The cytoplasmic membrane as a site of the primary effect of colicins on eukaryotic cells
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
456693
Knihovny.cz E-resources
- MeSH
- Lymphocyte Activation drug effects MeSH
- Antigens, Surface analysis MeSH
- Cell Membrane immunology MeSH
- Fibroblasts drug effects MeSH
- Histocompatibility Antigens analysis MeSH
- Colicins pharmacology MeSH
- Concanavalin A pharmacology MeSH
- Lymphocytes drug effects immunology metabolism MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Receptors, Concanavalin A analysis MeSH
- Thymidine metabolism MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Antigens, Surface MeSH
- Histocompatibility Antigens MeSH
- Colicins MeSH
- Concanavalin A MeSH
- Receptors, Concanavalin A MeSH
- Thymidine MeSH
The effect of colicins E3 and K on mouse lymphoid cells was studied. Low doses of colicin E3, which were not toxic, inhibited profoundly the Con A-induced activation of lymphocytes while the Con A binding capacity of the treated cells was retained. The inhibitory effect of colicin E3 was also found when the homing of 51Cr-labelled lymph node cells to the lymph nodes of syngeneic recipients was studied, while the rate of redistribution of H-2 antigens on the surface of the lymphocytes was not changed by colicin E3 or colicin K. The findings suggest that the cytoplasmic membrane is the site of the primary effect of colicin E3 on eukaryotic cells.
Colicins--exocellular lethal proteins of Escherichia coli
Cytotoxic effects of colicins E1-E5 and K on hamster fibroblasts
