The effect of ten derivatives of carbonylcyanide phenylhydrazone on growth of bacteria, yeast and different species of filamentous fungi was investigated. In yeast and mitochondria isolated from rat liver the effect of these derivatives on the respiratory activity was also followed. The relative efficiency of the individual derivatives of carbonylcyanide phenylhydrazone was determined on the basis of the results obtained. It was shown that derivatives, in which the substituent on the benzene ring causes simultaneously an increase of acidity and lipophilicity of the derivative as compared with the non-substituted carbonylcyanide phenylhydrazone (4-trifluoromethoxy-, 3-chloro-, 4-chloro and 3,4-dichloro-derivatives) were most effective.

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J Membr Biol. 1975-1976;25(3-4):361-80 PubMed

Folia Microbiol (Praha). 1974;19(5):367-72 PubMed

J Supramol Struct. 1975;3(3):201-13 PubMed

Biochem Biophys Res Commun. 1962 May 4;7:272-5 PubMed

Biochem J. 1965 Dec;97(3):658-62 PubMed

Biochem J. 1967 Aug;104(2):588-600 PubMed

Biochemistry. 1963 Mar-Apr;2:357-61 PubMed

Biochem J. 1958 Jun;69(2):306-11 PubMed

Proc Natl Acad Sci U S A. 1976 Sep;73(9):3141-5 PubMed

J Biol Chem. 1956 Nov;223(1):147-56 PubMed

Proc Natl Acad Sci U S A. 1974 Feb;71(2):288-92 PubMed

Biochem Soc Trans. 1976;4(3):399-430 PubMed

J Biol Chem. 1975 Jan 25;250(2):396-408 PubMed

Biochim Biophys Acta. 1962 Sep 10;63:46-54 PubMed

J Biol Chem. 1956 Aug;221(2):609-18 PubMed

Biochem Pharmacol. 1964 Mar;13:285-318 PubMed

Proc Natl Acad Sci U S A. 1968 Feb;59(2):484-90 PubMed

Folia Microbiol (Praha). 1967;12(1):56-63 PubMed

Biochim Biophys Acta. 1975 Aug 11;396(2):165-74 PubMed

Biochem Biophys Res Commun. 1967 Oct 26;29(2):153-7 PubMed

J Biol Chem. 1948 Apr;173(2):807 PubMed

Anal Biochem. 1961 Aug;2:335-43 PubMed

Biochemistry. 1963 Sep-Oct;2:1142-7 PubMed

Bacteriol Rev. 1972 Jun;36(2):172-230 PubMed

Biochim Biophys Acta. 1976 Sep 27;456(2):129-48 PubMed

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