The possibilities of changing the production of exocellular polysaccharides of a mutant Mycobacterium strain
Language English Country United States Media print
Document type Journal Article
PubMed
1452093
DOI
10.1007/bf02814556
Knihovny.cz E-resources
- MeSH
- Drug Resistance, Microbial genetics MeSH
- Polysaccharides, Bacterial biosynthesis drug effects MeSH
- Culture Media MeSH
- Methylnitronitrosoguanidine pharmacology MeSH
- Mutation MeSH
- Mycobacterium genetics metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Polysaccharides, Bacterial MeSH
- Culture Media MeSH
- Methylnitronitrosoguanidine MeSH
By second-step mutagenesis and treatment with N-methyl-N'-nitro-N-nitrosoguanidine a mutant strain of Mycobacterium sp. V-649 producing a glucan extracellular polymer and another new streptomycin-resistant mutant were prepared. This mutant strain formed more than 100% first-rate (1.0-1.2%) exocellular polysaccharide. Treatment with 1% dimethyl sulfoxide during submerged cultivation of the mutant strain did not increase the production of the extracellular polysaccharide.
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