Virulence of silver-resistant mutant of Klebsiella pneumoniae in burn wound model
Language English Country United States Media print
Document type Journal Article
PubMed
1452094
DOI
10.1007/bf02814557
Knihovny.cz E-resources
- MeSH
- Drug Resistance, Microbial genetics MeSH
- Models, Biological MeSH
- Silver Nitrate pharmacology MeSH
- Klebsiella pneumoniae drug effects genetics pathogenicity MeSH
- Mutation MeSH
- Mice MeSH
- Burns microbiology MeSH
- Virulence MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Silver Nitrate MeSH
A silver-resistant mutant of Klebsiella pneumoniae B-5 was produced by passaging in nutrient broth containing graded concentrations of silver nitrate up to 150 ppm. The development of silver resistance in the strain resulted in rough colonies, decrease in cell size, carbohydrate content and change in klebocin pattern. The virulence of the AgR strain as checked by the burn wound model decreased as the mutant could not establish itself in the skin and spleen of the animals and the organism was cleared more efficiently by human lymphocytes than the parent AgS strain.
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