Histamine liberation as a result of nonreceptor interaction
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu časopisecké články
PubMed
1695466
DOI
10.1007/bf01969002
Knihovny.cz E-zdroje
- MeSH
- beta blokátory farmakologie MeSH
- buněčná membrána účinky léků metabolismus MeSH
- inbrední kmeny potkanů MeSH
- krysa rodu Rattus MeSH
- mastocyty metabolismus ultrastruktura MeSH
- propanolaminy farmakologie MeSH
- receptory histaminu účinky léků fyziologie MeSH
- techniky in vitro MeSH
- uvolňování histaminu účinky léků MeSH
- vápník metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- beta blokátory MeSH
- exaprolol MeSH Prohlížeč
- propanolaminy MeSH
- receptory histaminu MeSH
- vápník MeSH
The highly lipophilic drug exaprolol liberates histamine from isolated mast cells and decreases the uptake of extracellular histamine in a dose-dependent manner. Intracellular histamine depletion was confirmed by electron microscopy and was accompanied by calcium displacement from intracellular storage sites. The significant decrease in membrane fluidity due to exaprolol was temperature-dependent and was most probably a result of its high membrane affinity and intracellular penetration. Membrane perturbation by exaprolol may account for this nonreceptor interaction. This could contribute to the understanding of adverse reactions to beta-adrenoceptor blocking drugs.
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