The cytoplasmic membrane as a site of the primary effect of colicins on eukaryotic cells
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
456693
Knihovny.cz E-zdroje
- MeSH
- aktivace lymfocytů účinky léků MeSH
- antigeny povrchové analýza MeSH
- buněčná membrána imunologie MeSH
- fibroblasty účinky léků MeSH
- histokompatibilita - antigeny analýza MeSH
- koliciny farmakologie MeSH
- konkanavalin A farmakologie MeSH
- lymfocyty účinky léků imunologie metabolismus MeSH
- myši inbrední C57BL MeSH
- myši MeSH
- receptory konkanavalinu A analýza MeSH
- thymidin metabolismus MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antigeny povrchové MeSH
- histokompatibilita - antigeny MeSH
- koliciny MeSH
- konkanavalin A MeSH
- receptory konkanavalinu A MeSH
- thymidin MeSH
The effect of colicins E3 and K on mouse lymphoid cells was studied. Low doses of colicin E3, which were not toxic, inhibited profoundly the Con A-induced activation of lymphocytes while the Con A binding capacity of the treated cells was retained. The inhibitory effect of colicin E3 was also found when the homing of 51Cr-labelled lymph node cells to the lymph nodes of syngeneic recipients was studied, while the rate of redistribution of H-2 antigens on the surface of the lymphocytes was not changed by colicin E3 or colicin K. The findings suggest that the cytoplasmic membrane is the site of the primary effect of colicin E3 on eukaryotic cells.
Colicins--exocellular lethal proteins of Escherichia coli
Cytotoxic effects of colicins E1-E5 and K on hamster fibroblasts
