High-level resistance to cycloheximide resulting from an interaction of the mutated pdr3 and cyh genes in yeast
Language English Country United States Media print
Document type Journal Article
PubMed
1394518
DOI
10.1007/bf00317932
Knihovny.cz E-resources
- MeSH
- Drug Resistance, Microbial genetics MeSH
- Cycloheximide pharmacology MeSH
- Gene Expression * MeSH
- Genes, Fungal * MeSH
- Mutation MeSH
- Saccharomyces cerevisiae drug effects genetics MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cycloheximide MeSH
In addition to pdr3-1, the S. cerevisiae nuclear pleiotropic drug resistance mutant 2D was found to contain another recessive nuclear mutation, cyh, conferring specific resistance to cycloheximide only. The cycloheximide resistance level due to either the pdr3-1 or the cyh mutation alone was low and was not altered by the ogd1 mutation which increased the physiological acidification of the culture. When pdr3-1 and cyh mutations occurred simultaneously in the haploid yeast strain their interaction was synergistic and resulted in high-level resistance to cycloheximide.
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