Growth, glucose metabolism and melanin formation in biotin-deficient Aspergillus nidulans
Language English Country United States Media print
Document type Journal Article
PubMed
402307
DOI
10.1007/bf02876995
Knihovny.cz E-resources
- MeSH
- Fructose-Bisphosphate Aldolase metabolism MeSH
- Aspergillus nidulans enzymology growth & development metabolism MeSH
- Biotin biosynthesis MeSH
- Dihydroxyphenylalanine metabolism MeSH
- Glucosephosphate Dehydrogenase metabolism MeSH
- Glucose metabolism MeSH
- Glutamate Dehydrogenase metabolism MeSH
- Hexokinase metabolism MeSH
- Melanins biosynthesis MeSH
- Mutation MeSH
- NADH, NADPH Oxidoreductases metabolism MeSH
- Oxygen Consumption MeSH
- Monophenol Monooxygenase metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Fructose-Bisphosphate Aldolase MeSH
- Biotin MeSH
- Dihydroxyphenylalanine MeSH
- Glucosephosphate Dehydrogenase MeSH
- Glucose MeSH
- Glutamate Dehydrogenase MeSH
- Hexokinase MeSH
- Melanins MeSH
- NADH, NADPH Oxidoreductases MeSH
- Monophenol Monooxygenase MeSH
Biotin deficiency resulted in an increased growth rate of Aspergillus nidulans. The activities of hexokinase and aldolase were not much changed during the growth cycle, but activities of glucose-6-phosphate dehydrogenase and NADP-linked glutamate dehydrogenase increased significantly during the exponential phase. This change was remarkable during biotin deficiency. In contrast to the higher growth rate and respiration rate during biotin deficiency the activities of NAD(P)H oxidoreductases were low. An inverse relationship between the activity of tyrosinase and melanin content was observed. A role of the DOPA-DOPA-quinone system in maintaining culture growth is suggested.
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