High-level resistance to cycloheximide resulting from an interaction of the mutated pdr3 and cyh genes in yeast
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
1394518
DOI
10.1007/bf00317932
Knihovny.cz E-zdroje
- MeSH
- antibiotická rezistence genetika MeSH
- cykloheximid farmakologie MeSH
- exprese genu * MeSH
- geny hub * MeSH
- mutace MeSH
- Saccharomyces cerevisiae účinky léků genetika MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- cykloheximid MeSH
In addition to pdr3-1, the S. cerevisiae nuclear pleiotropic drug resistance mutant 2D was found to contain another recessive nuclear mutation, cyh, conferring specific resistance to cycloheximide only. The cycloheximide resistance level due to either the pdr3-1 or the cyh mutation alone was low and was not altered by the ogd1 mutation which increased the physiological acidification of the culture. When pdr3-1 and cyh mutations occurred simultaneously in the haploid yeast strain their interaction was synergistic and resulted in high-level resistance to cycloheximide.
Zobrazit více v PubMed
Can J Genet Cytol. 1982;24(5):493-503 PubMed
Curr Genet. 1990 Jan;17(1):85-8 PubMed
Mol Cell Biol. 1988 Feb;8(2):664-73 PubMed
Biochem Biophys Res Commun. 1974 Mar 15;57(1):17-22 PubMed
Curr Genet. 1986;10(9):665-70 PubMed
J Biol Chem. 1987 Dec 15;262(35):16871-9 PubMed
Mol Gen Genet. 1987 Apr;207(1):38-46 PubMed
Eur J Biochem. 1977 Feb 15;73(1):275-86 PubMed
EMBO J. 1989 Dec 20;8(13):3973-84 PubMed
Biochim Biophys Acta. 1981 Dec;650(2-3):88-127 PubMed
Annu Rev Biochem. 1989;58:137-71 PubMed
Biochim Biophys Acta. 1991 Mar 4;1073(2):241-52 PubMed
Biochim Biophys Acta. 1991 Dec 12;1071(4):375-91 PubMed
