Carboplatin and cisplatin ototoxicity in guinea pigs
Language English Country Switzerland Media print
Document type Journal Article
PubMed
1449432
Knihovny.cz E-resources
- MeSH
- Acoustic Stimulation MeSH
- Cisplatin administration & dosage adverse effects pharmacology MeSH
- Drug Combinations MeSH
- Electrodes, Implanted MeSH
- Injections, Intraperitoneal MeSH
- Carboplatin administration & dosage adverse effects pharmacology MeSH
- Cochlea drug effects MeSH
- Mannitol MeSH
- Guinea Pigs MeSH
- Hearing * MeSH
- Auditory Threshold MeSH
- Hair Cells, Auditory drug effects MeSH
- Ear, Inner drug effects MeSH
- Animals MeSH
- Check Tag
- Guinea Pigs MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Cisplatin MeSH
- Drug Combinations MeSH
- Carboplatin MeSH
- Mannitol MeSH
Ototoxic effects of cisplatin (1.5 mg/kg), cisplatin with mannitol (1.5 mg/kg cisplatin with 15 mg/kg mannitol) and carboplatin (6 mg/kg) were compared in guinea pigs treated 5 days a week for 5 consecutive weeks. Auditory thresholds were measured in awake animals by means of the compound action potential recorded from electrodes implanted near the round window. The endocochlear potential (EP) was measured in the first turn through the round window, and hair cell counts were estimated by the surface specimen technique. The most pronounced ototoxicity (threshold shifts and hair cell loss) was observed with pure cisplatin. Cisplatin with mannitol appeared to be less toxic than pure cisplatin, and carboplatin the least toxic. Even carboplatin produced significant threshold shifts, particularly at high frequencies, but they were not accompanied by hair cell loss. Values of EP were not different from those in normal control animals.