Effects of a single postnatal methamphetamine administration on NMDA-induced seizures are sex- and prenatal exposure-specific
Language English Country Germany Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Excitatory Amino Acid Agonists administration & dosage toxicity MeSH
- Time Factors MeSH
- Estrous Cycle physiology MeSH
- Rats MeSH
- Methamphetamine pharmacology MeSH
- N-Methylaspartate administration & dosage toxicity MeSH
- Rats, Wistar MeSH
- Drug Administration Schedule MeSH
- Sex Factors MeSH
- Stereotyped Behavior drug effects MeSH
- Central Nervous System Stimulants pharmacology MeSH
- Pregnancy MeSH
- Seizures chemically induced MeSH
- Prenatal Exposure Delayed Effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Excitatory Amino Acid Agonists MeSH
- Methamphetamine MeSH
- N-Methylaspartate MeSH
- Central Nervous System Stimulants MeSH
The aim of our study was to reveal whether acute methamphetamine (MA) administration changes the sensitivity to seizures induced by N-methyl-D-aspartate (NMDA) in prenatally MA-exposed adult rats. Adult rats with respect to sex and female estrous cycle (prenatally MA-exposed, prenatally saline-exposed, and controls) were divided into groups with acute MA (1 mg/kg) or without acute drug administration (saline injection). Intraperitoneal administration of 250 mg/kg of NMDA was used as a seizure model. The present study demonstrated that both prenatal MA and prenatal saline exposure decreased the latency to onset of stereotypy and clonic-tonic seizures. Acute MA administration decreased latency to onset of stereotypic behavior in all groups, while increased latency to onset of clonic-tonic seizures in prenatally saline-exposed rats. The duration of NMDA seizures was longer after acute MA administration relative to animals without acute MA pretreatment in both control groups. In addition, males displayed decreased susceptibility to NMDA-induced seizures relative to females regardless of their estrous cycle. Our study suggests that acute MA exposure changes susceptibility to NMDA-induced seizures in respect of prenatal exposure and sex. However, it seems that the effect of prenatal exposure is not induced by the drug per se but rather by the repeated injection exposure that causes prenatal stress.
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Pharmacol Biochem Behav. 1995 Oct;52(2):291-6 PubMed
Pharmacol Biochem Behav. 2004 Mar;77(3):509-15 PubMed
Brain Res. 1999 Aug 14;838(1-2):136-50 PubMed
Pharmacol Biochem Behav. 2000 Nov;67(3):501-5 PubMed
Neuropsychopharmacology. 2006 May;31(5):941-55 PubMed
Epilepsia. 2005 Jun;46(6):956-60 PubMed
Pharmacol Biochem Behav. 2000 Jan 1;65(1):39-42 PubMed
Neuroscience. 2003;122(3):579-83 PubMed
Dev Psychobiol. 1999 Apr;34(3):227-34 PubMed
Seizure. 2001 Jul;10(5):319-40 PubMed
Physiol Behav. 1991 Jun;49(6):1181-3 PubMed
Am Fam Physician. 2002 Oct 15;66(8):1489-94 PubMed
Epilepsia. 1998;39 Suppl 8:S2-8 PubMed
Eur Neuropsychopharmacol. 1999 Mar;9(3):239-45 PubMed
Neuroscience. 2007 Dec 5;150(2):433-41 PubMed
Neurotoxicol Teratol. 1996 Mar-Apr;18(2):199-215 PubMed
Hum Psychopharmacol. 2001 Jan;16(S1):S7-S19 PubMed
Pharmacol Biochem Behav. 1994 Jul;48(3):587-91 PubMed
Epilepsia. 1999 Oct;40(10):1357-69 PubMed
Brain Res. 2005 Oct 26;1060(1-2):193-7 PubMed
Eur J Pharmacol. 2002 Jan 25;435(2-3):181-5 PubMed
Neurology. 1994 Nov;44(11 Suppl 8):S14-23 PubMed
Brain Res Bull. 1997;43(5):447-55 PubMed
Epilepsia. 1998 Dec;39(12):1243-52 PubMed
Epilepsia. 2002;43 Suppl 2:28-31 PubMed
Naunyn Schmiedebergs Arch Pharmacol. 2001 Apr;363(4):422-8 PubMed
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Int J Neurosci. 2001;108(3-4):175-91 PubMed
Dev Psychobiol. 2005 Jan;46(1):57-65 PubMed
Ann N Y Acad Sci. 2006 Aug;1074:198-224 PubMed
Eur J Pharmacol. 2004 Sep 13;498(1-3):157-61 PubMed
Horm Behav. 2002 Dec;42(4):437-47 PubMed
Naunyn Schmiedebergs Arch Pharmacol. 2005 Nov;372(3):236-41 PubMed
Synapse. 1996 Mar;22(3):217-25 PubMed
Brain Res. 1997 Mar 28;752(1-2):279-84 PubMed
Epilepsia. 2000;41 Suppl 6:S30-5 PubMed
Brain Res Dev Brain Res. 2003 Dec 30;147(1-2):97-105 PubMed
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