Virulence of silver-resistant mutant of Klebsiella pneumoniae in burn wound model
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
1452094
DOI
10.1007/bf02814557
Knihovny.cz E-zdroje
- MeSH
- antibiotická rezistence genetika MeSH
- biologické modely MeSH
- dusičnan stříbrný farmakologie MeSH
- Klebsiella pneumoniae účinky léků genetika patogenita MeSH
- mutace MeSH
- myši MeSH
- popálení mikrobiologie MeSH
- virulence MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dusičnan stříbrný MeSH
A silver-resistant mutant of Klebsiella pneumoniae B-5 was produced by passaging in nutrient broth containing graded concentrations of silver nitrate up to 150 ppm. The development of silver resistance in the strain resulted in rough colonies, decrease in cell size, carbohydrate content and change in klebocin pattern. The virulence of the AgR strain as checked by the burn wound model decreased as the mutant could not establish itself in the skin and spleen of the animals and the organism was cleared more efficiently by human lymphocytes than the parent AgS strain.
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