is not induced by the drug per se but rather by the repeated injection exposure that causes prenatal stress.

Department of Normal Pathological and Clinical Physiology 3rd Faculty of Medicine Charles University Prague Praha 2 Prague Czech Republic

Zobrazit více v PubMed

Synapse. 2006 Dec 1;60(7):521-32 PubMed

Brain Res Dev Brain Res. 2000 May 11;121(1):119-22 PubMed

Epilepsy Res. 2005 Jun;65(1-2):121-4 PubMed

Pharmacol Biochem Behav. 1995 Oct;52(2):291-6 PubMed

Pharmacol Biochem Behav. 2004 Mar;77(3):509-15 PubMed

Brain Res. 1999 Aug 14;838(1-2):136-50 PubMed

Pharmacol Biochem Behav. 2000 Nov;67(3):501-5 PubMed

Neuropsychopharmacology. 2006 May;31(5):941-55 PubMed

Epilepsia. 2005 Jun;46(6):956-60 PubMed

Pharmacol Biochem Behav. 2000 Jan 1;65(1):39-42 PubMed

Neuroscience. 2003;122(3):579-83 PubMed

Dev Psychobiol. 1999 Apr;34(3):227-34 PubMed

Seizure. 2001 Jul;10(5):319-40 PubMed

Physiol Behav. 1991 Jun;49(6):1181-3 PubMed

Am Fam Physician. 2002 Oct 15;66(8):1489-94 PubMed

Epilepsia. 1998;39 Suppl 8:S2-8 PubMed

Eur Neuropsychopharmacol. 1999 Mar;9(3):239-45 PubMed

Neuroscience. 2007 Dec 5;150(2):433-41 PubMed

Neurotoxicol Teratol. 1996 Mar-Apr;18(2):199-215 PubMed

Hum Psychopharmacol. 2001 Jan;16(S1):S7-S19 PubMed

Pharmacol Biochem Behav. 1994 Jul;48(3):587-91 PubMed

Epilepsia. 1999 Oct;40(10):1357-69 PubMed

Brain Res. 2005 Oct 26;1060(1-2):193-7 PubMed

Eur J Pharmacol. 2002 Jan 25;435(2-3):181-5 PubMed

Neurology. 1994 Nov;44(11 Suppl 8):S14-23 PubMed

Brain Res Bull. 1997;43(5):447-55 PubMed

Epilepsia. 1998 Dec;39(12):1243-52 PubMed

Epilepsia. 2002;43 Suppl 2:28-31 PubMed

Naunyn Schmiedebergs Arch Pharmacol. 2001 Apr;363(4):422-8 PubMed

NIDA Res Monogr. 1993;133:185-205 PubMed

Int J Neurosci. 2001;108(3-4):175-91 PubMed

Dev Psychobiol. 2005 Jan;46(1):57-65 PubMed

Ann N Y Acad Sci. 2006 Aug;1074:198-224 PubMed

Eur J Pharmacol. 2004 Sep 13;498(1-3):157-61 PubMed

Horm Behav. 2002 Dec;42(4):437-47 PubMed

Naunyn Schmiedebergs Arch Pharmacol. 2005 Nov;372(3):236-41 PubMed

Synapse. 1996 Mar;22(3):217-25 PubMed

Brain Res. 1997 Mar 28;752(1-2):279-84 PubMed

Epilepsia. 2000;41 Suppl 6:S30-5 PubMed

Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):97-105 PubMed

An overview of the methamphetamine effect on male sexual behavior and reproductive system

Does paternal methamphetamine exposure affect the behavior of rat offspring during development and in adulthood?