Growth, glucose metabolism and melanin formation in biotin-deficient Aspergillus nidulans
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
402307
DOI
10.1007/bf02876995
Knihovny.cz E-zdroje
- MeSH
- aldolasa metabolismus MeSH
- Aspergillus nidulans enzymologie růst a vývoj metabolismus MeSH
- biotin biosyntéza MeSH
- dihydroxyfenylalanin metabolismus MeSH
- glukosa-6-fosfátdehydrogenasa metabolismus MeSH
- glukosa metabolismus MeSH
- glutamátdehydrogenasa metabolismus MeSH
- hexokinasa metabolismus MeSH
- melaniny biosyntéza MeSH
- mutace MeSH
- NADH, NADPH oxidoreduktasy metabolismus MeSH
- spotřeba kyslíku MeSH
- tyrosinasa metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- aldolasa MeSH
- biotin MeSH
- dihydroxyfenylalanin MeSH
- glukosa-6-fosfátdehydrogenasa MeSH
- glukosa MeSH
- glutamátdehydrogenasa MeSH
- hexokinasa MeSH
- melaniny MeSH
- NADH, NADPH oxidoreduktasy MeSH
- tyrosinasa MeSH
Biotin deficiency resulted in an increased growth rate of Aspergillus nidulans. The activities of hexokinase and aldolase were not much changed during the growth cycle, but activities of glucose-6-phosphate dehydrogenase and NADP-linked glutamate dehydrogenase increased significantly during the exponential phase. This change was remarkable during biotin deficiency. In contrast to the higher growth rate and respiration rate during biotin deficiency the activities of NAD(P)H oxidoreductases were low. An inverse relationship between the activity of tyrosinase and melanin content was observed. A role of the DOPA-DOPA-quinone system in maintaining culture growth is suggested.
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