The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD.

] Broad Institute of MIT and Harvard Cambridge Massachusetts USA [2] Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge Massachusetts USA

] Broad Institute of MIT and Harvard Cambridge Massachusetts USA [2] Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology Cambridge Massachusetts USA [3] Department of Biology Massachusetts Institute of Technology Cambridge Massachusetts USA

] Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle Washington USA [2] Cardiology Division University of Washington Seattle Washington USA

] Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle Washington USA [2] Department of Epidemiology University of Washington Seattle Washington USA

] Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle Washington USA [2] Department of Epidemiology University of Washington Seattle Washington USA [3] Department of Health Services University of Washington Seattle Washington USA [4] Group Health Research Institute Group Health Cooperative Seattle Washington USA [5] Department of Medicine University of Washington Seattle Washington USA

] Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle Washington USA [2] Department of Epidemiology University of Washington Seattle Washington USA [3] Department of Medicine University of Washington Seattle Washington USA

] Center for Biomedicine European Academy Bozen Bolzano [2] Department of Neurology University of Lübeck Lübeck Germany [3] Department of Neurology General Central Hospital Bolzano Italy

] Center for Biomedicine European Academy Bozen Bolzano [2] Institute of Human Genetics Technische Universität München Munich Germany [3] Institute for Bioinformatics and Systems Biology Helmholtz Zentrum Munich Germany [4]

] Center for Complex Disease Genomics McKusick Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA [2]

] Center for Human Genetic Research Massachusetts General Hospital Boston Massachusetts USA [2] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [3] Cardiovascular Research Center Massachusetts General Hospital Boston Massachusetts USA

] Center for Human Genetic Research Massachusetts General Hospital Boston Massachusetts USA [2] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [3] Cardiovascular Research Center Massachusetts General Hospital Boston Massachusetts USA [4] Department of Cardiology Lund University Lund Sweden

] Center for Human Genetic Research Massachusetts General Hospital Boston Massachusetts USA [2] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [3] Department of Medical Genetics Center for Molecular Medicine University Medical Center Utrecht Utrecht The Netherlands [4]

] Center for Human Genetic Research Massachusetts General Hospital Boston Massachusetts USA [2] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [3] Harvard Medical School Boston Massachusetts USA [4] Cardiovascular Research Center Massachusetts General Hospital Boston Massachusetts USA [5]

] Christine Kühne Center for Allergy and Education Munich Germany [2] Department of Dermatology and Allergy Technische Universität München Munich Germany

] Clinical Pharmacology William Harvey Research Institute Barts and the London School of Medicine Queen Mary University of London London UK [2] Barts and the London Genome Centre William Harvey Research Institute Barts and the London School of Medicine Queen Mary University of London London UK

] Computational and Systems Biology Program Division of Biology and Biomedical Sciences Washington University in St Louis St Louis Missouri USA [2] Department of Medicine Division of Oncology Washington University School of Medicine St Louis Missouri USA

] Cyprus Cardiovascular and Educational Research Trust Nicosia Cyprus [2] Vascular Screening and Diagnostic Centre London UK

] Cyprus International Institute for Environmental and Public Health in association with the Harvard School of Public Health Cyprus University of Technology Limassol Cyprus [2] Cyprus Cardiovascular and Educational Research Trust Nicosia Cyprus

] deCODE genetics Reykjavik Iceland [2] Faculty of Medicine University of Iceland Reykjavik Iceland

] Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville Tennessee USA [2] Department of Medicine Vanderbilt University School of Medicine Nashville Tennessee USA

] Department of Biostatistics Institute of Basic Medical Sciences University of Oslo Oslo Norway [2] Department of Public Health and Community Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden

] Department of Cardiology University of Groningen University Medical Center Groningen Groningen The Netherlands [2] Department of Genetics University of Groningen University Medical Center Groningen Groningen The Netherlands

] Department of Clinical Physiology and Nuclear Medicine Turku University Hospital Turku Finland [2] Research Centre of Applied and Preventive Cardiovascular Medicine University of Turku Turku Finland

] Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands [2] Netherlands Consortium for Healthy Aging Leiden The Netherlands

] Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands [2] Netherlands Consortium for Healthy Aging Leiden The Netherlands [3] Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands

] Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands [2] Netherlands Consortium for Healthy Aging Leiden The Netherlands [3] Department of Medical Informatics Erasmus Medical Center Rotterdam The Netherlands [4] Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands [5] Inspectorate of Health Care The Hague The Netherlands

] Department of Genomics Life and Brain Center University of Bonn Bonn Germany [2] Institute of Human Genetics University of Bonn Bonn Germany

] Department of Genomics Life and Brain Center University of Bonn Bonn Germany [2] Institute of Human Genetics University of Bonn Bonn Germany [3] Division of Medical Genetics University Hospital Basel Basel Switzerland [4] Department of Biomedicine University of Basel Basel Switzerland

] Department of Genomics Life and Brain Center University of Bonn Bonn Germany [2] Institute of Human Genetics University of Bonn Bonn Germany [3] Institute of Neuroscience and Medicine Structural and Functional Organization of the Brain Genomic Imaging Research Centre Juelich Juelich Germany

] Department of Internal Medicine B University Medicine Greifswald Greifswald Germany [2] DZHK partner site Greifswald Greifswald Germany

] Department of Medical and Clinical Genetics Sahlgrenska Academy at the University of Gothenburg Gothenburg Sweden [2] Biobanking and Molecular Resource Infrastructure of Sweden Gothenburg Sweden

] Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden [2] Department of Medical Sciences Molecular Epidemiology and Science for Life Laboratory Uppsala University Uppsala Sweden

] Department of Medical Genetics Center for Molecular Medicine University Medical Center Utrecht Utrecht The Netherlands [2] Department of Epidemiology Julius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht The Netherlands [3]

] Department of Medical Sciences Molecular Epidemiology and Science for Life Laboratory Uppsala University Uppsala Sweden [2] MRC Epidemiology Unit University of Cambridge Institute of Metabolic Science Addenbrooke's Hospital Cambridge UK

] Department of Medical Sciences Molecular Epidemiology and Science for Life Laboratory Uppsala University Uppsala Sweden [2] School of Health and Social Sciences Dalarna University Falun Sweden

] Department of Medical Sciences Molecular Epidemiology and Science for Life Laboratory Uppsala University Uppsala Sweden [2] Wellcome Trust Centre for Human Genetics University of Oxford Oxford UK

] Department of Medicine 1 University Hospital Munich Ludwig Maximilians Universität Munich Germany [2] Department of Medicine Hospital of Friedberg Friedberg Germany

] Department of Medicine 1 University Hospital Munich Ludwig Maximilians Universität Munich Germany [2] DZHK partner site Munich Heart Alliance Munich Germany

] Department of Medicine 1 University Hospital Munich Ludwig Maximilians Universität Munich Germany [2] Institute of Medical Informatics Biometry and Epidemiology Chair of Epidemiology Ludwig Maximilians Universität Munich Germany [3] Institute of Genetic Epidemiology Helmholtz Zentrum Munich German Research Center for Environmental Health Neuherberg Germany [4] Institute of Medical Informatics Biometry and Epidemiology Chair of Genetic Epidemiology Ludwig Maximilians Universität Munich Germany [5] DZHK partner site Munich Heart Alliance Munich Germany

] Department of Medicine Division of Genetics Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA [2] Harvard Bioinformatics and Integrative Genomics Boston Massachusetts USA

] Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA [2] Program for Personalized and Genomic Medicine University of Maryland Baltimore Maryland USA

] Department of Medicine University of Maryland School of Medicine Baltimore Maryland USA [2] Program for Personalized and Genomic Medicine University of Maryland Baltimore Maryland USA [3] Geriatric Research and Education Clinical Center Veterans Administration Medical Center Baltimore Maryland USA

] Department of Medicine Vanderbilt University School of Medicine Nashville Tennessee USA [2] Department of Pharmacology Vanderbilt University Nashville Tennessee USA [3] Office of Personalized Medicine Vanderbilt University Nashville Tennessee USA

] Department of Molecular Medicine Section of Cardiology University of Pavia Pavia Italy [2] Center for Cardiac Arrhythmias of Genetic Origin Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano Milan Italy

] Department of Molecular Medicine Section of Cardiology University of Pavia Pavia Italy [2] Center for Cardiac Arrhythmias of Genetic Origin Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano Milan Italy [3] Institute of Human Genetics Helmholtz Zentrum München Neuherberg Germany

] Department of Pediatrics Division of Pediatric Cardiology Mayo Clinic Rochester Minnesota USA [2] Windland Smith Rice Sudden Death Genomics Laboratory Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester Minnesota USA

] Department of Pediatrics Division of Pediatric Cardiology Mayo Clinic Rochester Minnesota USA [2] Windland Smith Rice Sudden Death Genomics Laboratory Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester Minnesota USA [3] Department of Medicine Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota USA [4]

] Department of Public Health and Community Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden [2] Global Epidemiology AstraZeneca Research and Development Mölndal Sweden

] Division of Cardiology Johns Hopkins University School of Medicine Baltimore Maryland USA [2] Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA

] Durrer Center for Cardiogenetic Research Interuniversity Cardiology Institute of The Netherlands Netherlands Heart Institute Utrecht The Netherlands [2] Department of Cardiology Division of Heart and Lungs University Medical Centre Utrecht Utrecht The Netherlands [3] Institute of Cardiovascular Science Faculty of Population Health Sciences University College London London UK

] DZHK partner site Greifswald Greifswald Germany [2] Interfaculty Institute for Genetics and Functional Genomics Ernst Moritz Arndt University Greifswald Greifswald Germany

] DZHK partner site Munich Heart Alliance Munich Germany [2] Institute of Epidemiology 2 Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany

] DZHK partner site Munich Heart Alliance Munich Germany [2] Institute of Human Genetics Technische Universität München Munich Germany [3] Research Unit of Molecular Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany

] Grupo de Medicina Xenómica Centro Nacional de Genotipado Centro de Investigación Biomédica en Red de Enfermedades Raras Universidade de Santiago de Compostela Santiago de Compostela Spain [2] Fundación Publica Galega de Medicina Xenómica Servicio Galego de Saude Santiago de Compostela Spain [3] Center of Excellence in Genomic Medicine Research King Abdulaziz University Jeddah Saudi Arabia

] Grupo de Medicina Xenómica Centro Nacional de Genotipado Centro de Investigación Biomédica en Red de Enfermedades Raras Universidade de Santiago de Compostela Santiago de Compostela Spain [2] Xenética de Enfermidades Cardiovasculares e Oftalmolóxicas Complexo Hospitalario Universitario de Santiago de Compostela Servicio Galego de Saude Santiago de Compostela Spain

] Heart Failure Research Center Department of Clinical and Experimental Cardiology Academic Medical Center Amsterdam The Netherlands [2] Princess Al Jawhara Al Brahim Centre of Excellence in Research of Hereditary Disorders Jeddah Saudi Arabia

] Icelandic Heart Association Kopavogur Iceland [2] Faculty of Medicine University of Iceland Reykjavik Iceland

] Institut du Thorax Centre Hospitalier Universitaire de Nantes Université de Nantes Nantes France [2] Institut du Thorax INSERM UMR1087 CNRS UMR 6291 Université de Nantes Nantes France

] Institute for Maternal and Child Health Burlo Garofolo Trieste Trieste Italy [2] Clinical Department of Medical Surgical and Health Sciences University of Trieste Trieste Italy

] Institute of Medical Epidemiology Biostatistics and Informatics Martin Luther University Halle Wittenberg Halle Germany [2] Division of Cancer Epidemiology German Cancer Research Centre Heidelberg Germany

] Laboratory of Cardiovascular Sciences Human Cardiovascular Studies Unit National Institute on Aging US National Institutes of Health Baltimore Maryland USA [2] Translational Gerontology Branch National Institute on Aging Baltimore Maryland USA

] MRC Epidemiology Unit University of Cambridge Institute of Metabolic Science Addenbrooke's Hospital Cambridge UK [2] Mindich Child Health and Development Institute Icahn School of Medicine at Mount Sinai New York New York USA [3] Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York New York USA

] National Heart Lung and Blood Institute Framingham Heart Study Framingham Massachusetts USA [2] Cardiology Division Massachusetts General Hospital Boston Massachusetts USA

] National Heart Lung and Blood Institute Framingham Heart Study Framingham Massachusetts USA [2] Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA

] National Heart Lung and Blood Institute Framingham Heart Study Framingham Massachusetts USA [2] Department of Biostatistics Boston University School of Public Health Boston Massachusetts USA [3] Department of Mathematics and Statistics Boston University Boston Massachusetts USA

] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [2] Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts USA

] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [2] Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts USA [3] Harvard Medical School Boston Massachusetts USA

] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [2] Analytic and Translational Genetics Unit Massachusetts General Hospital Boston Massachusetts USA [3] Novo Nordisk Foundation Center for Protein Research Faculty of Health Sciences University of Copenhagen Copenhagen Denmark [4] Center for Biological Sequence Analysis Department of Systems Biology Technical University of Denmark Lyngby Denmark [5] Pediatric Surgical Research Laboratories MassGeneral Hospital for Children Massachusetts General Hospital Boston Massachusetts USA

] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [2] Department of Medicine Division of Genetics Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA [3] Partners HealthCare Center for Personalized Genetic Medicine Boston Massachusetts USA [4] Division of Rheumatology Immunology and Allergy Brigham and Women's Hospital Boston Massachusetts USA [5] Faculty of Medical and Human Sciences University of Manchester Manchester UK

] Program in Medical and Population Genetics Broad Institute of Harvard and MIT Cambridge Massachusetts USA [2] Novo Nordisk Foundation Center for Protein Research Faculty of Health Sciences University of Copenhagen Copenhagen Denmark [3] The Danish National Research Foundation Centre for Cardiac Arrhythmia University of Copenhagen Copenhagen Denmark

] Public Health Genomics Unit National Institute for Health and Welfare Helsinki Finland [2] Institute for Molecular Medicine Finland University of Helsinki Helsinki Finland [3] Estonian Genome Center University of Tartu Tartu Estonia

] Research Programs Unit Molecular Medicine University of Helsinki Helsinki Finland [2] Department of Medicine Helsinki University Central Hospital Helsinki Finland

] The Labatt Family Heart Centre The Hospital for Sick Children Toronto Ontario Canada [2] Department of Pediatrics The Hospital for Sick Children Toronto Ontario Canada

1st Department of Internal Medicine Paracelsus Medical University Salzburger Landeskliniken Salzburg Austria

2nd Department of Internal Medicine Paracelsus Medical University Salzburger Landeskliniken Salzburg Austria

BHF Glasgow Cardiovascular Research Centre Institute of Cardiovascular and Medical Sciences College of Medical Veterinary and Life Sciences University of Glasgow Glasgow UK

Biobank PopGen Institute of Experimental Medicine Christian Albrechts University of Kiel Kiel Germany

Biomedical Sciences St George's University of London London UK

California Pacific Medical Center Research Institute San Francisco California USA

Cardiovascular and Cell Sciences Institute St George's University of London London UK

Cardiovascular Department Ospedali Riuniti and University of Trieste Trieste Italy

Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle Washington USA

Center for Biomedicine European Academy Bozen Bolzano

Center for Cardiac Arrhythmias of Genetic Origin Istituto di Ricerca e Cura a Carattere Scientifico Istituto Auxologico Italiano Milan Italy

Center for Complex Disease Genomics McKusick Nathans Institute of Genetic Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA

Center for Human Genetics Research Vanderbilt University School of Medicine Nashville Tennessee USA

Center for Statistical Genetics Department of Biostatistics University of Michigan Ann Arbor Michigan USA

Center for Systems Genomics Pennsylvania State University University Park Pennsylvania USA

Centre for Experimental Medicine Institute for Clinical and Experimental Medicine Prague Czech Republic

Centre for Population Health Sciences University of Edinburgh Edinburgh UK

Chronic Disease Epidemiology and Prevention Unit National Institute for Health and Welfare Helsinki Finland

Clinical Pharmacology University of Cambridge Addenbrooke's Hospital Cambridge UK

Clinical Pharmacology William Harvey Research Institute Barts and the London School of Medicine Queen Mary University of London London UK

Department of Biology Massachusetts Institute of Technology Cambridge Massachusetts USA

Department of Biomedical Engineering Johns Hopkins University Baltimore Maryland USA

Department of Cardiology University Hospital of Essen University Duisburg Essen Essen Germany

Department of Cardiology University of Groningen University Medical Center Groningen Groningen The Netherlands

Department of Cardiovascular Science University of Leicester Glenfield Hospital Leicester UK

Department of Clinical Chemistry Fimlab Laboratories and University of Tampere School of Medicine Tampere Finland

Department of Clinical Genetics Academic Medical Center Amsterdam The Netherlands

Department of Clinical Physiology Tampere University Hospital and University of Tampere School of Medicine Tampere Finland

Department of Epidemiology and Prevention Division of Public Health Sciences Wake Forest University Winston Salem North Carolina USA

Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands

Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health Baltimore Maryland USA

Department of Epidemiology University of Groningen University Medical Center Groningen Groningen The Netherlands

Department of Genetics University of Groningen University Medical Center Groningen Groningen The Netherlands

Department of Internal Medicine 3 University Medical Center Schleswig Holstein Campus Kiel Kiel Germany

Department of Internal Medicine University of Groningen University Medical Center Groningen Groningen The Netherlands

Department of Medical Informatics Erasmus Medical Center Rotterdam The Netherlands

Department of Medical Sciences Molecular Epidemiology and Science for Life Laboratory Uppsala University Uppsala Sweden

Department of Medical Sciences Uppsala University Uppsala Sweden

Department of Medicine 1 University Hospital Munich Ludwig Maximilians Universität Munich Germany

Department of Medicine 3 Medical Faculty Martin Luther University Halle Wittenberg Halle Germany

Department of Medicine Division of Cardiology Helsinki University Central Hospital Helsinki Finland

Department of Medicine Division of Cardiology Landspitali University Hospital Reykjavik Iceland

Department of Medicine Turku University Hospital and University of Turku Turku Finland

Department of Medicine University of Helsinki Helsinki Finland

Department of Neurology Innsbruck Medical University Innsbruck Austria

Department of Pharmacology Ernst Moritz Arndt University of Greifswald Greifswald Germany

Department of Primary Care and Population Health University College London Royal Free Campus London UK

Department of Public Health Faculty of Medicine University of Split Split Croatia

Department of Twin Research and Genetic Epidemiology King's College London London UK

Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis Minnesota USA

Division of Genetic Epidemiology Innsbruck Medical University Innsbruck Austria

Division of Population Health Sciences and Education St George's University of London London UK

eCODE genetics Reykjavik Iceland

Electrocardiology University of Glasgow Institute of Cardiovascular and Medical Sciences Royal Infirmary Glasgow UK

General Practice and Primary Care University of Glasgow Glasgow UK

Genetic Epidemiology Unit Department of Epidemiology Erasmus University Medical Center Rotterdam The Netherlands

Genetics and Genome Biology Program The Hospital for Sick Children Research Institute Toronto Ontario Canada

Grupo de Medicina Xenómica Centro Nacional de Genotipado Centro de Investigación Biomédica en Red de Enfermedades Raras Universidade de Santiago de Compostela Santiago de Compostela Spain

Heart Failure Research Center Department of Clinical and Experimental Cardiology Academic Medical Center Amsterdam The Netherlands

Human Genetics Research Centre St George's University of London London UK

Icelandic Heart Association Kopavogur Iceland

Informatics and Biocomputing Platform Ontario Institute for Cancer Research Toronto Ontario Canada

Institut du Thorax INSERM UMR1087 CNRS UMR 6291 Université de Nantes Nantes France

Institute for Biological and Medical Imaging Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany

Institute for Community Medicine University Medicine Greifswald Greifswald Germany

Institute for Maternal and Child Health Burlo Garofolo Trieste Trieste Italy

Institute for Medical Informatics Biometry and Epidemiology University Hospital of Essen University Duisburg Essen Essen Germany

Institute for Translational Genomics and Population Sciences Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center Torrance California USA

Institute of Cardiovascular Science University College London London UK

Institute of Clinical Molecular Biology Christian Albrechts University of Kiel Kiel Germany

Institute of Genetic Epidemiology Helmholtz Zentrum Munich German Research Center for Environmental Health Neuherberg Germany

Institute of Medical Epidemiology Biostatistics and Informatics Martin Luther University Halle Wittenberg Halle Germany

Istituto di Ricerca Genetica e Biomedica Consiglio Nazionale delle Ricerche Monserrato Cagliari Italy

Laboratory of Cardiovascular Sciences Human Cardiovascular Studies Unit National Institute on Aging US National Institutes of Health Baltimore Maryland USA

Laboratory of Epidemiology Demography and Biometry National Institute on Aging Bethesda Maryland USA

Laboratory of Genetics Intramural Research Program National Institute on Aging US National Institutes of Health Baltimore Maryland USA

Laboratory of Neurogenetics National Institute on Aging US National Institutes of Health Bethesda Maryland USA

Medical Genetics Unit Casa Sollievo della Sofferenza San Giovanni Rotondo Italy

Medical Research Council Human Genetics Unit Institute of Genetics and Molecular Medicine Western General Hospital Edinburgh UK

National Heart Lung and Blood Institute Framingham Heart Study Framingham Massachusetts USA

Novo Nordisk Foundation Center for Protein Research Faculty of Health Sciences University of Copenhagen Copenhagen Denmark

Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

Research Unit of Molecular Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany

Sanofi Research and Development Paris France

The Centre for Applied Genomics The Hospital for Sick Children Toronto Ontario Canada

Translational Gerontology Branch National Institute on Aging Baltimore Maryland USA

Vascular Screening and Diagnostic Centre London UK

Windland Smith Rice Sudden Death Genomics Laboratory Department of Molecular Pharmacology and Experimental Therapeutics Mayo Clinic Rochester Minnesota USA

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